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Molecular Cardiology Research Institute

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2011 Publications

Heffernan KS, Kuvin JT, Patel AR, Karas RH, Kapur NK. Endothelial function and soluble endoglin in smokers with heart failure.  Clin Cardiol. 2011 Dec;34(12):729-33. Epub 2011 Nov 28. Pubmed Abstract


Kapur NK, Paruchuri V, Korabathina R, Al-Mohammdi R, Mudd JO, Prutkin J, Esposito M, Shah A, Kiernan MS, Sech C, Pham DT, Konstam MA, Denofrio D. Effects of a percutaneous mechanical circulatory support device for medically refractory right ventricular failure. J Heart Lung Transplant. 2011 Dec;30(12):1360-7. Epub 2011 Aug 24. Pubmed Abstract


Heffernan KS, Patvardhan EA, Kapur NK, Karas RH, Kuvin JT. Peripheral augmentation index as a biomarker of vascular aging: an invasive hemodynamics approach. Eur J Appl Physiol. 2011 Dec 3. [Epub ahead of print] Pubmed Abstract


Davis-Dusenbery BN, Wu C, Hata A. Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2370-7. Pubmed Abstract


Wu C, So J, Davis-Dusenbery BN, Qi HH, Bloch DB, Shi Y, Lagna G, Hata A. Hypoxia Potentiates MicroRNA-Mediated Gene Silencing through Posttranslational Modification of Argonaute2. Mol Cell Biol. 2011 Dec; 31(23):4760-74. Pubmed Abstract


Georgescu SP, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM, Goruppi S. Decreased Metalloprotease 9 Induction, Cardiac Fibrosis and Higher Autophagy after Pressure Overload in Mice Lacking the Transcriptional Regulator p8. Am J Physiol Cell Physiol. 2011 Nov;301(5):C1046-56. Epub 2011 Jul 20. Pubmed Abstract


Kapur NK, Kociol RD.  Rise of the machines… and their mechanics. Catheter Cardiovasc Interv. 2011 Nov 15;78(6):962-3. (Commentary)


Gordon J, Hwang J, Carrier KJ, Jones CA, Kern QL, Moreno CS, Karas RH, Pallas DC. Protein Phosphatase 2A (PP2A) Binds Within the Oligomerization Domain of Striatin and Regulates the Phosphorylation and Activation of the Mammalian Ste20-Like Kinase Mst3. BMC Biochem. 2011 Oct 10;12(1):54. [Epub ahead of print]. Pubmed Abstract


Kiernan MS, Pham DT, Denofrio D, Kapur NK. Management of HeartWare left ventricular assist device thrombosis using intracavitary thrombolytics. J Thorac Cardiovasc Surg. 2011 Sep; 142(3):712-4. Pubmed Abstract


Peter I, Huggins GS, Ordovas JM, Haan M, Seddon JM. Evaluation of New and Established Age-Related Macular Degeneration Susceptibility Genes in the Women's Health Initiative Sight Exam (WHI-SE) Study. Am J Ophthalmol. 2011 Sep 8. [Epub ahead of print] Pubmed Abstract


Shapiro MD , Bagley J, Latz J, Godwin JG, Ge X, Tullius SG, Iacomini J. MicroRNA expression data reveals a signature of kidney damage following ischemia reperfusion injury. PLoS One. 2011 Aug 15; 6(8):e23011. [Epub ahead of print]. Pubmed Abstract


Newfell BG, Iyer LK, Mohammad NN, McGraw AP, Ehsan A, Rosano G, Huang PL, Mendelsohn ME, Jaffe IZ. Aldosterone Regulates Vascular Gene Transcription via Oxidative Stress-Dependent and -Independent Pathways. Arterioscler Thromb Vasc Biol. 2011 Aug; 31(8):1871-80. Pubmed Abstract
Pugliese-Pires PN, Fortin JP, Arthur T, Latronico AC, Mendonca BB, Villares SM, Arnhold IJ, Kopin AS, Jorge AA. Novel inactivating mutations in the GH secretagogue receptor gene in patients with constitutional delay of growth and puberty. Eur J Endocrinol. 2011 Aug; 165(2):233-41. Pubmed Abstract


Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A. Down-regulation of Kruppel-like Factor-4 (KLF4) by MicroRNA-143/145 Is Critical for Modulation of Vascular Smooth Muscle Cell Phenotype by Transforming Growth Factor-{beta} and Bone Morphogenetic Protein 4. J Biol Chem. 2011 Aug 12; 286(32):28097-110. Pubmed Abstract

Kapur NK. A Clinical Commentary on the Articles "Strategies for Tissue Engineering Cardiac Constructs to Affect Functional Repair Following Myocardial Infarction" and "Stem Cell-Based Cardiac Tissue Engineering" : Repairing, Reprogramming, and Renewing: The Promise of Myocardial Cytotherapeutics. J Cardiovasc Transl Res. 2011 Aug 11. Pubmed Abstract

Pham CD, Sims HI, Archer TK, Schnitzler GR. Multiple Distinct Stimuli Increase Measured Nucleosome Occupancy around Human Promoters. PLoS One. 2011; 6(8):e23490. Pubmed Abstract

Kapur NK, Bian C, Lin E, Deming CB, Sperry JL, Hansen BS, Kakouros N, Rade JJ. Inhibition of transforming growth factor-β restores endothelial thromboresistance in vein grafts. J Vasc Surg. 2011 Jul 29. Pubmed Abstract

Patvardhan E, Heffernan KS, Ruan J, Hession M, Warner P, Karas RH, Kuvin JT. Augmentation index derived from peripheral arterial tonometry correlates with cardiovascular risk factors. Cardiol Res Pract. 2011; 253758. Pubmed Abstract

Bafford R, Sui XX, Park M, Miyahara T, Newfell BG, Jaffe IZ, Romero JR, Adler GK, Williams GH, Khalil RA, Conte MS. Mineralocorticoid receptor expression in human venous smooth muscle cells: a potential role for aldosterone signaling in vein graft arterialization. Am J Physiol Heart Circ Physiol. 2011 Jul; 301(1):H41-7. Pubmed Abstract

Smart-Halajko MC, Kelley-Hedgepeth A, Montefusco MC, Cooper JA, Kopin A, McCaffrey JM, Balasubramanyam A, Pownall HJ, Nathan DM, Peter I, Talmud PJ, Huggins GS; the Look AHEAD Study. ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial. BMC Med Genet. 2011 Jun 29; 12(1):89. Pubmed Abstract

McCurley A, Jaffe IZ. Mineralocorticoid receptors in vascular function and disease. Mol Cell Endocrinol. 2011 Jun 24. Pubmed Abstract

Korabathina R, Pham DT, Kapur NK. Subacute left ventricular rupture supported with a percutaneous left ventricular assist device. J Invasive Cardiol. 2011 Jun; 23(6):246-7. Pubmed Abstract


Tangri N, Alam A, Wooten EC, Huggins GS. Lack of association of Klotho gene variants with valvular and vascular calcification in Caucasians: a candidate gene study of the Framingham Offspring Cohort. Nephrol Dial Transplant. 2011 May 12. Pubmed Abstract

Wooten EC, Huggins GS. Mind the dbGAP: the application of data mining to identify biological mechanisms. Mol Interv. 2011 Apr; 11(2):95-102. Pubmed Abstract

Malhowski AJ, Hira H, Bashiruddin S, Warburton R, Goto J, Blanton, R, Kwiatkowski DJ, Finlay GA. Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin. Hum Mol Genet. 2011 Apr 1;20(7):1290-305. Epub 2011 Jan 6. Pubmed Abstract


Kimmelstiel C, Zhang P, Kapur NK, Weintraub A, Krishnamurthy B, Castaneda V, Covic L, Kuliopulos A. Bivalirudin is a dual inhibitor of thrombin and collagen-dependent platelet activation in patients undergoing percutaneous coronary intervention. Circ Cardiovasc Interv. 2011 Apr 1; 4(2):171-9. Pubmed Abstract


Heffernan KS, Kuvin JT, Sarnak MJ, Perrone RD, Miskulin DC, Rudym D, Chandra P, Karas RH, Menon V. Peripheral augmentation index and vascular inflammation in autosomal dominant polycystic kidney disease. Nephrol Dial Transplant. 2011 Feb 3. Pubmed Abstract


Heffernan KS, Maron MS, Patvardhan EA, Karas RH, Kuvin JT; Vascular Function Study Group. Relation of pulse pressure to blood pressure response to exercise in patients with hypertrophic cardiomyopathy. Am J Cardiol. 2011 Feb 15;107(4):600-3. Pubmed Abstract


Kitsios GD, Dahabreh IJ, Trikalinos TA, Schmid CH, Huggins GS, Kent DM. Heterogeneity of the phenotypic definition of coronary artery disease and its impact on genetic association studies. Circ Cardiovasc Genet. 2011 Feb 1;4(1):58-67. Pubmed Abstract


Chan MC, Weisman AS, Kang H, Nguyen PH, Hickman T, Mecker SV, Hill NS, Lagna G, Hata A. The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway. Mol Cell Biol. 2011 Feb;31(3):517-30. Pubmed Abstract


Kapur NK. Transforming growth factor-β: governing the transition from inflammation to fibrosis in heart failure with preserved left ventricular function. Circ Heart Fail. 2011 Jan 1; 4(1):5-7. Pubmed Abstract


Heffernan KS, Suryadevara R, Patvardhan EA, Mooney P, Karas RH, Kuvin JT. Effect of atenolol vs metoprolol succinate on vascular function in patients with hypertension. Clin Cardiol. 2011 Jan; 34(1):39-44. Pubmed Abstract


Davis-Dusenbery BN, Hata A. Smad-mediated miRNA processing: A critical role for a conserved RNA sequence. RNA Biol. 2011 Jan 1;8(1). Pubmed Abstract


Blanton RM, Nappi A, Kimmelstiel CD. Conversion of infarction-associated atrial fibrillation by restoration of atrial perfusion. Clin Cardiol. 2010 Dec; 33(12):E79-81. Pubmed Abstract


Jafri H, Alsheikh-Ali AA, Karas RH. Meta-analysis: statin therapy does not alter the association between low levels of high-density lipoprotein cholesterol and increased cardiovascular risk. Ann Intern Med. 2010 Dec 21;153(12):800-8. Pubmed Abstract


Kapur NK, Heffernan KS, Yunis AA, Parpos P, Kiernan MS, Sahasrabudhe NA, Kimmelstiel CD, Kass DA, Karas RH, Mendelsohn ME. Usefulness of soluble endoglin as a noninvasive measure of left ventricular filling pressure in heart failure. Am J Cardiol. 2010 Dec 15;106(12):1770-6. Pubmed Abstract


Saltzman AJ, Choi SW, Dabreo A, Baur WE, Weiss E, Nguyen K, Ishibashi F, Celestin FF, Karia DH, Pandian NG, Karas RH, Waxman S. Endothelial progenitor cells delivered into the pericardial space incorporate into areas of ischemic myocardium. Cardiovasc Revasc Med. 2010 Oct-Dec;11(4):241-8. Pubmed Abstract


Kapur NK, Heffernan KS, Yunis AA, Nguyen TA, Aronovitz MJ, Parpos P, Wilson S, Baker CK, Esposito ML, Shah A, Kimmelstiel CD, Weintraub A, Karas RH, Mendelsohn ME.  Elevated Soluble fms-Like Tyrosine Kinase-1 Levels in Acute Coronary Occlusion.  Arteriosclerosis Thrombosis, and Vascular Biology 2010; Nov. Pubmed Abstract


Higashimori M, Tatro JB, Moore KJ, Mendelsohn ME, Galper JB, Beasley D.  Role of toll-like receptor 4 in Intimal foam cell accumulation in apolipoprotein E-deficient mice.  Arteriosclerosis Thrombosis, and Vascular Biology 2010; Oct.  PubMed Abstract


Watson PA, Birdsey N, Huggins GS, Svensson EC, Heppe DB, Knaub LA.  Cardiac-specific overexpression of dominant-negative CREB leads to increased mortality and mitochondrial dysfunction in female mice.  American Journal of Physiology - Heart and Circulatory Physiology 2010; Oct.  PubMed Abstract


Felix-Getzik EM, Kuvin JT, Karas RH. Nonoptimal high-density lipoprotein cholesterol levels are highly prevalent in patients presenting with acute coronary syndromes and well-controlled low-density lipoprotein cholesterol
levels. J Clin Lipidol. 2010 Jul-Aug;4(4):265-71. Pubmed Abstract


Jaffe IZ, Newfell BG, Aronovitz M, Mohammad NN, McGraw AP, Perreault RE, Carmeliet P, Ehsan A, Mendelsohn ME.  Placental growth factor mediates aldosterone-dependent vascular injury in mice.  The Journal of Clinical Investigation 2010; 120(11):3891-3900.   PubMed Abstract