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Molecular Cardiology Research Institute
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2003 Publications

Lu Q, Surks HK, Ebling H, Baur WE, Brown D, Pallas DC, Karas, RH.  Regulation of estrogen receptor α-mediated transcription by a directinteraction with protein phosphatase 2A.  Journal of Biological Chemistry 2003;278(7):4639-4645. PubMed Abstract


Patel AR, Kuvin JT, DeNofrio D, Kinan D, Sliney KA, Eranki KP, Pandian NG, Udelson JE, Konstam MA, Karas RH.  Peripheral vascular endothelial function correlates with exercise capacity in cardiac transplant recipients.  The American Journal of Cardiology 2003;91(7):897-899. PubMed Abstract


Abourjaily HM, Alsheikh-Ali AA, Karas RH.  Comparison of the frequency of adverse events in patients treated with atorvastatin or simvastatin.  The American Journal of Cardiology 2003;91(8):999-1002. PubMed Abstract


Ren Y, Blaker M, Seshadri L, McBride EW, Beinborn M, Kopin AS.  Conserved cholecystokinin receptor transmembrane domain IV amino acids confer peptide affinity.  Journal of Molecular Neuroscience 2003;20:115-123. PubMed Abstract


Lee H-Y, Srinivas H, Xia D, Lu Y, Superty R, LaPushin R, Gomez-Manzano C, Gal AM, Walsh GL, Force T, Ueki K, Mills GB, Kurie JM.  Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent pathways cooperate to maintain lung cancer cell survival.  Journal of Biological Chemistry 2003;278(26):23630-23638. PubMed Abstract


Ramet ME, Ramet M, Lu Q, Nickerson M, Savolainen MJ, Malzone A, Karas RH.  High-density lipoprotein increases the abundance of eNOS protein in human vascular endothelial cells by increasing its half-life.  Journal of the American College of Cardiology 2003;41(12):2288-2297. PubMed Abstract


Patten RD, Aronovitz MJ, Einstein M, Lambert M, Pandian NG, Mendelsohn ME, Konstam MA.  Effects of angiotensin II receptor blockade versus angiotensin-converting-enzyme inhibition on ventricular remodelling following myocardial infarction in the mouse.  Clinical Science (Lond) 2003;104(2):109-118. PubMed Abstract


Haq S, Kilter H, Michael A, Tao J, O'Leary E, Sun XM, Walters B, Bhattacharya K, Chen X, Cui L, Andreucci M, Rosenzweig A, Guerrero JL, Patten R, Liao R, Molkentin J, Picard M, Bonventre JV, Force T.  Deletion of Cytosolic phospholipase A(2) promotes striated muscle growth.  Nature Medicine 2003;9(7):944-951. PubMed Abstract


Kuvin JT, Karas RH.  Clinical utility of endothelial function testing: Ready for prime time?  Circulation 2003;107(25):3243-3247. PubMed Abstract


Hattar S, Lucas RJ, Mrosovsky N, Thompson S, Douglas RH, Hankins MW, Lem J, Biel M, Hofmann F, Foster RG, Yau K-W.  Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice.  Nature 2003;424:76-81. PubMed Abstract


Takahashi S, Mendelsohn ME.  Calmodulin-dependent and -independent activation of endothelial nitric-oxide synthase by heat shock protein 90. (SCOR) Journal of Biological Chemistry 2003;278(11):9339-9344. PubMed Abstract


Kopin AS, McBride EW, Chen C, Freidinger RM, Chen D, Zhao C-M, Beinborn M.  Identification of a series of CCK-2 receptor nonpeptide agonists: Sensitivity to stereochemistry and a receptor point mutation.  Proceedings of the National Academy of Sciences, USA 2003;100(9):5525-5530. PubMed Abstract


Mendez A, Lem J, Simon M, Chen J.  Light-dependent translocation of arrestin in the absense of rhodopsin phosphorylation and transducin signaling.  Journal Neurosci 2003;23(8):3124-3129. PubMed Abstract


Li L, Ouyang B, Choukroun G, Matyal R, Mascarenhas M, Jafari B, Bonventre JV, Force T, Quinn DA.  Stretch-induced IL-8 depends on C-Jun NH2-Terminal and nuclear factor-κB-inducing kinases.  American Journal Physiol - Lung Cellular and Molecular Physiology 2003;285(2):L464-L475. PubMed Abstract


Doran AC, Wan Y-P, Kopin AS, Beinborn M.  Established theory of radiation-induced decay is not generalizable to bolton-hunter labeled peptides.  Biochemical Pharmacology 2003;65:1515-1520. PubMed Abstract


Kuvin JT, Patel AR, Sliney KA, Pandian NG, Sheffy J, Schnall RP, Karas RH, Udelson JE.  Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude.  American Heart Journal 2003;146(1):168-174. PubMed Abstract


Kuvin JT, Karas RH.  The effects of LDL reduction and HDL augmentation on physiologic and inflammatory markers.  Current Opinion in Cardiology 2003;18(4):295-300. PubMed Abstract


Brill E, Patnala S, Lem J, Obin M.  Bright light induces retinal degeneration by a transducin-independent mechanism. In.  Advances in Experimental Medicine and Biology 2003;Vol. 533, Retinal Degenerations: Mechanisms and Experimental Therapy, LaVail MM, Hollyfield JG, Anderson RE (eds.), Plenum Publishers.533:213-219. PubMed Abstract


Karas RH, Clarkson TB.  Considerations in interpreting the cardiovascular effects of hormone replacement therapy observed in the WHI: Timing is everything.  Menopausal Medicine 2003;10:8-12.


Takahashi S, Mendelsohn ME.  Synergistic activation of endothelial Nitric-oxide synthase (eNOS) by HSP90 and Akt: Calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-BOUND eNOS complex. (SCOR) Journal of Biological Chemistry 2003;278(33):30821-30827. PubMed Abstract


Makino CL, Wen X-H, Lem J.  Piecing together the timetable for visual transduction with transgenic animals.  Current Opinion in Neurobiology 2003;13(4):404-412. PubMed Abstract


Woodruff ML, Wang Z, Chung H, Redmond M, Fain G, Lem J.  Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis.  Nature Genetics 2003;35(2):158-164. PubMed Abstract 


Xu D, Kyriakis JM.  Phosphatidyl inositol-3’OH kinase-dependent activation of renal mesangial cell ki-ras and ERK by advanced glycation end products.  Journal of Biological Chemistry 2003;278(41):39349-39355. PubMed Abstract


Kuvin JT, Patel AR, Sidhu M, Rand WM, Sliney KA, Pandian NG, Karas RH.  Relation between high-density lipoprotein cholesterol and peripheral vasomotor function.  American Journal of Cardiology 2003;92:275-279. PubMed Abstract


Andreucci M, Michael A, Kramers C, Park KM, Chen A, Matthaeus T, Alessandrini A, Haq S, Force T, Bonventre JV.  Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1.  Kidney International 2003;64(4):1189-1198. PubMed Abstract


Balk EM, Lau J, Goudas LC, Jordan HS, Kupelnick BA, Kim LU, Karas RH.  Effects of statins on nonlipid serum markers associated with cardiovascular disease: A systematic review.  The Annals of Internal Medicine 2003;139(8):670-682. PubMed Abstract


Seki K, Fujimori T, Savagner P, Hata A, Aikawa T, Ogata N, Nabeshima Y, Lee K.  Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan.  Journal of Biological Chemistry 2003;278(43):41862-41870. PubMed Abstract


Kienker PK, Jakes KS, Blaustein RO, Miller C, Finkelstein A.  Sizing the protein translocation pathway of colicin Ia channels.  The Journal of General Physiology 2003;22:161-176. PubMed Abstract


Bruna A, Nicolas M, Munoz A, Kyriakis JM, Caelles C.  Glucocorticoid receptor-JKN interaction mediates inhibition of the JNK pathway by glucocorticoids.  The EMBO Journal 2003;22(22):6035-6044. PubMed Abstract


Kyriakis JM.  At the crossroads: AMP-activated kinase and the LKBI tumor suppressor link cell proliferation to metabolic regulation.  Journal of Biology 2003;2(4):Article 26. PubMed Abstract


Roelen BA, Cohen OS, Raychowdhury MK, Chadee DN, Zhang Y, Kyriakis JM, Alessandrini AA, Lin HY.  Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-β-induced nuclear accumulation.  American Journal Physiology - Cell Physiology 2003;285(4):C823-C830. PubMed Abstract


Kuliopulos A, Covic L.  Blocking receptors from the inside: Peducin-based intervention of PAR signaling and thrombosis.  Life Sciences 2003;74:255-262. PubMed Abstract


Shearman AM, Cupples LA, Demissie S, Peter I, Schmid CH, Karas RH, Mendelsohn ME, Housman DE, Levy D.  Association between estrogen receptor α gene variation and cardiovascular disease. (SCOR) The Journal of the American Medical Association 2003;290(17):2263-2270. PubMed Abstract


Ku M, Stewart S, Hata A.  Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes.  Biochemical and Biophysical Research Communications 2003;311(3):702-707. PubMed Abstract


Mendelsohn ME, Rosano GMC.  Hormonal regulation of normal vascular tone in males. (SCOR) Circulation Research 2003;93(12):1142-1145. PubMed Abstract


Pourati I, Kimmelstiel C, Rand W, Karas RH.  Statin use is associated with enhanced collteralization of severely diseased coronary arteries.  American Heart Journal 2003;146(5):876-881. PubMed Abstract


Welzig CM, Shin D-G, Park H-J, Kim Y-J, Saul JP, Galper JB.  Lipid lowering by pravastatin increases parasympathetic modulation of heart rate: Gαι2, a possible molecular marker for parasympathetic responsiveness.  Circulation 2003;108(22):2743-2746. PubMed Abstract


Udelson JE, Patten RD, Konstam MA.  New concepts in post-infarction ventricular remodeling.  Reviews in Cardiovascular Medicine 2003;4(3):S3-S12. PubMed Abstract


Martemyanov KA, Lishko PV, Calero N, Keresztes G, Sokolov M, Strissel KJ, Leskov IB, Hopp JA, Kolesnikov AK, Chen CK, Lem J, Heller S, Burns ME, Arshavsky VY.  The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo.  Journal Neurosci 2003;23(32):10175-10181. PubMed Abstract


Jacques SL, Kuliopulos A.  Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage.  Biochem Journal 2003;376:733-740. PubMed Abstract


Covic L, Jacques SL, Kuliopulos A.  Inhibition of platelet thromboxane receptor function by a thrombin receptor-targeted pepducin.  Nature Medicine 2003;9(12):1447-1448.


Seeley S, Covic L, Jacques SL, Sudmeier J, Baleja JD, Kuliopulos A.  Structural basis for thrombin activation of a protease-activated receptor: Inhibition of intramolecular liganding.  Chemistry and Biology 2003;10(11):1033-104. PubMed Abstract


Surks HK, Richards CT, Mendelsohn ME.  Myosin phosphatase-RhoA interacting protein: A new member of the myosin phosphatase complex that directly binds RhoA. (SCOR) The Journal of Biological Chemistry 2003;278(51):51484-51493. PubMed Abstract


Mendelsohn ME.  WHI Publishes additional data analysis regarding CHD effects with EPT (Commentary). (SCOR) North American Menopause Society First-to-Know Series, 2003.


Morin DP, Konstam MA, Mendelsohn ME, Udelson JE.  Heart failure in women: Epidemiology, gender differences in pathophysiology, and implecations for therapy. In. (SCOR) Women and Coronary Disease, 2003;Shaw LJ, Redberg RF (eds.), Humana Press.Chapter 6:65-91.


Tang M, Wang G, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME.  Regulator of G-protein signaling 2 mediator vascular smooth muscle relaxation and blood pressure. (SCOR) Nature Medicine 2003;9(12):1506-1512. PubMed Abstract


Konstam MA, Patten RD.  Inhibition of the renin-angiotensin system. In.  Heart Failure Management: A Companion to Braunwald’s Heart Disease, 2003;W.B. Saunders, New York.Chapter 38:603-618.


Van Eickels M, Patten RD, Aronovitz MJ, Alsheikh-Ali A, Gostyla K, Celestin F, Grohe C, Mendelsohn ME, Karas RH.  17-β-estradiol increases cardiac remodeling and mortality in mice with myocardial infarction.  See correction at volume 42(1). (SCOR) Journal of the American College of Cardiology 2003;41(11):2084-2092. PubMed Abstract


Thompson PD, Clarkson P, Karas RH.  Statin-associated myopathy.  The Journal of the American Medical Association 2003;289(13):1681-1690. PubMed Abstract


Surks HK, Mendelsohn ME.  Dimerization of cGMP-dependent protein kinase 1β and the myosin binding subunit of myosin phosphatase: Role of leucine zipper domains. (SCOR) Cellular Signalling 2003;15(10):937-944. PubMed Abstract


Kuvin JT, Gokce N, Holbrook M, Hunter LM, Patel AR, Sliney KA, Craven DE, Grayston JT, Keaney JF, Karas RH, Vita JA.  Effect of short-term antibiotic treatment on chlamydia pneumoniae and peripheral endothelial function.  The American Journal of Cardiology 2003;91(6):732-735. PubMed Abstract


Haq S, Michael A, Andreucci M, Bhattacharya K, Dotto P, Walters B, Woodgett J, Kilter H, Force T.  Stabilization of β-catenin by a wnt-independent mechanism regulates cardiomyocyte growth.  Proceedings of the National Academy of Sciences, USA 2003;100(8):4610-4615. PubMed Abstract