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Molecular Cardiology Research Institute

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2007 Publications

Holoshitz N, Alsheikh-Ali AA, Karas RH.  Relative safety of gemfibrozil and fenofibrate in the absence of concomitant cerivastatin use.  American Journal of Cardiology 2007;101(1):95-97.  PubMed Abstract


Surks HK.  cGMP-dependent protein Kinase I and smooth muscle relaxation: A tale of two isoforms.  Circulation Research 2007;101(11):1078-1080.  PubMed Abstract


Alsheikh-Ali AA, Lin JL, Abourjaily P, Ahearn D, Kuvin JT, Karas RH.  Prevalence of low high-density lipoprotein cholesterol in patients with documented coronary heart disease or risk equivalent and controlled low-density lipoprotein cholesterol.  American Journal of Cardiology 2007;100(10):1499-1501.  PubMed Abstract


Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A.  Control of phenotypic plasticity of smooth muscle cells by BMP signaling through the myocardin-related transcription factors.  The Journal of Biological Chemistry 2007;282(51):37244-37255.  PubMed Abstract


Clarkson TB, Karas RH.  Do the cardiovascular disease risks and benefits of oral versus transdermal estrogen therapy differ between perimenopausal and postmenopausal women?  Menopause 2007;14(6):963-967.  PubMed Abstract


Kim HJ, Lim HH, Rho SH, Bao L, Lee JH, Cox DH, Kim DH, Park CS.  Modulation of the Conductance-Voltage Relationship of the BKCa Channel by Mutations at the Putative Flexible Interface Between Two RCK Domains.  Biophysical Journal 2007;94(2):446-456.  PubMed Abstract


Blaustein RO.  On the Impossibility of Nonzero Reversal Potentials of Passive Pores Separating Symmetric Solutions: Comment on Haemophilus influenzae Outer Membrane Protein P5 Is Associated with Inorganic Polyphosphate and Polyhydroxybutyrate.  Biophysical Journal 2007;93(8):2978.  PubMed Abstract


Sanyal S, Karas RH, Kuvin JT.  Present-day uses of niacin: effects on lipid and non-lipid parameters.  Expert Opinion on Pharmacotherapy 2007;8(11):1711-1717.  PubMed Abstract


Riddick N, Ohtani K, Surks HK.  Targeting by myosin phosphatase-RhoA interacting protein mediates RhoA/ROCK regulation of myosin phosphatase.  Journal of Cellular Biochemistry 2007;103(4):1158-1170.  PubMed Abstract


Alsheikh-Ali AA, Maddukuri PV, Han H, Karas RH.  Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials.  Journal of the American College of Cardiology 2007;50(5):409-418.  PubMed Abstract


Huggins GS, Lepore JJ, Greytak S, Patten RD, McNamee R, Aronovitz MJ, Wang P, Reed GL.  The CREB leucine zipper regulates CREB phosphorylation, cardiomyopathy, and lethality in a transgenic model of heart failure.  American Journal of Physiology - Heart and Circulatory Physiology 2007;293(3):H1877-H1882.  PubMed Abstract


Liu G, Fortin JP, Beinborn M, Kopin AS.  Four Missense Mutations in the Ghrelin Receptor Result in Distinct Pharmacological Abnormalities.  Journal Pharmacology Experimental Therapeutics 2007;322(3):1036-1043.  PubMed Abstract


Zhong J, Kyriakis JM.  Dissection of a signaling pathway by which pathogen-associated molecular patterns (PAMPs) recruit the JNK and p38 MAPKs and trigger cytokine release.  Journal of Biological Chemistry 2007;282(33):24246-24254.  PubMed Abstract


Chan MC, Nguyen PH, Davis BN, Ohoka N, Hayashi H, Du K, Lagna G, Hata A.  A novel regulatory mechanism of the Bone Morphogenetic Protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor.  Molecular and Cellular Biology 2007;27(16):5776-5789.  PubMed Abstract


Kutcher ME, Kolyada AY, Surks HK, Herman IM.  Pericyte Rho GTPase mediates both pericyte contractile phenotype and capillary endothelial growth state.  American Journal of Pathology 2007;171(2):693-701.  PubMed Abstract


Mendelsohn ME, Karas RH.  HRT and the Young at Heart.  New England Journal of Medicine 2007;356(25):2639-2641.


Pullat RC, Gadarla MR, Karas RH, Thompson PD.  Tendon rupture associated with simvastatin/ezetimibe therapy.  American Journal of Cardiology 2007;100(1):152-153.  PubMed Abstract


Rosenzweig DH, Nair KS, Wei J, Wang Q, Garwin G, Saari JC, Chen CK, Smrcka AV, Swaroop A, Lem J, Hurley JB, Slepak VZ.  Subunit Dissociation and Diffusion Determine the Subcellular Localization of Rod and Cone Transducins.  The Journal of Neuroscience 2007;27(20):5484-5494.  PubMed Abstract


Peter I, Huggins GS, Shearman AM, Pollak A, Schmid CH, Cupples, Demissie S, Patten RD, Karas RH, Housman DE, Mendelsohn ME, Vasan RS, Benjamin EJ.  Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-α gene. Hypertension 2007;49(5):1000-1006.   PubMed Abstract


Bi S, Chen J, Behles RR, Hyun J, Kopin A, Moran TH.  Differential body weight and feeding responses to high fat diet in rats and mice lacking cholecystokinin 1 receptors.  AJP-Regulatory, Integrative and Comparative Physiology 2007;293(1):R55-R63.  PubMed Abstract


Utian WH, Archer DF, Bachmann GA, Gallagher JC, Grodstein F, Heiman, JR, Henderson VW, Hodis HN, Karas RH, Lobo RA, Manson JE, Reid RL, Schmidt PJ, Stuenkel CA.  Estrogen and progestogen use in peri- and postmenopausal women:  March 2007 position statement of the North American Menopause Society.  Menopause: Journal of the North American Menopause Society 2007;14(2):168-182.


Matthan NR, Jalbert SM, Ausman LM, Kuvin JT, Karas RH, Lichtenstein AH.  Effect of soy protein from differently processed products on cardiovascular disease risk factors and vascular endothelial function in hypercholesterolemic subjects.  The American Journal of Clinical Nutrition 2007;85(4):960-966.  PubMed Abstract


Li HJ, Haque ZK, Chen A, Mendelsohn ME. RIF-1, a novel nuclear receptor corepressor that associates with the nuclear matrix. Journal of Cellular Biochemistry 2007;102(4):1021-1035.   PubMed Abstract


Al-Fulaij MA, Ren Y, Beinborn M, Kopin A.  Identification of Amino Acid Determinants of Dopamine 2 Receptor Synthetic Agonist Function.  The Journal of pharmacology and experimental therapeutics, 2007;321(1):298-307.  PubMed Abstract


Jaffe IZ, Tintut Y, Newfell BG, Demer LL, Mendelsohn ME.  Mineralcorticoid Receptor Activation Promotes Vascular Cell Calcification.  Ateriosclerosis, Thrombosis and Vascular Biology 2007;27(4):799-805.  PubMed Abstract


O’Lone R, Knorr K, Jaffe IZ, Schaffer M, Martini P, Karas RH, Bienkowska J, Mendelsohn ME, Hansen U.  Estrogen Receptors and β Mediate Distinct Pathways of Vascular Gene Expression, Including Genes Involved in Mitochondrial Electron Transport and Generation of Reactive Oxygen Species.  Molecular Endocrinol 2007;21(6):1281-1296.  PubMed Abstract


Rajala A, Anderson RE, Ma JX, Lem J, Al-Ubaidi MR, Rajala RV.  G protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor.  Journal of Biological Chemistry 2007;282(13):9865-9873.  PubMed Abstract


Li J, Haque Z, Lu Q, Li L, Karas RH, Mendelsohn ME.  Steroid receptor coactivator-3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation.  Proceedings of the National Academy of Sciences, USA 2007;104(10):4065-4070.  PubMed Abstract


Schultz K, Murthy V, Tatro JB, Beasley D.  Endogenous Interleukin -1 promotes a proliferative and proinflammatory phenotype in human vascular smooth muscle cells.    American Journal of Physiology - Heart and Circulatory Physiology, 2007;292(6):H2927-H2934.  PubMed Abstract


Patten RD.  Cellular, molecular, and structural changes during cardiac remodeling: In.  Hosenpud JD and Greenberg BH, Editors Congestive Heart Failure, 3rd Edition, 2007;Chapter 8:128-146.


Alsheikh-Ali AA, Karas RH.  Safety of lovastatin/extended release niacin compared with lovastatin alone, atorvastatin alone, pravastatin alone, and simvastatin alone (from the United States Food and Drug Administration Adverse Event Reporting System).  American Journal of Cardiology 2006;99(3):379-381.  PubMed Abstract


Draper I, Kurshan P, McBride EW, Jackson FR, Kopin AS.  Locomotor activity is regulated by D2-like receptors in Drosophila: An anatomic and functional analysis.  Developmental Neurobiology 2007;67(3):378-393.  PubMed Abstract


Kuvin JT, Mammen A, Mooney P, Alsheikh-Ali AA, Karas RH. Assessment of peripheral vascular endothelial function in the ambulatory setting. 2007;Vascular Medicine 12(1):13-16.  PubMed Abstract


Pombo CM, Force T, Kyriakis J, Nogueira E, Fidalgo M, Zalvide J.  The GCK II and III subfamilies of the STE20 group kinases.  Frontiers in Bioscience 2007;12:850-859.  PubMed Abstract


Kyriakis JM.  The integration of signaling by multiprotein complexes containing Raf kinases.  Biochemica et Biophysica Acta 2007;1773(8):1238-1247.  PubMed Abstract


Bemelmans AP, Kostic C, Hornfeld D, Jaquet M, Crippa SV, Hauswirth WW, Lem J, Wang Z, Schorderet DE, Munier FL, Wenzel A, Arsenijevic Y.  Lentiviral vectors containing a retinal pigment epithelium specific promoter for leber congenital amaurosis gene therapy. Lentiviral gene therapy for LCA.  Advances in Experimental Medicine and Biology 2006;572:247-253.  PubMed Abstract