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Molecular Cardiology Research Institute

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2010 Publications

Goldstein C, Schroeder JC, Fortin JP, Goss JM, Schaus SE, Beinborn M, Kopin AS.  Two Naturally Occurring Mutations in the Type 1 Melanin Concentrating Hormone Receptor Abolish Agonist-Induced Signaling.  Journal of Pharmacology and Experimental Therapeutics 2010; 335(3):799-806.  PubMed Abstract


Gurley SB, Griffiths RC, Mendelsohn ME, Karas RH, Coffman TM.  Renal actions of RGS2 control blood pressure.  Journal of the American Society of Nephrology 2010; 21(11):1847-1851.  PubMed Abstract


Davis BN, Hata A.  Mechanisms of control of microRNA biogenesis.  The Journal of Biochemistry 2010; 148(4):381-392.  PubMed Abstract


Chadee DN, Kyriakis JM.  Activation of SAPK/JNKs In Vitro.  Methods in Molecular Biology 2010; 661:59-73.  PubMed Abstract


Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A.  Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha.  Molecular Cell 2010; 39(3):373-384.  PubMed Abstract


Fortin JP, Ci L, Schroeder JC, Goldstein C, Montefusco MC, Peter I, Reis SE, Huggins GS, Beinborn M, Kopin AS.  The Mu-Opioid Receptor Variant N190K is Unresponsive to Peptide Agonists Yet Can be Rescued by Small Molecule Drugs.  Molecular Pharmacology 2010; 78(5):837-845.  PubMed Abstract


Alsheikh-Ali AA, Karas RH.  Balancing the intended and unintended effects of statins.  British Medical Journal 2010; 340:c2240.  PubMed Abstract


Brooks EL, Kuvin JT, Karas RH.  Niacin's role in the statin era.  Expert Opin Pharmacother 2010; 11(14):2291-2300.  PubMed Abstract


Mendelsohn ME, Karas RH.  Rapid progress for non-nuclear estrogen receptor signaling.  Journal of Clinical Investigation 2010; 120(7):2277-2279.  PubMed Abstract


Jafri H, Alsheikh-Ali AA, Karas RH.  Baseline and on-treatment high-density lipoprotein cholesterol and the risk of cancer in randomized controlled trials of lipid-altering therapy.  Journal of the American College of Cardiology 2010; 55(25):2846:2854.  PubMed Abstract


Santen RJ, Allred DC, Ardoin SP, Archer DF, Boyd N, Braunstein GD, Burger HG, Colditz GA, Davis SR, Gambacciani M, Gower BA, Henderson VW, Jarjour WN, Karas RH, Kleerekoper M, Lobo RA, Manson JE, Marsden J, Martin KA, Martin L, Pinkerton JV, Rubinow DR, Teede H, Thiboutot DM, Utian WH.  Postmenopausal Hormone Therapy: An Endocrine Society Scientific Statement.  Journal of Clinical Endocrinology & Metabolism 2010; 97 (7 Suppl 1):s1-s66.  PubMed Abstract


Heffernan KS, Patvardhan EA, Hession M, Ruan J, Karas RH, Kuvin JT.  Elevated augmentation index derived from peripheral arterial tonometry is associated with abnormal ventricular-vascular coupling.  Clinical Physiology and Functional Imaging 2010; 30(5):313-317.  PubMed Abstract


Kong DK, Georgescu SP, Kyriakis JM, Goruppi S.  Deficiency of transcriptional regulator p8 induces autophagy and causes impaired cardiac function.  Autophagy 2010;6(5).  PubMed Abstract


Denis GV, Nikolajczyk BS, Schnitzler GR.  An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis.  FEBS Letters 2010; 584(15):3260-3268.  PubMed Abstract


Heffernan KS, Fahs CA, Ranadive SM, Patvardhan EA.  L-arginine as a nutritional prophylaxis against vascular endothelial dysfunction with aging.  Journal of Cardiovascular Pharmacology and Therapeutics 2010; 15(1):17-23.  PubMed Abstract


Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K.  Palmitoylation stabilizes unliganded rod opsin.  Proceedings of the National Academy of Sciences, USA 2010; 107(18):8428-8433.  PubMed Abstract


Montefusco MC, Merlo K, Bryan CD, Surks HK, Reis SE, Mendelsohn ME, Huggins GS.  Little ROCK is a ROCK1 pseudogene expressed in human smooth muscle cells.  BMC Genet 2010; 11:22.  PubMed Abstract


Welzig CM, Park H-J, Karas RH, Naggar J, Estes M, Galper JB.  Differential effects of statins (Pravastatin or Simvastatin) on ventricular ectopic complexes: G¡2, A Possible molecular marker for ventricular irritability.  American Journal of Cardiology 2010; 105(8):1112-1117.  PubMed Abstract


Heffernan KS, Karas RH, Patvardhan EA, Kuvin JT.  Endothelium-dependent vasodilation is associated with exercise capacity in smokers and non-smokers.  Vascular Medicine 2009; 15(2):119-125.  PubMed Abstract


Miao L, Shi J, Wang CY, Zhu Y, Du X, Jiao H, Mo Z, Klocker H, Lee C, Zhang J.  Estrogen receptor-related receptor {alpha} mediates up-regulation of aromatase expression by prostaglandin E2 in prostate stromal cells.  Molecular Endocrinology 2010; 24(6):1175-1186.  PubMed Abstract


Kilili GK, Kyriakis JM.  Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity Via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation.  The Journal of Biological Chemistry 2010; 285(20):15076-15087.   PubMed Abstract


Kong DK, Georgescu SP, Cano C, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM, Goruppi S.  Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.  Molecular Biology of the Cell 2010; 21(8):1335-1349.  PubMed Abstract


Heffernan KS, Karas RH, Patvardhan EA, Jafri H, Kuvin JT.  Peripheral arterial tonometry for risk stratification in men with coronary artery disease.  Clinical Cardiology 2010; 33(2):94-98.  PubMed Abstract


Beinborn M, Blum A, Hang L, Setiawan T, Schroeder JC, Stoyanoff K, Leung J, Weinstock JV.  TGF-{beta} regulates T-cell neurokinin-1 receptor internalization and function.  Proceedings of the National Academy of Sciences, USA 2010; 107(9):4293-4298.  PubMed Abstract


Lavine JA, Raess PW, Davis DB, Rabaglia ME, Presley BK, Keller MP, Beinfeld MC, Kopin AS, Newgard CB, Attie AD.  Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: A cautionary note.  Molecular Endocrinology 2010; 24(2):464-467.  PubMed Abstract


Patvardhan EA, Heffernan KS, Ruan JM, Soffler MI, Karas RH, Kuvin JT.  Assessment of vascular endothelial function with peripheral arterial tonometry: Information at your fingertips?  Cardiol in Rev 2010; 18(1):20-28.  PubMed Abstract


Wooten EC, Iyer LK, Montefusco MC, Hedgepeth AK, Payne DD, Kapur NK, Housman DE, Mendelsohn ME, Huggins GS.  Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.  PLoS One 2010; 5(1):e8830.  PubMed Abstract


Heffernan KS, Napolitano CA, Maron MS, Patvardhan EA, Patel AR, Pandian NG, Karas RH, Kuvin JT.  Peripheral vascular endothelial function in patients with hypertrophic cardiomyopathy.  American Journal of Cardiology 2010; 105(1):112-115.  PubMed Abstract


Heffernan KS, Karas RH, Mooney P, Patel A, Kuvin JT.  Pulse wave amplitude is associated with brachial artery diameter: Implications for gender differences in microvascular function.  Vascular Medicine 2009; 15(1):39-45.   PubMed Abstract


Pang JJ, Gao F, Lem J, Bramblett DE, Paul DL, Wu SM.  Direct rod input to cone BCs and direct cone input to rod BCs challenge the traditional view of mammalian BC circuitry.  Proceedings of the National Academy of Sciences, USA 2009; 107(1):395-400.   PubMed Abstract


Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A.  Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression.  European Molecular Biology Organization Journal 2009; 29(3):559-573   PubMed Abstract


Pham CD, He X, Schnitzler GR.  Divergent human remodeling complexes remove nucleosomes from strong positioning sequences.  Nucleic Acids Research 2009; 38(2):400-413.  PubMed Abstract


Hata A, Davis BN.  Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus.  Cytokine & Growth Factor Reviews 2009; 20(5-6):517-521.  PubMed Abstract


Fortin JP, Schroeder JC, Zhu Y, Beinborn M, Kopin AS.  Pharmacological characterization of human incretin receptor missense variants.  Journal of Pharmacology and Experimental Therapeutics 2009 332(1):274-280  PubMed Abstract


Draper I, Tabaka ME, Jackson FR, Salomon RN, Kopin AS.  The evolutionarily conserved RNA binding protein SMOOTH is essential for maintaining normal muscle function.  Fly 2009; 3(4):1-11.  PubMed Abstract


Danilova OV, Tai AK, Mele DA, Beinborn M, Leiter AB, Greenberg AS, Perfield JW 2nd, Defuria J, Singru PS, Lechan RM, Huber BT.  Neurogenin 3-dpecific dipeptidyl peptidase-2 deficiency causes impaired glucose tolerance, insulin resistance, and visceral obesity.  Endocrinology 2009; 150(12):5240-5248.  PubMed Abstract 


Mendelsohn ME.  Estrogen actions in the cardiovascular system.  Climacteric 2009; 12 Suppl 1:18-21.  PubMed Abstract