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Molecular Cardiology Research Institute
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2004 Publications

Seki K, Hata A.  Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathway.  The Journal of Biological Chemistry 2004;279(18):18544-18549. PubMed Abstract


Wang DQ, Schmitz F, Kopin AS, Carey MC.  Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis.  The Journal of Clinical Investigation 2004;114(4):521-528. PubMed Abstract


Finlay GA, York B, Karas RH, Fanburg BL, Zhang H, Kwiatkowski DJ, Noonan DJ.  Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of PDGFR-β and ERK-1/2.  The Journal of Biological Chemistry 2004;279(22):23114-23122. PubMed Abstract


Young CE, Karas RH, Kuvin JT.  High-density lipoprotein cholesterol and coronary heart disease.  Cardiology in Review 2004;12(2):107-119. PubMed Abstract


Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S.  Early hematopoietic zinc finger protein (EHZF), the human homologue to mouse Evi3, is highly expressed in primitive human hematopoietic cells.  Blood 2004;103(6):2062-2070. PubMed Abstract


Lem J, Fain GL.  Constitutive opsin signaling:  Night blindness or retinal degeneration?  Trends in Molecular Medicine 2004;10(4):150-157. PubMed Abstract


Michael A, Haq S, Chen X, Hsich E, Cui L, Walters B, Shao Z, Bhattacharya K, Kilter H, Huggins G, Andreucci M, Periasamy M, Solomon RN, Liao R, Patten R, Molkentin JD, Force T.  Glycogen synthase kinase-3β regulates normal post-natal cardiac growth, calcium homeostasis and diastolic function of the heart.  The Journal of Biological Chemistry 2004;279(20):21383-21393. PubMed Abstract


Wang Y, El-Zaru MR, Surks HK, Mendelsohn ME.  Formin homology domain protein FHOD1 is a cyclic GMP-dependent protein kinase 1α binding protein and substrate in vascular smooth muscle cells.  The Journal of Biological Chemistry 2004;279(23):24420-24426. PubMed Abstract


Goruppi S, Kyriakis JM.  The pro-hypertrophic bHLH protein p8 is degraded by the ubiquitin proteasome system in a protein kinase-B/Akt and glycogen synthase kinase-3-dependent manner, while endothelin induction of p8 mRNA and renal mesangial cell hypertrophy require NFAT4.  The Journal of Biological Chemistry 2004;279(20):20950-20958. PubMed Abstract


Bao L, Kaldany C, Holmstrand EC, Cox DH.  Mapping the BKCa channels "Ca2+ bowl": Side-chains essential for Ca2+ sensing.  Journal of General Physiology 2004;123(5):475-489. PubMed Abstract


Bi S, Scott KA, Kopin AS, Moran TH.  Differential roles for cholecystokinin-A receptors in energy balance in rats and mice.  Endocrinology 2004;145(8):3873-3880. PubMed Abstract


Takabayashi T, Shimizu S, Clark BD, Beinborn M, Burke JF, Gelfand JA.  Interleukin-1 upregulates anaphylatoxin receptors on mononuclear cells.  Surgery 2004;135(5):544-554. PubMed Abstract


Danciger M, Lyon J, Worrill D, Hoffman S, Lem J, Reme CE, Wenzel A, Grimm C.  New retinal light damage QTL in mice with the light-sensitive RPE65 LEU variant.  Mammalian Genome 2004;15(4):277-283. PubMed Abstract


Alsheikh-Ali AA, Karas RH.  Adverse events with concomitant use of simvastatin or atorvastatin and thiazolidinediones.  American Journal of Cardiology 2004;93(11):1417-1418. PubMed Abstract


Giacobini P, Kopin AS, Beart PM, Mercer LD, Fasolo A, Wray S.  Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons.  Journal of Neuroscience 2004;24(20):4734-4748. PubMed Abstract


Grazette LP, Boecker W, Matsui T, Semigran M, Force TL, Hajjar RJ, Rosenzweig A.  Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: Implications for herceptin-induced cardiomyopathy.  Journal of the American College of Cardiology 2004;44(11):2231-2238. PubMed Abstract


Rindi G, Leiter AB, Kopin AS, Bordi C, Solcia E.  The "normal" endocrine cell of the gut: Changing concepts and new evidences.  Annals of the New York Academy of Sciences 2004;1014:1-12. PubMed Abstract


Karas RH.  Current controversies regarding the cardiovascular effects of hormone therapy.  Clinical Obstetrics & Gynecologyl 2004;47(2):489-499. PubMed Abstract


Chadee DN, Kyriakis JM.  MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation.  Nature Cell Biology 2004;6(8):770-776. PubMed Abstract


Patten RD, Soman P.  Prevention and reversal of LV remodeling with neurohormonal inhibitors.  Current Treatment Options in Cardiovascular Medicine 2004;6(4):313-325. PubMed Abstract


Endo A, Surks HK, Mochizuki S, Mochizuki N, Mendelsohn ME.  Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase.  The Journal of Biological Chemistry 2004;279(40):42055-42061. PubMed Abstract


Naftolin F, Taylor HS, Karas RH, Brinton E, Newman I, Clarkson TB, Mendelsohn M, Lobo RA, Udelson J, Nachtigall LE, Heward CB, Hecht H, Jaff MR, Harman SM.  The Women’s Health Initiative (WHI) could not have detected cardioprotective effects of starting hormone therapy during the menopausal transition.  Fertility and Sterility 2004;81(6):1498-1501. PubMed Abstract


Naash MI, Wu TH, Chakraborty D, Fliesler SJ, Ding XQ, Nour M, Peachey NS, Lem J, Qtaishat N, Al-Ubaidi MR, Ripps H.  Retinal abnormalities associated with the G90D mutation in opsin.  The Journal of Comparative Neurology 2004;478(2):149-163. PubMed Abstract


He W, Yasumatsu K, Varadarajan V, Yamada A, Lem J, Ninomyia Y, Margolskee RF, Damak S.  Umami taste responses are mediated by α-transducin and α-gustducin.  Journal of Neuroscience 2004;24(35):7674-7680. PubMed Abstract


Patten RD, Pourati I, Aronovitz MJ, Baur J, Celestin F, Chen X, Michael A, Haq S, Neudling S, Grohe C, Force T, Mendelsohn ME, Karas RH.  17β-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling. (SCOR) Circulation Research 2004;95(7):692-699. PubMed Abstract


Friedrich EB, Liu E, Sinha S, Cook S, Milstone DS, MacRae CA, Mariotti M, Kuhlencordt PJ, Force T, Rosenzweig A, St-Arnaud R, Dedhar S, Gerszten RE.  Integrin-linked kinase regulates endothelial cell survival and vascular development.  Molecular and Cellular Biology 2004;24(18):8134-8144. PubMed Abstract


Liu P, Konstam MA, Force T.  Highlights of the 2003 scientific sessions of the Heart Failure Society of America.  Journal of the American College of Cardiology 2004;43(6):1103-1109. PubMed Abstract


Zhong J, Kyriakis JM.  Germinal center kinase is required for optimal JNK activation by TLR agonists and is regulated by the ubiquitin proteasome system and agonist-induced, TRAF6-dependent stabilization.  Molecular and Cellular Biology 2004;24(20):9165-9175. PubMed Abstract


Alsheikh-Ali AA, Kuvin JT, Karas RH.  Risk of adverse events with fibrates.  American Journal of Cardiology 2004;94(7):935-938. PubMed Abstract


Chadee DN, Kyriakis JM.  A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation.  Cell Cycle 2004;3(10):1225-1226. PubMed Abstract


Noguchi T, Hunlich M, Camp PC, Begin KJ, El-Zaru M, Patten R, Leavitt BJ, Ittleman FP, Alpert NR, LeWinter MM, VanBuren P.  Thin filament-based modulation of contractile performance in human heart failure.  Circulation 2004;110(8):982-987. PubMed Abstract


Woodruff ML, Lem J, Fain GL.  Early receptor current of wild-type and transducin knockout mice:  Photosensitivity and light-induced Ca2+ release.  The Journal of Physiology 2004;557(3):821-828. PubMed Abstract


Balk EM, Karas RH, Jordan HS, Kupelnick B, Chew P, Lau J.  Effects of statins on vascular structure and function: A systematic review.  American Journal of Medicine 2004;117(10):775-790. PubMed Abstract


Lu Q, Pallas DC, Surks HK, Baur WE, Mendelsohn ME, Karas RH.  Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial no synthase by estrogen receptor α.  Proceedings of the National Academy of Sciences, 2004;USA 101(49):17126-17131. PubMed Abstract


Beinborn M, Ren Y, Bläker M, Chen C, Kopin AS.  Ligand function at constitutively active receptor mutants is affected by two distinct yet interacting mechanisms.  Molecular Pharmacology 2004;65(3):753-760. PubMed Abstract


Blaustein BO, Miller C.  Ion channels: Shake, rattle or roll?  Nature 2004;427:499-500. PubMed Abstract


Mosca L, Appel LJ, Benjamin EJ, Berra K, Chandra-Strobos N, Fabunmi RP, Grady D, Haan CK, Hayes SN, Udelson J, Keenan NL, McBride P, Oparil S, Ouyang P, Oz MC, Mendelsohn ME, Pasternak RC, Pinn VW, Robertson RM, Schenck-Gustafsson K, Sila CA, Smith SC Jr, Sopko G, Taylor AL, Walsh BW, Wenger NK, Williams CL.  Evidence-based guidelines for cardiovascular disease prevention in women.  Circulation 2004;109:672-693; Arterioscler Thromb Vascular Biology 2004;24(3):e29-e50; Journal of the American College of Cardiology 2004;43(5):900-921. PubMed Abstract


Kyriakis JM, Liu H, Chadee DN.  Activation of SAPKs/JNKs and p38s In vitro.  Methods in Molecular Biology 2004;250:61-88. PubMed Abstract


Force T, Kuida K, Namchuk M, Parang K, Kyriakis JM.  Inhibitors of protein kinase signaling pathways: Emerging therapies for cardiovascular disease.  Circulation 2004;109(10):1196-1205. PubMed Abstract


Karas RH.  Non-genomic Actions of Hormones. In.  Principles of Sex-based Differences in Physiology, 2004;Virginia M. Miller, Meredith Hay,34:49-57.


Maron BJ, Dearani JA, Ommen SR, Maron MS, Schaff HV, Gersh BJ, Nishimura RA.  The case for surgery in obstructive hypertrophic cardiomyopathy.  Journal of the American College of Cardiology 2004;44(10):2044-2053. PubMed Abstract


Harman SM, Brinton EA, Clarkson T, Heward CB, Hecht HS, Karas RH, Judleson DR, Naftolin F.  Is the WHI relevant to HRT started in the perimenopause?  Endocrine 2004;24(3):195-202. PubMed Abstract


Macklis R, Mendelsohn ME, Mudge G.  Manual of Introductory Clinical Medicine. In.  Boston: Little, 2004;Brown & Co., Fourth Edition.