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Molecular Cardiology Research Institute

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2008 Publications

Meng H, Krishnaji ST, Beinborn M, Kumar K.  Influence of Selective Fluorination on the Biological Activity and Proteolytic Stability of Glucagon-like Peptide-1.  Journal of Medicinal Chemistry 2008;51(22):7303-7307.  PubMed Abstract


Murage EN, Beinborn M, Ahn JM.  Search for alpha-helical propensity in the receptor-bound conformation of glucagon-like peptide-1.  Bioorganic & Medicinal Chemistry 2008;16(23):10106-10112.  PubMed Abstract


Lavine JA, Raess PW, Davis DB, Rabaglia ME, Presley BK, Keller MP, Beinfeld MC, Kopin AS, Newgard CB, Attie AD.  Overexpression of pre-pro-cholecystokinin stimulates β-cell proliferation in mouse and human islets with retention of islet function.  Molecular Endocrinology 2008;22(12):2716-2728.  PubMed Abstract


Sweet TB, Cox DH.  Measurements of the BKCa channel's high-affinity Ca2+ binding constants: effects of membrane voltage.  The Journal of General Physiology 2008;132(5):491-505.  PubMed Abstract


Tsutsumi S, Zhang X, Takata K, Takahashi K, Karas RH, Kurachi H, Mendelsohn ME.  Differential regulation of the inducible nitric oxide synthase gene by estrogen receptors 1 and 2.  Journal of Endocrinology 2008;199(2):267-273.  PubMed Abstract


Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS.  Deletion of GSK-3β in Mice Leads to Hypertrophic Cardiomyopathy Secondary to Cardiomyoblast Hyperproliferation.  Journal of Clinical Investigation 2008;118(11):3609-3618.  PubMed Abstract


Sharma AK, Zhou GP, Kupferman J, Surks HK, Christensen EN, Chou JJ, Mendelsohn ME, Rigby AC.  Probing the interaction between the coiled-coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C-terminus of the myosin binding subunit of the myosin light chain phosphatase.  Journal of Biological Chemistry 2008;283(47):32860-32869.  PubMed Abstract


Schnoes KK, Jaffe IZ, Iyer L, Dabreo A, Aronovitz M, Newfell B, Hansen U, Rosano G, Mendelsohn ME.  Rapid recruitment of temporally distinct vascular gene sets by estrogen.  Molecular Endocrinol 2008;22(11):2544-2556.  PubMed Abstract


Anderson DS, Blaustein RO.  Preventing voltage-dependent gating of anthrax toxin channels using engineered disulfides.  The Journal General Physiology 2008;132(3):351-360.  PubMed Abstract


Utian WH, Archer DF, Bachmann GA, Gallagher C, Grodstein F, Heiman JR, Henderson VW, Hodis HN, Karas RH, Lobo RA, Manson JE, Reid RL, Schmidt PJ, Stuenkel CA.  Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause Society.  Menopause 2008;15(4 Pt 1):584-602.  PubMed Abstract


Alsheikh-AA, Trikalinos T, Kent DM,  Karas RH.  Statins, low-density lipoprotein cholesterol and risk of cancer.  Journal of the American College of Cardiology 2008;52(14):1141-1147. PubMed Abstract   Abstract 


Fernández AB, Karas RH, Alsheikh-Ali AA, Thompson PD.  Statins and interstitial lung disease: A systematic review of the literature and of FDA adverse event reports.  Chest 2008;134(4):824-830.  PubMed Abstract


Rouf R, Greytak S, Wooten EC, Wu J, Boltax J, Picard M, Svensson EC, Dillmann WH, Patten RD, Huggins GS.  Increased FOG-2 in failing myocardium disrupts thyroid hormone-dependent SERCA2 gene transcription.  Circulation Research 2008;103(5):493-501.  PubMed Abstract


Nogueira E, Fidalgo M, Molnar A, Kyriakis J, Force T, Zalvide J, Pombo CM.  SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and induces apoptotic cell death.  The Journal of Biological Chemistry 2008;283(23):16248-16258.  PubMed Abstract 


Davis BN, Hilyard AC, Lagna G, Hata A.  SMAD proteins control DROSHA-mediated microRNA maturation.  Nature 2008;454(7200):56-61.  PubMed Abstract


Ballantyne CM, Davidson MH, McKenney JM, Keller LH, Bajorunas DR, Karas RH.  Comparison of the safety and efficacy of a combination tablet of niacin extended release and simvastatin vs simvastatin monotherapy in patients with increased non-HDL Cholesterol (from the SEACOAST I Study).  American Journal of Cardiology 2008;101(10):1426-1436.  PubMed Abstract


Caprio M, Newfell BG, la Sala A, Baur W, Fabbri A, Rosano G, Mendelsohn ME, Jaffe IZ.  Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion.  Circulation Research 2008;102(11):1359-1367.  PubMed Abstract


Peter I, Kelley-Hedgepeth A, Fox CS, Cupples LA, Huggins GS, Housman DE, Karas RH, Mendelsohn ME, Levy D, Murabito JM.  Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels.  The Journal of Clinical Endocrinology & Metabolism 2008;93(7):2779-2785.  PubMed Abstract


Michael S, Surks HK, Wang Y, Zhu Y, Blanton R, Jamnongit M, Aronovitz M, Baur W, Ohtani K, Wilkerson MK, Bonev AD, Nelson MT, Karas RH, Mendelsohn ME.  High blood pressure arising from a defect in vascular function.  Proceedings of the National Academy of Sciences, USA 2008;105(18):6702-6707.  PubMed Abstract


Alsheikh-AA, Karas RH.  The safety of niacin in the US Food and Drug Administration adverse event reporting database.  American Journal of Cardiology 2008;101(8):S9-S13.


Wong JY, Huggins GS, Debidda M, Munshi NC, De Vivo I.  Dichloroacetate induces apoptosis in endometrial cancer cells.  Gynecologic Oncology 2008;109(3):394-402.  PubMed Abstract


Karas RH, Kashyap M, Knopp R, Keller L, Bajorunas DR, Davidson M.  Long-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: The OCEANS Study.  American Journal of Cardiovascular Drugs 2008;8(2):69-81.  PubMed Abstract


Kelley-Hedgepeth A, Peter I, Kip KE, Montefusco MC, Kogan S, Cox D, Ordovas JM, Levy D, Reis SE, Mendelsohn ME, Housman D, Huggins GS.  The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with β-blockade.  Journal of Human Hypertension 2008;22(7):512-515.  PubMed Abstract


Patten RD, Pourati I, Aronovitz MJ, Alsheikh-Ali A, Eder S, Force T, Mendelsohn ME, Karas RH.  17 β-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload.  Journal of Cardiac Failure 2008;14(3):245-253.  PubMed Abstract


Ballantyne CM, Davidson MH, McKenney JM, Keller LH, Bajorunas DR, Karas RH.  Comparison of the efficacy and safety of a combination tablet of niacin extended-release and simvastatin with simvastatin 80 mg monotherapy: The SEACOAST II (high-dose) study.  Journal of Clinical Lipidology 2008;2(2):79-80.


Stanic D, Paratcha G, Ledda F, Herzog H, Kopin AS, Hökfelt T.  Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain.  Proceedings of the National Academy of Sciences 2008;105(9):3610-3615.  PubMed Abstract


Suryadevara RS, Karas RH, Kuvin JT.  Use of extended-release niacin in clinical practice.  Future Lipidology 2008;3(1):9-16.  Abstract


Lem J, Rwayitare K.  Transgenic strategies for the analysis of photoreceptor function. In: Signal Transduction in the Retina.   S. Fliesler and O. Kisselev, 2008;Chapter 7:145-161.


Al-Fulaij MA, Ren Y, Beinborn M, Kopin AS.  Pharmacological Analysis of Human D1 and D2 Dopamine Receptor Missense Variants.  Journal of Molecular Neuroscience 2008;34(3):211-223.  PubMed Abstract


Alsheikh-Ali AA, Karas RH.  Reply.  Journal of the American College of Cardiology 2008;51(1):92. 


Park HJ, Georgescu SP, Du C, Madias C, Aronovitz MJ, Welzig CM, Wang B, Begley U, Zhang Y, Blaustein RO, Patten RD, Karas RH, Van Tol HH, Osborne TF, Shimano H, Liao R, Link MS, Galper JB.  Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.  Journal of Clinical Investigation 2008;118(1):259-271.  PubMed Abstract 


Brill E, Malanson KM, Radu RA, Boukharov, NV, Wang Z, Chung H-Y, Lloyd MB, Bok D, Travis GH, Obin M, Lem J.  A novel form of transducin-dependent retinal degeneration: Accelerated retinal degeneration in the absence of rod transducin.  Investigative Ophthalmology & Visual Science 2007;48(12):5445-5453.  PubMed Abstract 


Patten RD.  Models of gender differences in cardiovascular disease.  Drug Discovery Today: Disease Models 2007;4(4):227-232.