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Molecular Cardiology Research Institute
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About Us

Established in 1997, the Molecular Cardiology Research Institute at Tufts Medical Center is comprised of seventeen gifted investigators and physician-scientists teamed with over eighty highly-trained staff and engaged trainees.  The MCRI has as its mission the study of molecular mechanisms of human cardiovascular disease; translation of bench findings to new bedside strategies for diagnosis and therapy; and the mentoring of MD and PhD trainees committed to a career in academic cardiovascular research.   These scientists are located on six contiguous floors of research space on the Tufts Medical Center and Tufts University School of Medicine campus in downtown Boston.  

  • Since its inception the Institute has invested especially in three principal areas: recruitment of scientists and physician-scientists of the highest quality, establishment and growth of specific programs in cardiovascular research, and establishment of state-of-the-art Core facilities.
  • The MCRI programmatic areas of focus include vascular biology, cardiomyocyte biology, electrophysiology, human genetics and genomics, molecular pharmacology, and signal transduction. Members of the MCRI work closely and collaboratively with clinical cardiologists and cardiovascular surgeons, biochemists, neuroscientists, pharmacologists, geneticists and epidemiologists at Tufts Medical Center and Tufts University to further research in all facets of cardiovascular diseases.  Research in MCRI laboratories is focused on:
    • How the heart pump and electrical system function at the most basic levels;
    • How the cells, arteries and muscles of blood vessels work to control blood pressure; 
    •  How various cardiovascular diseases like heart attacks and angina actually get their start and how they evolve. 
  • Pre-doctoral, graduate, and post-graduate training are high priorities of the Institute, with numerous trainees, including students from the Sackler School of Graduate Biomedical Sciences at Tufts and post-doctoral fellows from all over the world conducting their research in MCRI labs annually. 
  • The MCRI is the home of an NIH-funded Training Program in Cardiovascular Research, which offers nine training positions annually to promising new investigators. 
  • In addition, the Institute sponsors a Molecular Medicine Seminar Series  throughout the academic year and an annual Retreat with nationally and internationally recognized guest speakers participating.