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Molecular Cardiology Research Institute
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1998 – 2002 Publications

Karas RH, Gauer EA, Bieber HE, Baur WE, Mendelsohn ME.  Growth factor activation of the estrogen receptor in vascular cells occurs via a mitogen-activated protein kinase-independent pathway.  Journal of Clinical Investigation 1998;101(12):2851-2861. PubMed Abstract


Beinborn M, Quinn SM, Kopin AS.  Minor modifications of a cholecystokinin-B/gastrin receptor non-peptide antagonist confer a broad spectrum of functional properties.  Journal of Biological Chemistry 1998;273(23):14146-14151. PubMed Abstract


Lindner V, Kim SK, Karas RH, Kuiper GJM, Gustafsson J, Mendelsohn ME.  Increased expression of estrogen-receptor-β mRNA in male blood vessels after vascular injury.  Circulation Research 1998;83:224-229. PubMed Abstract


Schaffer K, McBride EW, Beinborn M, Kopin AS.  Interspecies polymorphisms confer consitutive activity to the Mastomys cholecystokinin-B/gastrin receptor.  Journal of Biological Chemistry 1998;273(44):28779-28784. PubMed Abstract


Berul CI, Christe ME, Aronovitz MJ, Maguire CT, Seidman CE, Seidman JG, Mendelsohn ME.  Familial hypertrophic cardiomyopathy mice display gender differences in electrophysiological abnormalities.  Journal Interv Cardiovasc Electrophys 1998;2:7-14. PubMed Abstract


Bläker M, Ren Y, Gordon MC, Hsu JE, Beinborn M, Kopin AS.  Mutations within the cholecystokinin-B/gastrin receptor ligand ‘pocket’ interconvert the functions of nonpeptide agonists and antagonists.  Molecular Pharmacology 1998;54:857-863. PubMed Abstract


Wang G-R, Zhu Y, Halushka P, Lincoln T, Mendelsohn ME.  Mechanism of platelet inhibition by nitric oxide: In vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase.  Proceedings of the National Academy of Sciences, 1998;USA 95:4888-4893. PubMed Abstract


Karas RH, Mendelsohn ME.  Rapid vasomotor effects of estrogen: Men are part of the club.  Chest (Editorial) 1998;114(6):1508-1509. PubMed Abstract


Estes NAM, Mendelsohn ME.  Molecular biology of human arrhythmias: Implications for the clinical electrophysiologist.  Journal Interv Cardiovasc Electrophys 1998;2(4):321-324. PubMed Abstract


Patten RD, Aronovitz MJ, Deras-Mejia L, Pandian N, Hanak GG, Smith JJ, Mendelsohn ME, Konstam MA.  Ventricular remodeling in a mouse model of myocardial infarction.  American Journal Physiol 1998;274:H1812-H1820. PubMed Abstract


Thomas SA, Schuessler RB, Berul CI, Beardslee MA, Beyer EC, Mendelsohn ME, Saffitz JE.  Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: Evidence for chamber-specific molecular determinants of conduction.  Circulation 1998;97(7):686-691. PubMed Abstract


Rindi G, Langhans N, Rehfeld JF, Beinborn M, Kopin AS.  Abnormal gastric morphology and function in CCK-B/gastrin receptor-deficient mice.  Yale Journal of Biology and Medicine 1998;71:347-354. PubMed Abstract


Beinborn M, Chen C, DeMeo L, McBride EW, Kopin AS.  Small synthetic ligands of the cholecystokinin-B/gastrin receptor can mimic the function of endogenous peptide hormones.  Yale Journal of Biology and Medicine 1998;71:337-346. PubMed Abstract


Taylor K, Patten RD, Smith JJ, Aronovitz M, Wight J, Salomon RN, Konstam MA.  Divergent effects of angiotensin converting enzyme inhibition and angiotensin II – receptor Anatagonism on myocardial cellular proliferation and collagen deposition after myocardial infarction in rats.  Journal of Cardiovascular Pharmacology 1998;31(5):654-660. PubMed Abstract


Kilgallen CM, Jackson E, Bankoff M, Salomon RN, Surks HK.  A case of giant cell myocarditis and malignant thymoma: A postmortem diagnosis by needle biopsy.  Clinical Cardiology 1998;21(1):48-51. PubMed Abstract

 

Patten RD, Udelson JE, Konstam MA.  Ventricular remodeling and its prevention in the treatment of heart failure.  Current Opinion in Cardiology 1998;13:162-167.  PubMed Abstract


Kopin AS, Mathes WF, McBride EW, Nguyen M, Al-Haider W, Schmitz F, Bonner-Weir S, Kanarek R, Beinborn M.  The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight.  Journal of Clinical Investigation 1999;103(3):383-391. PubMed Abstract


Lem J, Krasnoperova NV, Calvert PD, Kosaras B, Cameron DA, Nicolo M, Makino CL, Sidman R.  Morphological, physiological and biochemical changes in rhodopsin knockout mice.  Proceedings of the National Academy of Sciences, USA 1999;96:736-741. PubMed Abstract


Pace MC, Chambliss KL, German Z, Yuhanna IS, Mendelsohn ME, Shaul PW.  Establishment of an immortablized fetal intrapulmonary artery endothelial cell line.  American Journal Physiol 1999;277(21):L106-L112. PubMed Abstract


Michael SK, Brennan J, Robertson EJ.  Efficient gene-specific expression of cre recombinase in the mouse embryo by targeted insertion of a novel IRES-Cre cassette into endogenous loci.  Mechanisms of Development 1999;85:35-47. PubMed Abstract


Frederick J, Krasnoperova N, Hoffmann K, Baehr W, Lem J, Klaus R.  Retinal degeneration is accelerated when a mutant rhodopsin transgene is expressed on a haploid or null rhodopsin background. In.  Retinal Degenerative Diseases and Experimental Therapy, 1999;Hollyfield JG (ed.), Plenum Publishers.Chapter 10:105-115.


Saba S, VanderBrink B, Luciano B, Aronovitz MJ, Berul CI, Reddy S, Housman D, Mendelsohn ME, Estes NA, Wang PJ.  Localization of the sites of conduction abnormalities in a mouse model of myotonic dystrophy.  Journal Clin Electrophys 1999;10(9):1214-1220. PubMed Abstract


Surks HK, Mochizuki N, Kasai Y, Georgescu S, Tang M, Ito M, Lincoln TM, Mendelsohn ME.  Regulation of myosin phosphatase by a specific interaction with cGMP-dependent protein kinase 1α.  Science 1999;286:1583-1587. PubMed Abstract


Karas RH, Hodgins JB, Kwoun M, Krege JH, Aronovitz M, Mackey W, Gustafsson JA, Korach KS, Smithies O, Mendelsohn ME.  Estrogen inhibits the vascular injury response in estrogen receptor β-deficient female mice.  Proceedings of the National Academy of Sciences, USA 1999;96(26):15133-15136. PubMed Abstract


VanderBrink BA, Link MS, Aronovitz MJ, Saba S, Sloan SB, Homoud MK, Estes III NAM, Wang PJ.  Assesment of antrioventricular nodal physiology in the mouse.  Journal Interv Cardiovasc Electrophys 1999;3(3):207-212. PubMed Abstract


Mendelsohn ME, Karas RH.  Mechanisms of Disease: The protective effects of estrogen on the cardiovascular system.  New England Journal of Medicine 1999;340(23):1801-1811. PubMed Abstract


Chen Z, Yuhanna IS, Galcheva-Gargova Z, Karas RH, Mendelsohn ME, Shaul PW.  Estrogen receptor α mediates nongenomic activation of endothelial nitric oxide synthase by estrogen.  Journal of Clinical Investigation 1999;103(3):401-406. PubMed Abstract


Berul CI, Maguire CT, Aronovitz MJ, Greenwood J, Miller C,Gehrmann J, Housman D, Mendelsohn ME, Reddy S.  DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy Model.  Journal of Clinical Investigation 1999;103(4):R1-R7. PubMed Abstract


Kuliopulos A, Covic L, Seeley SK, Sheridan PJ, Helin J, Costello CE.  Plasmin desensitization of the PAR1 thrombin receptor: Kinetics, sites of truncation and implications for thrombolytic therapy.  Biochemistry 1999;38(14):4572-4585. PubMed Abstract


Blomberg PJ, Surks HK, Long A, Rebeiz E, Mochizuki Y, Pandian N.  Transient myocardial dysfunction associated with angiotensin-converting enzyme inhibitor-induced angioedema: Recognition by serial echocardiographic studies.  Journal of the American Society of Echocardiography 1999;12(12):1107-1109. PubMed Abstract


Foran SE, Carr DB, Lipkowski AW, Maszczynska I, Marchand JE, Misicka A, Beinborn M, Kopin AS, Kream RM.  A substance P-opoid chimeric peptide as a unique nontolerance-forming analgesic.  Proceedings of the National Academy of Sciences, USA 2000;97(13):7621-7626. PubMed Abstract


Ji B, Kopin AS, Logsdon CD.  Species differences between rat and mouse CCK-A receptors determine the divergent acinar cell response to the cholecystokinin analog JMV-180.  Journal of Biological Chemistry 2000;275(25):19115-19120. PubMed Abstract


Covic L, Gresser AL, Kuliopulos A.  Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets.  Biochemistry 2000;39(18):5458-5467. PubMed Abstract


Santos BF, Serrano SMT, Kuliopulos A, Niewiarowski S.  Interaction of viper venom serine peptidases with thrombin receptors on human platelets.  Federation of European Biochemical Societies Letters 2000;477:199-202. PubMed Abstract


Cox DH, Aldrich RW.  Role of the β1 subunit in large-conductance Ca2+-activated K+ channel gating energetics: Mechanisms of enhanced Ca2+ sensitivity.  Journal of General Physiology 2000;116:411-432. PubMed Abstract


Jacques SL, LeMasurier M, Sheridan PJ, Seeley S, Kuliopulos A.  Substrate-assisted catalysis of the PAR1 thrombin receptor: Enhancement of macromolecular association and cleavage.  Journal of Biological Chemistry 2000;275(52):40671-40678. PubMed Abstract


Konstam MA, Patten RD, Thomas I, Ramahi T, La Bresh K, Goldman S, Lewis W, Gradman A, Self  KS, Bittner V, Rand W, Kinan D, Smith JJ, Ford T, Segal R, Udelson JE.  Effects of losartan and captopril on left ventricular volumes in elderly patients with heart failure:  Results of the ELITE ventricular function substudy.  American Heart Journal 2000;139(6):1081-1087. PubMed Abstract


Patten RD, Udelson JE, Konstam MA.  Left Ventricular dysfunction and heart failure following myocardial infarction: Early intervention in high-risk patients. In.  Heart Failure Management, 2000;Sharpe N. (ed.), Martin Dunitz, LTD, London.Chapter 14:183-198.


Foran SE, Carr DB, Lipkowski AW, Maszczynska I, Marchand JE, Misicka A, Beinborn M, Kopin AS, Kream RM.  Inhibition of morphine tolerance development by a substance P-opiod peptide chimera.  Journal of Pharmacology and Experimental Therapeutics 2000;295(3):1142-1148. PubMed Abstract


Mendelsohn ME.  Mechanisms of estrogen action in the cardiovascular system.  Journal of Steroid Biochemistry and Molecular Biology 2000;74(5):337-343. PubMed Abstract


Mendelsohn ME.  Nongenomic, estrogen receptor-mediated activation of endothelial nitric oxide synthase: How does it work? What does it mean? (SCOR) Circulation Research 2000;87:956-960. PubMed Abstract


Chambliss KL, Yuhanna IS, Mineo C, Liu P, German Z, Sherman TS, Mendelsohn ME, Anderson RGW, Shaul PW.  Estrogen receptor α and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae. (SCOR) Circulation Research 2000;87:e44-e52. PubMed Abstract


Mendez A, Burns M, Roca A, Lem J, Wu LW, Simon MI, Baylor DA, Chen J.  Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites.  Neuron 2000;28:153-164. PubMed Abstract


Calvert PD, Krasnoperova NV, Lyubarsky AL, Isayama T, Nicolo M, Kosaras B, Wong G, Gannon KS, Margolskee RF, Sidman RL, Pugh EN Jr, Makino CL, Lem J.  Phototransduction in transgenic mice after targeted deletion of the rod transducin α-subunit.  Proceedings of the National Academy of Sciences, USA 2000;97(25):13913-13918. PubMed Abstract


Nagy L, Morales RE, Beinborn M, Vattay P, Szabo S.  Investigation of gastroprotective compounds at subcellular level in isolated gastric mucosal cells.  American Journal Physiol Gastrointes Liver Physiol 2000;279:G1201-G1208. PubMed Abstract


Swift S, Sheridan PJ, Covic L, Kuliopulos A.  PAR1 thrombin receptor-G protein interactions: Separation of binding and coupling determinants in the Gα subunit.  Journal of Biological Chemistry 2000;275(4):2627-2635. PubMed Abstract


Poelzel G, Kasai Y, Mochizuki N, Shaul PW, Brown M, Mendelsohn ME.  Specific association of estrogen receptor β with a cell cycle spindle assembly checkpoint protein, MAD2.  Proceedings of the National Academy of Sciences, USA 2000;97(6):2836-2839. PubMed Abstract


Mendez A, Krasnoperova NV, Lem J, Chen J.  Functional study of rhodopsin phosphorylation in vivo.  Methods in Enzymology 2000;316:167-185. PubMed Abstract


Vanderbrink BA, Gilbride C, Aronovitz MJ, Lenihan T, Schorn G, Taylor K, Guetersloh M, Carr K, Schoen FJ, Homoud MK, Estes NAM, Wang PJ.  Safety and efficacy of a steerable temporature monitoring microwave catheter system for ventricular myocardial ablation.  Journal of Cardiovascular Electrophysiology 2000;11(3):305-310. PubMed Abstract


Bläker M, Ren Y, Seshadri L, McBride EW, Beinborn M, Kopin AS.  CCK-B/gastrin receptor transmembrane domain mutations selectively alter synthetic agonist efficacy without affecting the activity of endogenous peptides.  Molecular Pharmacology 2000;58:399-406. PubMed Abstract


Kopin AS, McBride EW, Schaffer K, Beinborn M.  CCK receptor polymorphisms: An illustration of emerging themes in pharmacogenomics.  Trends in Pharmacol Sciences 2000;21(9):346-353. PubMed Abstract

 

Patten RD, Konstam MA.  Ventricular remodeling and the renin angiotensin aldosterone system.  Congestive Heart Failure 2000;6(4):187-192.  PubMed Abstract


Karas RH, Schulte H, Pare G, Aronovitz MJ, Ohlsson C, Gustafsson J-A, Mendelsohn, ME.  Effects of estrogen on the vascular injury response in estrogen receptor α,β (double) knockout mice. (SCOR) Circulation Research 2001;89(6):534-539. PubMed Abstract


Yuhanna IS, Zhu Y, Cox BE, Hahner LD, Osborne-Lawrence S, Lu P, Marcel YL,  Anderson RGW, Mendelsohn ME, Hobbs HH, Shaul PW.  High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase. (SCOR) Nature Medicine 2001;7(7):853-857. PubMed Abstract


Karas RH, Eickels MV, Lydon JP, Roddy S, Kwoun M, Aronovitz M, Baur WE, Conneely O, O’Malley BW, Mendelsohn ME.  A Complex role for the progesterone receptor in the response to vascular injury. (SCOR) Journal of Clinical Investigation 2001;108(4):611-618. PubMed Abstract


Frederick JM, Krasnoperova NV, Hoffman K, Church-Kopish J, Ruther K, Howes K, Lem J, Baehr W.  Mutant rhodopsin transgene expressed on a null background.  Investigative Ophthalmology & Visual Science 2001;42(3):826-833. PubMed Abstract


Tan E, Wang Q, Quiambao AB, Xu X, Qtaishat NM, Peachey NS, Lem J, Fliesler SJ, Pepperberg DR, Naash MI, Al-Ubaidi MR.  The relationship between opsin overexpression and photoreceptor degeneration.  Investigative Ophthalmology & Visual Science 2001;42(3):589-600. PubMed Abstract


Calvert PD, Govardovskii VI, Krasnoperova N, Anderson RE, Lem J, Makino CL.  Membrane protein diffusion sets the speed of rod phototransduction.  Nature 2001;411:90-94. PubMed Abstract


Liang F, Dejneka N, Cohen D, Krasnoperova NV, Lem J, Maguire AM, Dudus L, Fisher KJ, Bennett J.  AAV-Mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse.  Molecular Therapy 2001;3(2):241-248. PubMed Abstract


Tibaduiza EC, Chen C, Beinborn M.  A small molecule ligand of the glucagon-like peptide 1 receptor targets its amino-terminal hormone binding domain.  Journal of Biological Chemistry 2001;276(41):37787-37793. PubMed Abstract


Mendelsohn ME, Karas RH.  The time has come to stop letting the HERS tale wag the Dogma (Editorial). (SCOR) Circulation 2001;104:2256-2259. PubMed Abstract


Azam M, Andrabi SS, Sahr KE, Kamath L, Kuliopulos A, Chishti AH.  Disruption of the mouse µ-calpain gene reveals an essential role in platelet function.  Molecular and Cellular Biology 2001;21(6):2213-2220. PubMed Abstract


Kuvin JT, Patel AR, Sliney KA, Pandian NG, Rand WM, Udelson JE, Karas RH.  Peripheral vascular endothelial function testing as a noninvasive indicator of coronary artery disease.  Journal of the American College of Cardiology 2001;38(7):1843-1849. PubMed Abstract


Patel AR, Kuvin JT, Pandian NG, Smith JJ, Udelson JE, Mendelsohn ME, Konstam MA, Karas RH.  Heart failure etiology affects peripheral vascular endothelial function after cardiac transplantation.  Journal of the American College of Cardiology 2001;37(1):195-200. PubMed Abstract


Mendelsohn ME.  Sex steroids in the cardiovascular system: Molecular mechanisms in action. In.  Cardio and HRT, 2001;Parthenon Publishing Group.Chapter 11:87-93.


Kuvin JT, Patel AR, Karas RH.  Need for standardization of noninvasive assessment of vascular endothelial function.  American Heart Journal 2001;141(3):327-328. PubMed Abstract


Hata A.  TGF β Signaling and Cancer.  Experimental Cell Research 2001;264(1):111-116. PubMed Abstract


Kamath L, Meydani A, Foss F, Kuliopulos A.  Signaling from protease-activated receptor-1 inhibits migration and invasion of breast cancer cells.  Cancer Research 2001;61:5933-5940. PubMed Abstract


Wyckoff  MH, Chambliss KL, Mineo C, Yuhanna IS, Mendelsohn ME, Mumby SM, Shaul PW.  Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Gαι. (SCOR) Journal of Biological Chemistry 2001;276(29):27071-27076. PubMed Abstract


Karas AZ, Aronovitz M, Wolfe EM, Karas RH.  Diminished body weight and activity patterns in mice following surgery: Implications for post procedural pain/distress inlaboratory animals.  Comtemp Top Lab Animal Sciences 2001;40(4):83-83.


Mosca L, Collins P, Herrington DM, Mendelsohn ME, Pasternak RC, Robertson RM, Schenck-Gustafsson K, Smith SC, Taubert KA, Wenger NK.  Hormone replacement therapy and cardiovascular disease: A statement for healthcare pofessionals from the American Heart Association. (SCOR) Circulation 2001;104:499-503. PubMed Abstract


Nuedling S, Karas RH, Mendelsohn ME, Katzenellenbogen JA, Katzenellenbogen BS, Meyer R, Vetter H, Grohe C.  Activation of estrogen receptor β is a prerequisite for estrogen-dependent upregulation of nitric oxide synthases in neonatal rat cardiac myocytes. (SCOR) Federation of European Biochemical Societies Letters 2001;25085:1-6. PubMed Abstract


Aikawa R, Huggins GS, Snyder RO.  Cardiomyocyte-specific gene expression following recombinant adeno-associated viral vector transduction.  Journal of Biological Chemistry 2002;277(21):18979-18985. PubMed Abstract


Hao W, Wenzel A, Obin MS, Chen C-K, Brill E, Krasnoperova NV, Eversole-Cire P, Kleyner Y, Taylor A, Simon MI, Grimm C, Remé CE, Lem J.  Evidence for two apoptotic pathways in light-induced retinal degenerations.  Nature 2002;Genetics 32(2):254-260. PubMed Abstract


Woodruff ML, Sampath AP, Matthews HR, Krasnoperova NV, Lem J, Fain GL.  Measurement of cytoplasmic calcium concentration in the rods of wild-type and transducin knock-out mice.  Journal of Physiology 2002;542(3):843-854. PubMed Abstract


Covic L, Gresser AL, Talavera J, Swift S, Kuliopulos A.  Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides.  Proceedings of the National Academy of Sciences, 2002;USA 99(2):643-648. PubMed Abstract


Covic L, Misra M, Badar J, Singh C, Kuliopulos A.  Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation.  Nature Medicine 2002;8(10):1161-1165. PubMed Abstract


Pare G, Krust A, Karas RH, Dupont S, Aronovitz M, Chambon P, Mendelsohn ME.  Estrogen Receptor-α mediates the protective effects of estrogen against vascular injury. (SCOR) Circulation Research 2002;90:1087-1092. PubMed Abstract


Kuvin J, Ramet M, Patel A, Pandian N, Mendelsohn M, Karas R.  A novel mechanism for the beneficial vascular effects of high-density lipoprotein cholesterol: Enhanced vasorelaxation and increased endothelial nitric oxide synthase expression. (SCOR) American Heart Journal 2002;144:165-172. PubMed Abstract


Hearn MG, Ren Y, McBride EW, Reveillaud I, Beinborn M, Kopin AS.  A drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants.  Proceedings of the National Academy of Sciences, USA 2002;99(22):14554-14559. PubMed Abstract


Chen D, Zhao C-M, Al-Haider W, Hakanson R, Rehfeld JF, Kopin AS.  Differentiation of gastric ECL cells is altered in CCK(2) receptor-deficient mice.  Gastroenterology 2002;123(2):577-585. PubMed Abstract


Joost O, Wilk JB, Cupples LA, Harmon M, Shearman AM, Baldwin CT, O'Connor GT, Myers RH, Gottlieb DJ.  Genetic loci influencing lung function: A genomewide scan in the framingham study. (SCOR) American Journal of Respiratory and Critical Care Medicine 2002;165:795-799. PubMed Abstract


Jordan B, Charest A, Dowd JF, Blumenstiel JP, Yeh R-F, Osman A, Housman DE, Landers JE.  Genome complexity reduction for SNP genotyping analysis. (SCOR) Proceedings of the National Academy of Sciences, 2002;USA 99(5):2942-2947. PubMed Abstract


Mishell DR, Mendelsohn ME.  Introduction: The role of hormone replacement therapy in prevention and treatment of cardiovascular disease in postmenopausal women. (SCOR) The American Journal of Cardiology 2002;89(12A):1E-4E. PubMed Abstract


Zhu Y, Bian Z, Lu P, Karas RH, Bao L, Cox D, Hodgin J, Shaul PW, Thoren P, Smithies O, Gustafsson J-A, Mendelsohn ME.  Abnormal vascular function and hypertension in mice deficient in estrogen receptor β. (SCOR) Science 2002;295:505-508. PubMed Abstract


Patten RD, Aronovitz MJ, Bridgeman P, Pandian NG.  Use of pulse wave and color flow doppler echocardiography in mouse models of human disease.  Journal of the American Society of Echocardiography 2002;15:708-714. PubMed Abstract


Force T, Haq S, Kilter H, Michael A.  Apoptosis signal-regulating kinase/nuclear factor-κB: A novel signaling pathway regulates cardiomyocyte hypertrophy (Editorial).  Circulation 2002;105:402-404. PubMed Abstract


Lyubarsky AL, Lem J, Chen J, Falsini B, Iannaccone A, Pugh Jr EN.  Functionally rodless mice: Transgenic models for the investigation of cone function in retinal disease and therapy.  Vision Research 2002;42:401-415. PubMed Abstract


Sherman TS, Chambliss KL, Gibson LL, Pace MC, Mendelsohn ME, Pfister SL, Shaul PW.  Estrogen acutely activates prostacyclin synthesis in ovine fetal pulmonary artery endothelium. (SCOR) American Journal of Respiratory Cell and Molecular Biology 2002;26(5):610-616. PubMed Abstract


Bao L, Rapin AM, Holmstrand EC, Cox DH.  Elimination of the BK(Ca) channel's high-affinity Ca(2+) sensitivity.  The Journal of General Physiology 2002;120:173-189. PubMed Abstract


Mendelsohn ME.  Genomic and nongenomic effects of estrogen in the vasculture. (SCOR) The American Journal of Cardiology 2002;90(suppl):3F-6F. PubMed Abstract


Karas RH.  Animal models of the cardiovascular effects of exognous hormones. (SCOR) The American Journal of Cardiology 2002;90(suppl):22F-25f. PubMed Abstract


Ihionkhan CE, Chambliss KL, Gibson LL, Hahner LD, Mendelsohn ME, Shaul PW.  Estrogen causes dynamic alterations in endothelial estrogen receptor expression.  Circulation Research 2002;91(9):814-820. PubMed Abstract


Saba S, Zhu W, Aronovitz MJ, Estes NAM, Wang PJ, Mendelsohn ME, Karas RH.  Effects of estrogen on cardiac electrophysiology in female mice. (SCOR) Journal of Cardiovascular Electrophysiology 2002;13:276-280. PubMed Abstract


Blaustein RO.  Kinetics of tethering quaternary ammonium compounds to K+ channels.  The Journal of General Physiology 2002;120:203-216. PubMed Abstract


Covic L, Singh C, Smith H, Kuliopulos A.  Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak Syndrome.  Thrombosis and Haemostasis 2002;87:722-727. PubMed Abstract


Holubkov R, Karas RH, Pepine CJ, Rickens CR, Reicheck N, Rogers WJ, Sharaf BL, Sopko G, Merz NB, Kelsey SF, McGorray SP, Reis SE.  Large brachial artery diameter is associated with angiographic coronary artery disease in women.  American Heart Journal 2002;143(5):802-807. PubMed Abstract


Lu Q, Ebling H, Mittler J, Baur WE, Karas RH.  MAP kinase mediates growth factor-induced nuclear translocation of estrogen receptor α.  Federation of European Biochemical Societies Letters 2002;516:1-8. PubMed Abstract