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Molecular Cardiology Research Institute
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2005 Publications

Masur K, Tibaduiza EC, Chen C, Ligon B, Beinborn M.  Basal receptor activation by locally produced glucagon-like peptide-1 contributes to maintaining β-cell function.  Molecular Endocrinology 2005;19(5):1373-1382. PubMed Abstract

 
Kuvin JT, Patel AR, Sliney KA, Pandian NG, Karas RH.  Comparison of flow-mediated dilatation of the brachial artery in coronary patients with low-density lipoprotein cholesterol levels <80 mg/dl versus patients with levels 80 to 100 mg/dl.  The American Journal of Cardiology 2005;95(1):93-95. PubMed Abstract


Mendelsohn ME.  In hypertension, the kidneys are not always the heart of the matter.  The Journal of Clinical Investigation 2005;115(4):840-844. PubMed Abstract

 
Kuvin JT, Sidhu M, Patel AR, Sliney KA, Pandian NG, Karas RH.  Pulse pressure and peripheral arterial vasoreactivity.  Journal of Human Hypertension 2005;19(6):501-502. PubMed Abstract

 
Bridgman P, Aronovitz MA, Kakkar R, Oliverio M, Coffman T, Rand W, Konstam MA, Mendelsohn ME, Patten RD.  Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1ª receptor.  American Journal of Physiology - Heart and Circulatory Physiology 2005;289(2):H586-H592. PubMed Abstract

 
Cox DH.  The BKCa channel's Ca2+-binding sites, multiple sites, multiple ions.  The Journal of General Physiology 2005;125(3):253-255. PubMed Abstract


Watanabe K, Beinborn M, Nagamatsu S, Ishida H, Takahashi S.  Menetrier’s disease in a patient with helicobacter pylori infection is linked to elevated glucagons-like peptide-2 activity.  Scandinavian Journal of Gastroenterology 2005;40(4):477-481. PubMed Abstract


Sharkey SW, Lesser JR, Zenovich AG, Maron MS, Lindberg J, Longe TF, Maron BJ.  Acute and reversible cardiomyopathy provoked by stress in women from the United States.  Circulation 2005;111(4):472-479. PubMed Abstract 

 
Dorn GW, Force T.  Protein kinase cascades in the regulation of cardiac hypertrophy.  The Journal of Clinical Investigation 2005;115(3):527-537. PubMed Abstract


Yang X, Coriolan D, Murthy V, Schultz K, Golenbock DT, Beasley D.  Proinflammatory phenotype of vascular smooth muscle cells: Role of efficient toll-like receptor 4 signaling.  American Journal of Physiology - Heart and Circulatory Physiology 2005;289(3):H1068-H1076. PubMed Abstract


Alsheikh-Ali AA, Karas RH.  Adverse events with concomitant amiodarone and statin therapy.  Preventive Cardiology 2005;8(2):95-97. PubMed Abstract


Wang Z, Wen XH, Ablonczy Z, Crouch RK, Makino CL, Lem J.  Enhanced shutoff of phototransduction in transgenic mice expressing palmitoylation- deficient rhodopsin.  The Journal of Biological Chemistry 2005;280(26):24293-24300. PubMed Abstract


Patten RD, Denofrio D, El-Zaru M, Kakkar R, Saunders J, Celestin F, Warner K, Rastegar H, Khabbaz KR, Udelson JE, Konstam MA, Karas RH.  Ventricular assist device therapy normalizes inducible nitric oxide synthase expression and reduces cardiomyocyte apoptosis in the failing human heart.  Journal of the American College of Cardiology 2005;45(9):1419-1424. PubMed Abstract  


Beinborn M, Worrall CI, McBride EM, Kopin AS.  A human glucagon-like peptide-1 receptor polymorphism results in reduced agonist responsiveness.  Regulatory Peptides 2005;130(1-2):1-6. PubMed Abstract


Mendelsohn ME, Karas RH.  Molecular and cellular basis of cardiovascular gender differences.  Science 2005;308(5728):1583-1587. PubMed Abstract


Georgescu SP, Li JH, Karas RH, Brown M, Mendelsohn ME.  Modulator recognition factor 1 (MRF1), an AT-rich interaction domain family member, is a novel co-repressor for estrogen receptor α.  Molecular Endocrinol 2005;19(10):2491-2501. PubMed Abstract


Alsheikh-Ali AA, Ambrose MS, Kuvin JT, Karas RH.  The safety of rosuvastatin as used in common clinical practice: A postmarketing analysis.  Circulation 2005;111(23):3051-3057.  PubMed Abstract


Alsheikh-Ali AA, Kuvin JT, Karas, RH.  High-density lipoprotein cholesterol in the cardiovascular equation: Does the “good” still count?  Atherosclerosis 2005;180(2):217-223.  PubMed Abstract


Huggins GS, O'Gara PT.  Clinical presentation and diagnostic evaluation of ST-segment elevation myocardial infarction. In:.  Atherothrombosis and Coronary Artery Disease, 2005;Fuster V, Topol EJ, Nabel,Chapter 50:849-866. 


Hedrich O, Patten RD, DeNofrio D.  Current treatment options for CHF Management: Focus on the renin-angiotensin-aldosterone system.  Current Treatment Options in Cardiovascular Medicine 2005;7(1):3-13, 2005. PubMed Abstract 

 
Shearman AM, Demissie S, Cupples LA, Peter I, Schmid CH, Mendelsohn ME, Ordovas J, Housman DE.  Tobacco smoking, estrogen receptor α gene variation, and small low-density lipoprotein level.  Human Molecular Genetics 2005;14(16):2405-2413.  PubMed Abstract


Demissie S, Cupples LA, Shearman AM, Gruenthal KM, Peter I, Schmid CH, Karas RH Housman DE, Mendelsohn ME, Ordovas JM.  Estrogen receptor-α variants are associated with lipoprotein size distribution and particle levels in women: The Framingham Heart Study.  Atherosclerosis, 2005;185(1):210-218.  PubMed Abstract


Ku M, Sokol SY, Wu J, Tussie-Luna MI, Roy AL, Hata A.  Positive and negative regulation of the transforming growth factor β/activin target gene goosecoid by the TFII-I family of transcription factors.  Molecular and Cellular Biology 2005;25(16):7144-7157.  PubMed Abstract


Bao L, Cox DH.  Gating and ionic currents reveal how the BKCa channel's Ca2+ sensitivity Is enhanced by its β1 subunit.  The Journal General Physiology 2005;126(4):393-412.  PubMed Abstract


Yang X, Coriolan D, Schultz K, Golenbock DT, Beasley D.  Toll-like receptor 2 mediates persistent chemokine release by chlamydia pneumoniae-infected vascular smooth muscle cells.  Arteriosclerosis, Thrombosis, and Vascular Biology 2005;25(11):2308-2314.  PubMed Abstract


Shearman AM, Cooper JA, Kotwinski PJ, Humphries SE, Mendelsohn ME, Housman DE, Miller GJ.  Estrogen receptor ª gene variation and the risk of stroke.  Stroke 2005;36(10):2281-2282.  PubMed Abstract


Fox CS, Yang Q, Cupples LA, Guo CY, Atwood LD, Murabito JM, Levy D, Mendelsohn ME, Housman DE, Shearman AM.  Sex-Specific Association Between Estrogen Receptor ª Gene Variation and Measures of Adiposity: the Framingham Heart Study.  The Journal of Clinical Endocrinology and Metabolism 2005;90(11):6257-6262.  PubMed Abstract


Kyriakis JM.  Map kinase and growth factor pathways. In:.  Endocrinology, 2005;LJ. DeGroot, JL Jameson (eds.), Elsevier, Philadelphia,Volum 1, Fifth Edition:237-275.


Maeda T, Lem J, Palczewski K, Haeseleer F.  A critical role of CaBP4 in the cone synapse.  Investigative Ophthalmology & Visual Science 2005;46(11):4320-4327.  PubMed Abstract


Peter I, Shearman AM, Vasan RS, Zucker DR, Schmid CH, Demissie S, Cupples LA, Kuvin JT, Karas RH, Mendelsohn ME, Housman DE, Benjamin EJ.  Association of estrogen receptor β gene polymorphisms with left ventricular mass and wall thickness in women.  American Journal of Hypertension 2005;18(11):1388-1395.  PubMed Abstract


Shearman AM, Demissie S, Cupples LA, Peter I, Schmid CH, Ordovas JM, Mendelsohn ME, Housman DE.  Tobacco smoking, estrogen receptor α gene variation and small low-density lipoprotein level.  Human Molecular Genetics 2005;14(16):2405-2413.  PubMed Abstract


Patten RD, Karas RH.  Cardiomyocyte apoptosis in the ischemic and failing hearts.  Drug Discovery Today: Disease Mechanisms 2005;2(1):47-53. 


Surks HK, Riddick N, Ohtani K.  M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells.  Journal of Biological Chemistry 2005;280(52):42543-4251. PubMed Abstract


D’eon TM, Souza SC, Aronovitz MA, Obin MS, Fried SK, Greenburg AS.  Estrogen regulation of adiposity and fuel partitioning: Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways.  Journal of Biological Chemistry 2005;280(43):35983-35991. 


Huggins GS, Gewirte H.  Chronic stable angina: Clinical presentation and diagnostic techniques. In:  Atherothrombosis and Coronary Artery Disease, 2005;Fuster V, Topol EJ, Nabel,Chapter 88:1301-1312. 


Xu D, Makkinje A, Kyriakis JM.  Gene 33 is an endogenous inhibitor of Epidermal Growth Factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function.  Journal of Biological Chemistry 2005;280(4):2924-2933.  PubMed Abstract


Liu P, Konstam MA, Force T.  Highlights of the 2004 scientific sessions of the Heart Failure Society of America, Toronto, ON, Canada Sept 12-15, 2004.  Journal of the American College of Cardiology 2005;45 (4):617-625.   PubMed Abstract


Jaffe IZ, Mendelsohn ME.  Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells.  Circulation Research 2005;96(6):643-650.  PubMed Abstract


Skurk C, Maatz H, Rocnik E, Bialik A, Force T, Walsh K.  Glycogen-synthase kinase3β/β-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells.  Circulation Research 2005;96(3):308-318.  PubMed Abstract


Patel AR, Kuvin JT, Sliney KA, Rand WM, Pandian NG, Karas RH.  Peripheral vascular endothelial function correlates with exercise capacity in women.  Clinical Cardiology 2005;28(9):433-436.  PubMed Abstract


Patel AR, Kuvin JT, Sliney KA, Rand WM, Chiang JC, Udelson JE, Pandian NG, Karas RH.  Gender-based differences in brachial artery flow-mediated vasodilation as an indicator of significant coronary artery disease.  American Journal of Cardiology 2005;96(9):1223-1226.  PubMed Abstract


Blow NS, Salomon RN, Garrity K, Reveillaud I, Kopin A, Jackson FR, Watnick PI.  Vibrio cholerae infection of drosophilamelanogaster mimics the human disease cholera.  PLoS Pathogens 2005;1(1):92-98.  PubMed Abstract


Liu E, Sinha S, Williams C, Cyrille M, Heller E, Snapper SB, Georgopoulos K, St-Arnaud R, Force T, Dedhar S, Gerszten RE.  Targeted deletion of integrin-linked kinase reveals a role in T cell chemotaxis and survival.  Molecular and Cellular Biology 2005;25(24):11145-11155.  PubMed Abstract


Shao Z, Bhattacharya K, Bhattacharya S, Hsich E, Park L, Walters B, Germann U, Wang YM, Mohanlal R, Kuida K, Namchuk M, Salituro F, Yao YM, Hou WM, Chen X, Aronowitz M, Tsichlis P, Force T, Kilter H.  c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury In vitro and in vivo.  Circulation Research 2005;98(1):111-118.  PubMed Abstract


Mendelsohn ME.  Viagra: Now mending hearts.  Nature Medicine 2005;11(2):115-116. PubMed Abstract

 

Maron MS, Zenovich AG, Casey SA, Link MS, Udelson JE, Aeppli DM, Maron BJ.  Significance and relationship between magnitude of left ventricular hypertrophy and heart failure symptoms in hypertrophic cardiomyopathy.  American Journal of Cardiology 2005;95(11):1329-1333.   PubMed Abstract