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Molecular Cardiology Research Institute

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2003 - 2011 Publications

Heffernan KS, Kuvin JT, Patel AR, Karas RH, Kapur NK. Endothelial function and soluble endoglin in smokers with heart failure.  Clin Cardiol. 2011 Dec;34(12):729-33. Epub 2011 Nov 28. Pubmed Abstract


Kapur NK, Paruchuri V, Korabathina R, Al-Mohammdi R, Mudd JO, Prutkin J, Esposito M, Shah A, Kiernan MS, Sech C, Pham DT, Konstam MA, Denofrio D. Effects of a percutaneous mechanical circulatory support device for medically refractory right ventricular failure. J Heart Lung Transplant. 2011 Dec;30(12):1360-7. Epub 2011 Aug 24. Pubmed Abstract


Heffernan KS, Patvardhan EA, Kapur NK, Karas RH, Kuvin JT. Peripheral augmentation index as a biomarker of vascular aging: an invasive hemodynamics approach. Eur J Appl Physiol. 2011 Dec 3. [Epub ahead of print] Pubmed Abstract


Davis-Dusenbery BN, Wu C, Hata A. Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2370-7. Pubmed Abstract


Wu C, So J, Davis-Dusenbery BN, Qi HH, Bloch DB, Shi Y, Lagna G, Hata A. Hypoxia Potentiates MicroRNA-Mediated Gene Silencing through Posttranslational Modification of Argonaute2. Mol Cell Biol. 2011 Dec; 31(23):4760-74. Pubmed Abstract


Georgescu SP, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM, Goruppi S. Decreased Metalloprotease 9 Induction, Cardiac Fibrosis and Higher Autophagy after Pressure Overload in Mice Lacking the Transcriptional Regulator p8. Am J Physiol Cell Physiol. 2011 Nov;301(5):C1046-56. Epub 2011 Jul 20. Pubmed Abstract


Kapur NK, Kociol RD.  Rise of the machines… and their mechanics. Catheter Cardiovasc Interv. 2011 Nov 15;78(6):962-3. (Commentary)


Gordon J, Hwang J, Carrier KJ, Jones CA, Kern QL, Moreno CS, Karas RH, Pallas DC. Protein Phosphatase 2A (PP2A) Binds Within the Oligomerization Domain of Striatin and Regulates the Phosphorylation and Activation of the Mammalian Ste20-Like Kinase Mst3. BMC Biochem. 2011 Oct 10;12(1):54. [Epub ahead of print]. Pubmed Abstract


Kiernan MS, Pham DT, Denofrio D, Kapur NK. Management of HeartWare left ventricular assist device thrombosis using intracavitary thrombolytics. J Thorac Cardiovasc Surg. 2011 Sep; 142(3):712-4. Pubmed Abstract


Peter I, Huggins GS, Ordovas JM, Haan M, Seddon JM. Evaluation of New and Established Age-Related Macular Degeneration Susceptibility Genes in the Women's Health Initiative Sight Exam (WHI-SE) Study. Am J Ophthalmol. 2011 Sep 8. [Epub ahead of print] Pubmed Abstract


Newfell BG, Iyer LK, Mohammad NN, McGraw AP, Ehsan A, Rosano G, Huang PL, Mendelsohn ME, Jaffe IZ. Aldosterone Regulates Vascular Gene Transcription via Oxidative Stress-Dependent and -Independent Pathways. Arterioscler Thromb Vasc Biol. 2011 Aug; 31(8):1871-80. Pubmed Abstract
Pugliese-Pires PN, Fortin JP, Arthur T, Latronico AC, Mendonca BB, Villares SM, Arnhold IJ, Kopin AS, Jorge AA. Novel inactivating mutations in the GH secretagogue receptor gene in patients with constitutional delay of growth and puberty. Eur J Endocrinol. 2011 Aug; 165(2):233-41. Pubmed Abstract


Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A. Down-regulation of Kruppel-like Factor-4 (KLF4) by MicroRNA-143/145 Is Critical for Modulation of Vascular Smooth Muscle Cell Phenotype by Transforming Growth Factor-{beta} and Bone Morphogenetic Protein 4. J Biol Chem. 2011 Aug 12; 286(32):28097-110. Pubmed Abstract

Kapur NK. A Clinical Commentary on the Articles "Strategies for Tissue Engineering Cardiac Constructs to Affect Functional Repair Following Myocardial Infarction" and "Stem Cell-Based Cardiac Tissue Engineering" : Repairing, Reprogramming, and Renewing: The Promise of Myocardial Cytotherapeutics. J Cardiovasc Transl Res. 2011 Aug 11. Pubmed Abstract

Pham CD, Sims HI, Archer TK, Schnitzler GR. Multiple Distinct Stimuli Increase Measured Nucleosome Occupancy around Human Promoters. PLoS One. 2011; 6(8):e23490. Pubmed Abstract

Kapur NK, Bian C, Lin E, Deming CB, Sperry JL, Hansen BS, Kakouros N, Rade JJ. Inhibition of transforming growth factor-β restores endothelial thromboresistance in vein grafts. J Vasc Surg. 2011 Jul 29. Pubmed Abstract

Patvardhan E, Heffernan KS, Ruan J, Hession M, Warner P, Karas RH, Kuvin JT. Augmentation index derived from peripheral arterial tonometry correlates with cardiovascular risk factors. Cardiol Res Pract. 2011; 253758. Pubmed Abstract

Bafford R, Sui XX, Park M, Miyahara T, Newfell BG, Jaffe IZ, Romero JR, Adler GK, Williams GH, Khalil RA, Conte MS. Mineralocorticoid receptor expression in human venous smooth muscle cells: a potential role for aldosterone signaling in vein graft arterialization. Am J Physiol Heart Circ Physiol. 2011 Jul; 301(1):H41-7. Pubmed Abstract

Smart-Halajko MC, Kelley-Hedgepeth A, Montefusco MC, Cooper JA, Kopin A, McCaffrey JM, Balasubramanyam A, Pownall HJ, Nathan DM, Peter I, Talmud PJ, Huggins GS; the Look AHEAD Study. ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial. BMC Med Genet. 2011 Jun 29; 12(1):89. Pubmed Abstract

McCurley A, Jaffe IZ. Mineralocorticoid receptors in vascular function and disease. Mol Cell Endocrinol. 2011 Jun 24. Pubmed Abstract

Korabathina R, Pham DT, Kapur NK. Subacute left ventricular rupture supported with a percutaneous left ventricular assist device. J Invasive Cardiol. 2011 Jun; 23(6):246-7. Pubmed Abstract


Tangri N, Alam A, Wooten EC, Huggins GS. Lack of association of Klotho gene variants with valvular and vascular calcification in Caucasians: a candidate gene study of the Framingham Offspring Cohort. Nephrol Dial Transplant. 2011 May 12. Pubmed Abstract

Wooten EC, Huggins GS. Mind the dbGAP: the application of data mining to identify biological mechanisms. Mol Interv. 2011 Apr; 11(2):95-102. Pubmed Abstract

Malhowski AJ, Hira H, Bashiruddin S, Warburton R, Goto J, Blanton, R, Kwiatkowski DJ, Finlay GA. Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin. Hum Mol Genet. 2011 Apr 1;20(7):1290-305. Epub 2011 Jan 6. Pubmed Abstract


Kimmelstiel C, Zhang P, Kapur NK, Weintraub A, Krishnamurthy B, Castaneda V, Covic L, Kuliopulos A. Bivalirudin is a dual inhibitor of thrombin and collagen-dependent platelet activation in patients undergoing percutaneous coronary intervention. Circ Cardiovasc Interv. 2011 Apr 1; 4(2):171-9. Pubmed Abstract


Heffernan KS, Kuvin JT, Sarnak MJ, Perrone RD, Miskulin DC, Rudym D, Chandra P, Karas RH, Menon V. Peripheral augmentation index and vascular inflammation in autosomal dominant polycystic kidney disease. Nephrol Dial Transplant. 2011 Feb 3. Pubmed Abstract


Heffernan KS, Maron MS, Patvardhan EA, Karas RH, Kuvin JT; Vascular Function Study Group. Relation of pulse pressure to blood pressure response to exercise in patients with hypertrophic cardiomyopathy. Am J Cardiol. 2011 Feb 15;107(4):600-3. Pubmed Abstract


Kitsios GD, Dahabreh IJ, Trikalinos TA, Schmid CH, Huggins GS, Kent DM. Heterogeneity of the phenotypic definition of coronary artery disease and its impact on genetic association studies. Circ Cardiovasc Genet. 2011 Feb 1;4(1):58-67. Pubmed Abstract


Chan MC, Weisman AS, Kang H, Nguyen PH, Hickman T, Mecker SV, Hill NS, Lagna G, Hata A. The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway. Mol Cell Biol. 2011 Feb;31(3):517-30. Pubmed Abstract


Kapur NK. Transforming growth factor-β: governing the transition from inflammation to fibrosis in heart failure with preserved left ventricular function. Circ Heart Fail. 2011 Jan 1; 4(1):5-7. Pubmed Abstract


Heffernan KS, Suryadevara R, Patvardhan EA, Mooney P, Karas RH, Kuvin JT. Effect of atenolol vs metoprolol succinate on vascular function in patients with hypertension. Clin Cardiol. 2011 Jan; 34(1):39-44. Pubmed Abstract


Davis-Dusenbery BN, Hata A. Smad-mediated miRNA processing: A critical role for a conserved RNA sequence. RNA Biol. 2011 Jan 1;8(1). Pubmed Abstract


Blanton RM, Nappi A, Kimmelstiel CD. Conversion of infarction-associated atrial fibrillation by restoration of atrial perfusion. Clin Cardiol. 2010 Dec; 33(12):E79-81. Pubmed Abstract


Jafri H, Alsheikh-Ali AA, Karas RH. Meta-analysis: statin therapy does not alter the association between low levels of high-density lipoprotein cholesterol and increased cardiovascular risk. Ann Intern Med. 2010 Dec 21;153(12):800-8. Pubmed Abstract


Kapur NK, Heffernan KS, Yunis AA, Parpos P, Kiernan MS, Sahasrabudhe NA, Kimmelstiel CD, Kass DA, Karas RH, Mendelsohn ME. Usefulness of soluble endoglin as a noninvasive measure of left ventricular filling pressure in heart failure. Am J Cardiol. 2010 Dec 15;106(12):1770-6. Pubmed Abstract


Saltzman AJ, Choi SW, Dabreo A, Baur WE, Weiss E, Nguyen K, Ishibashi F, Celestin FF, Karia DH, Pandian NG, Karas RH, Waxman S. Endothelial progenitor cells delivered into the pericardial space incorporate into areas of ischemic myocardium. Cardiovasc Revasc Med. 2010 Oct-Dec;11(4):241-8. Pubmed Abstract


Kapur NK, Heffernan KS, Yunis AA, Nguyen TA, Aronovitz MJ, Parpos P, Wilson S, Baker CK, Esposito ML, Shah A, Kimmelstiel CD, Weintraub A, Karas RH, Mendelsohn ME.  Elevated Soluble fms-Like Tyrosine Kinase-1 Levels in Acute Coronary Occlusion.  Arteriosclerosis Thrombosis, and Vascular Biology 2010; Nov. Pubmed Abstract


Higashimori M, Tatro JB, Moore KJ, Mendelsohn ME, Galper JB, Beasley D.  Role of toll-like receptor 4 in Intimal foam cell accumulation in apolipoprotein E-deficient mice.  Arteriosclerosis Thrombosis, and Vascular Biology 2011 Jan;31(1):50-7. Epub 2010 Oct 21. PubMed Abstract


Watson PA, Birdsey N, Huggins GS, Svensson EC, Heppe DB, Knaub LA.  Cardiac-specific overexpression of dominant-negative CREB leads to increased mortality and mitochondrial dysfunction in female mice.  American Journal of Physiology - Heart and Circulatory Physiology 2010; Oct.  PubMed Abstract


Felix-Getzik EM, Kuvin JT, Karas RH. Nonoptimal high-density lipoprotein cholesterol levels are highly prevalent in patients presenting with acute coronary syndromes and well-controlled low-density lipoprotein cholesterol
levels. J Clin Lipidol. 2010 Jul-Aug;4(4):265-71. Pubmed Abstract


Jaffe IZ, Newfell BG, Aronovitz M, Mohammad NN, McGraw AP, Perreault RE, Carmeliet P, Ehsan A, Mendelsohn ME.  Placental growth factor mediates aldosterone-dependent vascular injury in mice.  The Journal of Clinical Investigation 2010; 120(11):3891-3900.   PubMed Abstract


Goldstein C, Schroeder JC, Fortin JP, Goss JM, Schaus SE, Beinborn M, Kopin AS. Two Naturally Occurring Mutations in the Type 1 Melanin Concentrating Hormone Receptor Abolish Agonist-Induced Signaling. Journal of Pharmacology and Experimental Therapeutics 2010; 335(3):799-806. PubMed Abstract


Gurley SB, Griffiths RC, Mendelsohn ME, Karas RH, Coffman TM. Renal actions of RGS2 control blood pressure. Journal of the American Society of Nephrology 2010; 21(11):1847-1851. PubMed Abstract

Davis BN, Hata A. Mechanisms of control of microRNA biogenesis. The Journal of Biochemistry 2010; 148(4):381-392. PubMed Abstract


Chadee DN, Kyriakis JM. Activation of SAPK/JNKs In Vitro. Methods in Molecular Biology 2010; 661:59-73. PubMed Abstract


Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A. Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha. Molecular Cell 2010; 39(3):373-384. PubMed Abstract


Fortin JP, Ci L, Schroeder JC, Goldstein C, Montefusco MC, Peter I, Reis SE, Huggins GS, Beinborn M, Kopin AS. The Mu-Opioid Receptor Variant N190K is Unresponsive to Peptide Agonists Yet Can be Rescued by Small Molecule Drugs. Molecular Pharmacology 2010; 78(5):837-845. PubMed Abstract


Alsheikh-Ali AA, Karas RH. Balancing the intended and unintended effects of statins. British Medical Journal 2010; 340:c2240. PubMed Abstract


Brooks EL, Kuvin JT, Karas RH. Niacin's role in the statin era. Expert Opin Pharmacother 2010; 11(14):2291-2300. PubMed Abstract


Mendelsohn ME, Karas RH. Rapid progress for non-nuclear estrogen receptor signaling. Journal of Clinical Investigation 2010; 120(7):2277-2279. PubMed Abstract


Jafri H, Alsheikh-Ali AA, Karas RH. Baseline and on-treatment high-density lipoprotein cholesterol and the risk of cancer in randomized controlled trials of lipid-altering therapy. Journal of the American College of Cardiology 2010; 55(25):2846:2854. PubMed Abstract


Santen RJ, Allred DC, Ardoin SP, Archer DF, Boyd N, Braunstein GD, Burger HG, Colditz GA, Davis SR, Gambacciani M, Gower BA, Henderson VW, Jarjour WN, Karas RH, Kleerekoper M, Lobo RA, Manson JE, Marsden J, Martin KA, Martin L, Pinkerton JV, Rubinow DR, Teede H, Thiboutot DM, Utian WH. Postmenopausal Hormone Therapy: An Endocrine Society Scientific Statement. Journal of Clinical Endocrinology & Metabolism 2010; 97 (7 Suppl 1):s1-s66. PubMed Abstract


Heffernan KS, Patvardhan EA, Hession M, Ruan J, Karas RH, Kuvin JT. Elevated augmentation index derived from peripheral arterial tonometry is associated with abnormal ventricular-vascular coupling. Clinical Physiology and Functional Imaging 2010; 30(5):313-317. PubMed Abstract


Kong DK, Georgescu SP, Kyriakis JM, Goruppi S. Deficiency of transcriptional regulator p8 induces autophagy and causes impaired cardiac function. Autophagy 2010;6(5). PubMed Abstract


Denis GV, Nikolajczyk BS, Schnitzler GR. An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis. FEBS Letters 2010; 584(15):3260-3268. PubMed Abstract


Heffernan KS, Fahs CA, Ranadive SM, Patvardhan EA. L-arginine as a nutritional prophylaxis against vascular endothelial dysfunction with aging. Journal of Cardiovascular Pharmacology and Therapeutics 2010; 15(1):17-23. PubMed Abstract


Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K. Palmitoylation stabilizes unliganded rod opsin. Proceedings of the National Academy of Sciences, USA 2010; 107(18):8428-8433. PubMed Abstract


Montefusco MC, Merlo K, Bryan CD, Surks HK, Reis SE, Mendelsohn ME, Huggins GS. Little ROCK is a ROCK1 pseudogene expressed in human smooth muscle cells. BMC Genet 2010; 11:22. PubMed Abstract


Welzig CM, Park H-J, Karas RH, Naggar J, Estes M, Galper JB. Differential effects of statins (Pravastatin or Simvastatin) on ventricular ectopic complexes: G¡2, A Possible molecular marker for ventricular irritability. American Journal of Cardiology 2010; 105(8):1112-1117. PubMed Abstract


Heffernan KS, Karas RH, Patvardhan EA, Kuvin JT. Endothelium-dependent vasodilation is associated with exercise capacity in smokers and non-smokers. Vascular Medicine 2009; 15(2):119-125. PubMed Abstract


Miao L, Shi J, Wang CY, Zhu Y, Du X, Jiao H, Mo Z, Klocker H, Lee C, Zhang J. Estrogen receptor-related receptor {alpha} mediates up-regulation of aromatase expression by prostaglandin E2 in prostate stromal cells. Molecular Endocrinology 2010; 24(6):1175-1186. PubMed Abstract


Kilili GK, Kyriakis JM. Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity Via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation. The Journal of Biological Chemistry 2010; 285(20):15076-15087. PubMed Abstract


Kong DK, Georgescu SP, Cano C, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM, Goruppi S. Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function. Molecular Biology of the Cell 2010; 21(8):1335-1349. PubMed Abstract


Heffernan KS, Karas RH, Patvardhan EA, Jafri H, Kuvin JT. Peripheral arterial tonometry for risk stratification in men with coronary artery disease. Clinical Cardiology 2010; 33(2):94-98. PubMed Abstract


Beinborn M, Blum A, Hang L, Setiawan T, Schroeder JC, Stoyanoff K, Leung J, Weinstock JV. TGF-{beta} regulates T-cell neurokinin-1 receptor internalization and function. Proceedings of the National Academy of Sciences, USA 2010; 107(9):4293-4298. PubMed Abstract


Lavine JA, Raess PW, Davis DB, Rabaglia ME, Presley BK, Keller MP, Beinfeld MC, Kopin AS, Newgard CB, Attie AD. Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: A cautionary note. Molecular Endocrinology 2010; 24(2):464-467. PubMed Abstract


Patvardhan EA, Heffernan KS, Ruan JM, Soffler MI, Karas RH, Kuvin JT. Assessment of vascular endothelial function with peripheral arterial tonometry: Information at your fingertips? Cardiol in Rev 2010; 18(1):20-28. PubMed Abstract


Wooten EC, Iyer LK, Montefusco MC, Hedgepeth AK, Payne DD, Kapur NK, Housman DE, Mendelsohn ME, Huggins GS. Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve. PLoS One 2010; 5(1):e8830. PubMed Abstract


Heffernan KS, Napolitano CA, Maron MS, Patvardhan EA, Patel AR, Pandian NG, Karas RH, Kuvin JT. Peripheral vascular endothelial function in patients with hypertrophic cardiomyopathy. American Journal of Cardiology 2010; 105(1):112-115. PubMed Abstract


Heffernan KS, Karas RH, Mooney P, Patel A, Kuvin JT. Pulse wave amplitude is associated with brachial artery diameter: Implications for gender differences in microvascular function. Vascular Medicine 2009; 15(1):39-45. PubMed Abstract


Pang JJ, Gao F, Lem J, Bramblett DE, Paul DL, Wu SM. Direct rod input to cone BCs and direct cone input to rod BCs challenge the traditional view of mammalian BC circuitry. Proceedings of the National Academy of Sciences, USA 2009; 107(1):395-400. PubMed Abstract


Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A. Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. European Molecular Biology Organization Journal 2009; 29(3):559-573 PubMed Abstract


Pham CD, He X, Schnitzler GR. Divergent human remodeling complexes remove nucleosomes from strong positioning sequences. Nucleic Acids Research 2009; 38(2):400-413. PubMed Abstract


Hata A, Davis BN. Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus. Cytokine & Growth Factor Reviews 2009; 20(5-6):517-521. PubMed Abstract


Fortin JP, Schroeder JC, Zhu Y, Beinborn M, Kopin AS. Pharmacological characterization of human incretin receptor missense variants. Journal of Pharmacology and Experimental Therapeutics 2009 332(1):274-280 PubMed Abstract


Draper I, Tabaka ME, Jackson FR, Salomon RN, Kopin AS. The evolutionarily conserved RNA binding protein SMOOTH is essential for maintaining normal muscle function. Fly 2009; 3(4):1-11. PubMed Abstract


Danilova OV, Tai AK, Mele DA, Beinborn M, Leiter AB, Greenberg AS, Perfield JW 2nd, Defuria J, Singru PS, Lechan RM, Huber BT. Neurogenin 3-dpecific dipeptidyl peptidase-2 deficiency causes impaired glucose tolerance, insulin resistance, and visceral obesity. Endocrinology 2009; 150(12):5240-5248. PubMed Abstract


Mendelsohn ME. Estrogen actions in the cardiovascular system. Climacteric 2009; 12 Suppl 1:18-21. PubMed Abstract


Zhou J, Zhu Y, Cheng M, Dinesh D, Thorne T, Poh KK, Liu D, Botros C, Tang YL, Reisdorph N, Kishore R, Losordo DW, Qin G. Regulation of vascular contractility and blood pressure by the E2F2 transcription factor. Circulation 2009; 120(13):1213-1221. PubMed Abstract


Zhang Y, Naggar JC, Welzig CM, Beasley D, Moulton KS, Park HJ, Galper JB. Simvastatin inhibits angiotensin II-Induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice. possible role of ERK. Arteriosclerosis Thrombosis, and Vascular Biology 2009; 29(11):1764-1771. PubMed Abstract


Davis BD, Hata A. Regulation of MicroRNA Biogenesis: A miRiad of mechanisms. Cell Communication and Signaling 2009; 7:18. PubMed Abstract


Mohaupt MG, Karas RH, Babiychuk EB, Sanchez-Freire V, Monastyrskaya K, Iyer L, Hoppeler H, Breil F, Draeger A. Association between statin-associated myopathy and skeletal muscle damage. Canadian Medical Association Journal 2009; 181(1-2):E-11-E18. PubMed Abstract


Choi C, Fortin JP, McCarthy EV, Oksman L, Kopin AS, Nitabach MN. Cellular dissection of circadian peptide signals with genetically encoded membrane-tethered ligands. Current Biology 2009; 19(14):1167-1175. PubMed Abstract


Abd-El-Barr MM, Pennesi ME, Saszik SM, Barrow AJ, Lem J, Bramblett DE, Paul DL, Frishman LJ, Wu SM. Genetic dissection of rod and cone pathways in the dark-adapted mouse retina. Journal of Neurophysiology 2009; 102(3):1945-1955. PubMed Abstract


Vitale C, Mendelsohn ME, Rosano GM. Gender differences in the cardiovascular effect of sex hormones. Nature Reviews Cardiology 2009; 6(8):532-542. PubMed Abstract


Han SY, Beinborn M, Ahn JM. Facile synthesis of glucagon-like peptide-1 (GLP-1) mimetics. In: Advances in Experimental Medicine and Biology; Peptides for Youth; Susan Del Valle, Emanuel Escher and William D. Lubell (eds.), Springer New York 2009; 611:119-120. PubMed Abstract


Ahn JM, Han SY, Murage E, Beinborn M. Rational design of peptidomimetics for class B GPCRs: potent non-peptide GLP-1 receptor agonists. In: Advances in Experimental Medicine and Biology; Peptides for Youth; Susan Del Valle, Emanuel Escher and William D. Lubell (eds.), Springer New York 2009; 611:125-126. PubMed Abstract


Murage E, Beinborn M, Ahn JM. Seeking for alpha-helical propensity in a receptor-bound conformation of glucagon-like peptide-1. In: Advances in Experimental Medicine and Biology; Peptides for Youth; Susan Del Valle, Emanuel Escher and William D. Lubell (eds.), Springer New York 2009; 611:289-290. PubMed Abstract


Dean J, Plante J, Huggins GS, Snyder RO, Aikawa R. Role of CREB in recombinant adeno-associated virus-mediated transduction of heart muscle cells. Human Gene Therapy 2009; 20(9):1005-1012. PubMed Abstract


Patel AR, Hui H, Kuvin JT, Pandian NG, Karas RH. Modestly overweight women have vascular endothelial dysfunction. Clinical Cardiology 2009; 32(5):269-273. PubMed Abstract


Park HJ, Zhang Y, Du C, Welzig CM, Madias C, Aronovitz MJ, Georgescu SP, Naggar I, Wang B, Kim YB, Blaustein RO, Karas RH, Liao R, Mathews CE, Galper JB. Role of SREBP-1 in the Development of Parasympathetic Dysfunction in the Hearts of Type 1 Diabetic Akita Mice. Circulation Research 2009; 105(3):278-294. PubMed Abstract


Fortin JP, Zhu Y, Choi C, Beinborn M, Nitabach MN, Kopin AS. Membrane-tethered ligands are effective probes for exploring class B1 G protein-coupled receptor function. Proceedings of the National Academy of Sciences, USA 2009; 106(19):8049-8054 PubMed Abstract


Abraham J, Mudd JO, Kapur N, Klein K, Champion HC, Wittstein IS. Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists. Journal of the American College of Cardiology 2009; 53(15):1320-1325. PubMed Abstract


Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K. Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry 2009; 48(20):4294-4304. PubMed Abstract


Gupta A, Hou R, Liu L, Hiroyasu S, Hadix JA, Huggins GS, Sibinga NE. Daxx inhibits muscle differentiation by repressing E2A-mediated transcription. Journal of Cellular Biochemistry 2009; 107(3):438-447. PubMed Abstract


Aicher A, Heeschen C, Feil S, Hofmann F, Mendelsohn ME, Feil R, Dimmeler S. cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal vasculogenesis. PLoS One 2009; 4(3):e4879. PubMed Abstract


Schultz K, Murthy V, Tatro JB, Beasley D. Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by HIF-1{alpha}-dependent mechanisms. American Journal of Physiology - Lung Cellular and Molecular Physiology 2009; 296(6):L921-L927. PubMed Abstract


Neuman NA, Ma S, Schnitzler GR, Zhu Y, Lagna G, Hata A. The four-and-a-half lim domain protein 2 regulates vascular smooth muscle phenotype and vascular tone. Journal of Biological Chemistry 2009; 284(19):13202-13212. PubMed Abstract


Patten RD, Hall-Porter MR. Small animal models of heart failure: Development of novel therapies, past and present. Circulation: Heart Failure 2009; 2(2):138-144. PubMed Abstract


Alsheikh-AA, Karas RH. The relationship of statins to rhabdomyolysis, malignancy, and hepatic toxicity: evidence from clinical trials. Current Atherosclerosis Report 2009;11(2):100-104. PubMed Abstract


Heffernan KS, Karas RH, Kuvin JT, Jae SY, Vieira VJ, Fernhall B. Carotid artery stiffness, high-density lipoprotein cholesterol and inflammation in men with pre-hypertension. Journal of Human Hypertension 2009; 23(9):590-596. PubMed Abstract


Peter I, Hedgepeth AK, Huggins GS, Housman DE, Mendelsohn ME, Vita JA, Vasan RS, Levy D, Benjamin EJ, Mitchell GM. Association between arterial stiffness and variations in estrogen-related genes. Journal of Human Hypertension 2009; 23(10):636-644 PubMed Abstract


Wen XH, Shen L, Brush RS, Michaud N, Al-Ubaidi MR, Gurevich VV, Hamm HE, Lem J, Dibenedetto E, Anderson RE, Makino CL. Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors. Biophysical Journal 2009;96(3):939-950. PubMed Abstract

Patlolla V, Patten RD, Denofrio D, Konstam MA, Krishnamani R. The effect of ventricular assist devices on post-transplant mortality an analysis of the United network for organ sharing thoracic registry. Journal of American College of Cardiology 2009;53(3):264-271. PubMed Abstract


Sweet TB, Cox DH. Measuring the influence of the BKca β1 subunit on Ca²+ binding to the BKca channel. Journal of General Physiology 2009;133(2):139-150. PubMed Abstract


Wang Y, Zheng XR, Riddick N, Bryden M, Baur W, Zhang X, Surks HK. ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cell. Circulation Research 2009;104(4):531-540. PubMed Abstract


Takimoto E, Koitabashi N, Hsu S, Ketner EA, Zhang M, Nagayama T, Bedja D, Gabrielson KL, Blanton R, Siderovski DP, Mendelsohn ME, Kass DA. Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. Journal of Clinical Investigation 2009;119(2):408-420. PubMed Abstract


Kelley-Hedgepeth A, Peter I, Montefusco MC, Levy D, Benjamin EJ, Vasan RS, Mendelsohn ME, Housman D, Huggins GS, Mitchell GF. The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort. Journal of Hypertension 2009;27(1):55-60. PubMed Abstract


Caprio M, Mammi C, Jaffe IZ, Zennaro MC, Aversa A, Mendelsohn ME, Fabbri A, Rosano G. The mineralocorticoid receptor in endothelial physiology and disease: Novel concepts in the understanding of erectile dysfuction. Current Pharmaceutica Design 2008;14(35):3749-3757. PubMed Abstract


Kyriakis JM. Thinking outside the box about Ras. Journal of Biological Chemistry 2008; 284(17):10993-10994. PubMed Abstract


Davis BN, Hilyard AC, Nguyen PN, Lagna G, Hata A. Induction of microrna-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. Journal of Biological Chemistry 2008;284(6):3728-3738. PubMed Abstract


Donaldson C, Eder S, Baker C, Aronovitz MJ, Weiss AD, Hall-Porter M, Wang F, Ackerman A, Karas RH, Molkentin JD, Patten RD. Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation. Circulation Research 2008;104(2):265-275. PubMed Abstract


Brieke A, Krishnamani R, Rocha MJ, Li W, Patten RD, Konstam MA, Patel AR, Udelson JE, Denofrio D. Influence of donor cocaine use on outcome after cardiac transplantation: Analysis of the united network for organ sharing thoracic registry. Journal of Heart and Lung Transplantation 2008;27(12):1350-1352. PubMed Abstract


Meng H, Krishnaji ST, Beinborn M, Kumar K. Influence of Selective Fluorination on the Biological Activity and Proteolytic Stability of Glucagon-like Peptide-1. Journal of Medicinal Chemistry 2008;51(22):7303-7307. PubMed Abstract


Murage EN, Beinborn M, Ahn JM. Search for alpha-helical propensity in the receptor-bound conformation of glucagon-like peptide-1. Bioorganic & Medicinal Chemistry 2008;16(23):10106-10112. PubMed Abstract


Lavine JA, Raess PW, Davis DB, Rabaglia ME, Presley BK, Keller MP, Beinfeld MC, Kopin AS, Newgard CB, Attie AD. Overexpression of pre-pro-cholecystokinin stimulates β-cell proliferation in mouse and human islets with retention of islet function. Molecular Endocrinology 2008;22(12):2716-2728. PubMed Abstract


Sweet TB, Cox DH. Measurements of the BKCa channel's high-affinity Ca2+ binding constants: effects of membrane voltage. The Journal of General Physiology 2008;132(5):491-505. PubMed Abstract


Tsutsumi S, Zhang X, Takata K, Takahashi K, Karas RH, Kurachi H, Mendelsohn ME. Differential regulation of the inducible nitric oxide synthase gene by estrogen receptors 1 and 2. Journal of Endocrinology 2008;199(2):267-273. PubMed Abstract


Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS. Deletion of GSK-3β in Mice Leads to Hypertrophic Cardiomyopathy Secondary to Cardiomyoblast Hyperproliferation. Journal of Clinical Investigation 2008;118(11):3609-3618. PubMed Abstract


Sharma AK, Zhou GP, Kupferman J, Surks HK, Christensen EN, Chou JJ, Mendelsohn ME, Rigby AC. Probing the interaction between the coiled-coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C-terminus of the myosin binding subunit of the myosin light chain phosphatase. Journal of Biological Chemistry 2008;283(47):32860-32869. PubMed Abstract


Schnoes KK, Jaffe IZ, Iyer L, Dabreo A, Aronovitz M, Newfell B, Hansen U, Rosano G, Mendelsohn ME. Rapid recruitment of temporally distinct vascular gene sets by estrogen. Molecular Endocrinol 2008;22(11):2544-2556. PubMed Abstract


Anderson DS, Blaustein RO. Preventing voltage-dependent gating of anthrax toxin channels using engineered disulfides. The Journal General Physiology 2008;132(3):351-360. PubMed Abstract


Utian WH, Archer DF, Bachmann GA, Gallagher C, Grodstein F, Heiman JR, Henderson VW, Hodis HN, Karas RH, Lobo RA, Manson JE, Reid RL, Schmidt PJ, Stuenkel CA. Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause Society. Menopause 2008;15(4 Pt 1):584-602. PubMed Abstract


Alsheikh-AA, Trikalinos T, Kent DM, Karas RH. Statins, low-density lipoprotein cholesterol and risk of cancer. Journal of the American College of Cardiology 2008;52(14):1141-1147. PubMed Abstract


Fernández AB, Karas RH, Alsheikh-Ali AA, Thompson PD. Statins and interstitial lung disease: A systematic review of the literature and of FDA adverse event reports. Chest 2008;134(4):824-830. PubMed Abstract


Rouf R, Greytak S, Wooten EC, Wu J, Boltax J, Picard M, Svensson EC, Dillmann WH, Patten RD, Huggins GS. Increased FOG-2 in failing myocardium disrupts thyroid hormone-dependent SERCA2 gene transcription. Circulation Research 2008;103(5):493-501. PubMed Abstract


Nogueira E, Fidalgo M, Molnar A, Kyriakis J, Force T, Zalvide J, Pombo CM. SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and induces apoptotic cell death. The Journal of Biological Chemistry 2008;283(23):16248-16258. PubMed Abstract


Davis BN, Hilyard AC, Lagna G, Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 2008;454(7200):56-61. PubMed Abstract


Ballantyne CM, Davidson MH, McKenney JM, Keller LH, Bajorunas DR, Karas RH. Comparison of the safety and efficacy of a combination tablet of niacin extended release and simvastatin vs simvastatin monotherapy in patients with increased non-HDL Cholesterol (from the SEACOAST I Study). American Journal of Cardiology 2008;101(10):1426-1436. PubMed Abstract


Caprio M, Newfell BG, la Sala A, Baur W, Fabbri A, Rosano G, Mendelsohn ME, Jaffe IZ. Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion. Circulation Research 2008;102(11):1359-1367. PubMed Abstract


Peter I, Kelley-Hedgepeth A, Fox CS, Cupples LA, Huggins GS, Housman DE, Karas RH, Mendelsohn ME, Levy D, Murabito JM. Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels. The Journal of Clinical Endocrinology & Metabolism 2008;93(7):2779-2785. PubMed Abstract


Michael S, Surks HK, Wang Y, Zhu Y, Blanton R, Jamnongit M, Aronovitz M, Baur W, Ohtani K, Wilkerson MK, Bonev AD, Nelson MT, Karas RH, Mendelsohn ME. High blood pressure arising from a defect in vascular function. Proceedings of the National Academy of Sciences, USA 2008;105(18):6702-6707. PubMed Abstract


Alsheikh-AA, Karas RH. The safety of niacin in the US Food and Drug Administration adverse event reporting database. American Journal of Cardiology 2008;101(8):S9-S13.


Wong JY, Huggins GS, Debidda M, Munshi NC, De Vivo I. Dichloroacetate induces apoptosis in endometrial cancer cells. Gynecologic Oncology 2008;109(3):394-402. PubMed Abstract


Karas RH, Kashyap M, Knopp R, Keller L, Bajorunas DR, Davidson M. Long-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: The OCEANS Study. American Journal of Cardiovascular Drugs 2008;8(2):69-81. PubMed Abstract


Kelley-Hedgepeth A, Peter I, Kip KE, Montefusco MC, Kogan S, Cox D, Ordovas JM, Levy D, Reis SE, Mendelsohn ME, Housman D, Huggins GS. The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with β-blockade. Journal of Human Hypertension 2008;22(7):512-515. PubMed Abstract


Patten RD, Pourati I, Aronovitz MJ, Alsheikh-Ali A, Eder S, Force T, Mendelsohn ME, Karas RH. 17 β-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload. Journal of Cardiac Failure 2008;14(3):245-253. PubMed Abstract


Ballantyne CM, Davidson MH, McKenney JM, Keller LH, Bajorunas DR, Karas RH. Comparison of the efficacy and safety of a combination tablet of niacin extended-release and simvastatin with simvastatin 80 mg monotherapy: The SEACOAST II (high-dose) study. Journal of Clinical Lipidology 2008;2(2):79-80.


Stanic D, Paratcha G, Ledda F, Herzog H, Kopin AS, Hökfelt T. Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain. Proceedings of the National Academy of Sciences 2008;105(9):3610-3615. PubMed Abstract


Suryadevara RS, Karas RH, Kuvin JT. Use of extended-release niacin in clinical practice. Future Lipidology 2008;3(1):9-16. Abstract


Lem J, Rwayitare K. Transgenic strategies for the analysis of photoreceptor function. In: Signal Transduction in the Retina. S. Fliesler and O. Kisselev, 2008;Chapter 7:145-161.


Al-Fulaij MA, Ren Y, Beinborn M, Kopin AS. Pharmacological Analysis of Human D1 and D2 Dopamine Receptor Missense Variants. Journal of Molecular Neuroscience 2008;34(3):211-223. PubMed Abstract


Alsheikh-Ali AA, Karas RH. Reply. Journal of the American College of Cardiology 2008;51(1):92.

Park HJ, Georgescu SP, Du C, Madias C, Aronovitz MJ, Welzig CM, Wang B, Begley U, Zhang Y, Blaustein RO, Patten RD, Karas RH, Van Tol HH, Osborne TF, Shimano H, Liao R, Link MS, Galper JB. Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP. Journal of Clinical Investigation 2008;118(1):259-271. PubMed Abstract


Brill E, Malanson KM, Radu RA, Boukharov, NV, Wang Z, Chung H-Y, Lloyd MB, Bok D, Travis GH, Obin M, Lem J. A novel form of transducin-dependent retinal degeneration: Accelerated retinal degeneration in the absence of rod transducin. Investigative Ophthalmology & Visual Science 2007;48(12):5445-5453. PubMed Abstract


Patten RD. Models of gender differences in cardiovascular disease. Drug Discovery Today: Disease Models 2007;4(4):227-232.


Holoshitz N, Alsheikh-Ali AA, Karas RH. Relative safety of gemfibrozil and fenofibrate in the absence of concomitant cerivastatin use. American Journal of Cardiology 2007;101(1):95-97. PubMed Abstract

Surks HK. cGMP-dependent protein Kinase I and smooth muscle relaxation: A tale of two isoforms. Circulation Research 2007;101(11):1078-1080. PubMed Abstract


Alsheikh-Ali AA, Lin JL, Abourjaily P, Ahearn D, Kuvin JT, Karas RH. Prevalence of low high-density lipoprotein cholesterol in patients with documented coronary heart disease or risk equivalent and controlled low-density lipoprotein cholesterol. American Journal of Cardiology 2007;100(10):1499-1501. PubMed Abstract


Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A. Control of phenotypic plasticity of smooth muscle cells by BMP signaling through the myocardin-related transcription factors. The Journal of Biological Chemistry 2007;282(51):37244-37255. PubMed Abstract


Clarkson TB, Karas RH. Do the cardiovascular disease risks and benefits of oral versus transdermal estrogen therapy differ between perimenopausal and postmenopausal women? Menopause 2007;14(6):963-967. PubMed Abstract


Kim HJ, Lim HH, Rho SH, Bao L, Lee JH, Cox DH, Kim DH, Park CS. Modulation of the Conductance-Voltage Relationship of the BKCa Channel by Mutations at the Putative Flexible Interface Between Two RCK Domains. Biophysical Journal 2007;94(2):446-456. PubMed Abstract


Blaustein RO. On the Impossibility of Nonzero Reversal Potentials of Passive Pores Separating Symmetric Solutions: Comment on Haemophilus influenzae Outer Membrane Protein P5 Is Associated with Inorganic Polyphosphate and Polyhydroxybutyrate. Biophysical Journal 2007;93(8):2978. PubMed Abstract


Sanyal S, Karas RH, Kuvin JT. Present-day uses of niacin: effects on lipid and non-lipid parameters. Expert Opinion on Pharmacotherapy 2007;8(11):1711-1717. PubMed Abstract


Riddick N, Ohtani K, Surks HK. Targeting by myosin phosphatase-RhoA interacting protein mediates RhoA/ROCK regulation of myosin phosphatase. Journal of Cellular Biochemistry 2007;103(4):1158-1170. PubMed Abstract


Alsheikh-Ali AA, Maddukuri PV, Han H, Karas RH. Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials. Journal of the American College of Cardiology 2007;50(5):409-418. PubMed Abstract


Huggins GS, Lepore JJ, Greytak S, Patten RD, McNamee R, Aronovitz MJ, Wang P, Reed GL. The CREB leucine zipper regulates CREB phosphorylation, cardiomyopathy, and lethality in a transgenic model of heart failure. American Journal of Physiology - Heart and Circulatory Physiology 2007;293(3):H1877-H1882. PubMed Abstract


Liu G, Fortin JP, Beinborn M, Kopin AS. Four Missense Mutations in the Ghrelin Receptor Result in Distinct Pharmacological Abnormalities. Journal Pharmacology Experimental Therapeutics 2007;322(3):1036-1043. PubMed Abstract


Zhong J, Kyriakis JM. Dissection of a signaling pathway by which pathogen-associated molecular patterns (PAMPs) recruit the JNK and p38 MAPKs and trigger cytokine release. Journal of Biological Chemistry 2007;282(33):24246-24254. PubMed Abstract


Chan MC, Nguyen PH, Davis BN, Ohoka N, Hayashi H, Du K, Lagna G, Hata A. A novel regulatory mechanism of the Bone Morphogenetic Protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor. Molecular and Cellular Biology 2007;27(16):5776-5789. PubMed Abstract


Kutcher ME, Kolyada AY, Surks HK, Herman IM. Pericyte Rho GTPase mediates both pericyte contractile phenotype and capillary endothelial growth state. American Journal of Pathology 2007;171(2):693-701. PubMed Abstract


Mendelsohn ME, Karas RH. HRT and the Young at Heart. New England Journal of Medicine 2007;356(25):2639-2641.


Pullat RC, Gadarla MR, Karas RH, Thompson PD. Tendon rupture associated with simvastatin/ezetimibe therapy. American Journal of Cardiology 2007;100(1):152-153. PubMed Abstract


Rosenzweig DH, Nair KS, Wei J, Wang Q, Garwin G, Saari JC, Chen CK, Smrcka AV, Swaroop A, Lem J, Hurley JB, Slepak VZ. Subunit Dissociation and Diffusion Determine the Subcellular Localization of Rod and Cone Transducins. The Journal of Neuroscience 2007;27(20):5484-5494. PubMed Abstract


Peter I, Huggins GS, Shearman AM, Pollak A, Schmid CH, Cupples, Demissie S, Patten RD, Karas RH, Housman DE, Mendelsohn ME, Vasan RS, Benjamin EJ. Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-α gene. Hypertension 2007;49(5):1000-1006. PubMed Abstract


Bi S, Chen J, Behles RR, Hyun J, Kopin A, Moran TH. Differential body weight and feeding responses to high fat diet in rats and mice lacking cholecystokinin 1 receptors. AJP-Regulatory, Integrative and Comparative Physiology 2007;293(1):R55-R63. PubMed Abstract


Utian WH, Archer DF, Bachmann GA, Gallagher JC, Grodstein F, Heiman, JR, Henderson VW, Hodis HN, Karas RH, Lobo RA, Manson JE, Reid RL, Schmidt PJ, Stuenkel CA. Estrogen and progestogen use in peri- and postmenopausal women: March 2007 position statement of the North American Menopause Society. Menopause: Journal of the North American Menopause Society 2007;14(2):168-182.


Matthan NR, Jalbert SM, Ausman LM, Kuvin JT, Karas RH, Lichtenstein AH. Effect of soy protein from differently processed products on cardiovascular disease risk factors and vascular endothelial function in hypercholesterolemic subjects. The American Journal of Clinical Nutrition 2007;85(4):960-966. PubMed Abstract


Li HJ, Haque ZK, Chen A, Mendelsohn ME. RIF-1, a novel nuclear receptor corepressor that associates with the nuclear matrix. Journal of Cellular Biochemistry 2007;102(4):1021-1035. PubMed Abstract


Al-Fulaij MA, Ren Y, Beinborn M, Kopin A. Identification of Amino Acid Determinants of Dopamine 2 Receptor Synthetic Agonist Function. The Journal of pharmacology and experimental therapeutics, 2007;321(1):298-307. PubMed Abstract


Jaffe IZ, Tintut Y, Newfell BG, Demer LL, Mendelsohn ME. Mineralcorticoid Receptor Activation Promotes Vascular Cell Calcification. Ateriosclerosis, Thrombosis and Vascular Biology 2007;27(4):799-805. PubMed Abstract


O’Lone R, Knorr K, Jaffe IZ, Schaffer M, Martini P, Karas RH, Bienkowska J, Mendelsohn ME, Hansen U. Estrogen Receptors and β Mediate Distinct Pathways of Vascular Gene Expression, Including Genes Involved in Mitochondrial Electron Transport and Generation of Reactive Oxygen Species. Molecular Endocrinol 2007;21(6):1281-1296. PubMed Abstract


Rajala A, Anderson RE, Ma JX, Lem J, Al-Ubaidi MR, Rajala RV. G protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor. Journal of Biological Chemistry 2007;282(13):9865-9873. PubMed Abstract


Li J, Haque Z, Lu Q, Li L, Karas RH, Mendelsohn ME. Steroid receptor coactivator-3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation. Proceedings of the National Academy of Sciences, USA 2007;104(10):4065-4070. PubMed Abstract


Schultz K, Murthy V, Tatro JB, Beasley D. Endogenous Interleukin -1 promotes a proliferative and proinflammatory phenotype in human vascular smooth muscle cells. American Journal of Physiology - Heart and Circulatory Physiology, 2007;292(6):H2927-H2934. PubMed Abstract


Patten RD. Cellular, molecular, and structural changes during cardiac remodeling: In. Hosenpud JD and Greenberg BH, Editors Congestive Heart Failure, 3rd Edition, 2007;Chapter 8:128-146.


Alsheikh-Ali AA, Karas RH. Safety of lovastatin/extended release niacin compared with lovastatin alone, atorvastatin alone, pravastatin alone, and simvastatin alone (from the United States Food and Drug Administration Adverse Event Reporting System). American Journal of Cardiology 2006;99(3):379-381. PubMed Abstract


Draper I, Kurshan P, McBride EW, Jackson FR, Kopin AS. Locomotor activity is regulated by D2-like receptors in Drosophila: An anatomic and functional analysis. Developmental Neurobiology 2007;67(3):378-393. PubMed Abstract


Kuvin JT, Mammen A, Mooney P, Alsheikh-Ali AA, Karas RH. Assessment of peripheral vascular endothelial function in the ambulatory setting. 2007;Vascular Medicine 12(1):13-16. PubMed Abstract


Pombo CM, Force T, Kyriakis J, Nogueira E, Fidalgo M, Zalvide J. The GCK II and III subfamilies of the STE20 group kinases. Frontiers in Bioscience 2007;12:850-859. PubMed Abstract


Kyriakis JM. The integration of signaling by multiprotein complexes containing Raf kinases. Biochemica et Biophysica Acta 2007;1773(8):1238-1247. PubMed Abstract


Bemelmans AP, Kostic C, Hornfeld D, Jaquet M, Crippa SV, Hauswirth WW, Lem J, Wang Z, Schorderet DE, Munier FL, Wenzel A, Arsenijevic Y. Lentiviral vectors containing a retinal pigment epithelium specific promoter for leber congenital amaurosis gene therapy. Lentiviral gene therapy for LCA. Advances in Experimental Medicine and Biology 2006;572:247-253. PubMed Abstract


Isacson CK, Lu Q, Karas RH, Cox DH. RACK1 is a BKCa-Channel Binding Protein. American Journal of Physiology - Cell Physiology, 2006;292(4):C1459-C1466. PubMed Abstract


Cox DH. BKCa-Channel Structure and Function. in: Biological Membrane Ion Channels, 2006;Chung, Shin-Ho; Andersen, Olaf S.; Krishnamurthy, Vikram (Eds.). Chapter 5:171-219.


Ambrose MS, Denofrio D, Kuvin JT, Pandian NG, Karas RH, Patel AR. Low levels of high-density lipoprotein cholesterol are associated with vascular remodeling in cardiac transplant recipients. Transplantation Proceedings 2006;38(9):3016-3020. PubMed Abstract


Srinivasan VJ, Ko TH, Wojtkowski M, Carvalho M, Clermont A, Bursell SE, Song QH, Lem J, Duker JS, Schuman JS, Fujimoto JG. Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography. Investigative Ophthalmology & Visual Science 2006;47(12):5522-5528. PubMed Abstract


Darman RB, Ivy AA, Ketty V, Blaustein RO. Constraints on voltage sensor movement in the Shaker K+ channel. Journal of General Physiology 2006;128(6):687-699. PubMed Abstract


Soman P, Dave DM, Udelson JE, Han H, Ouda HZ, Patel AR, Karas RH, Kuvin JT. Vascular endothelial dysfunction is associated with reversible myocardial perfusion defects in the absence of obstructive coronary artery disease. Journal of Nuclear Cardiology 2006;13(6):756-760. PubMed Abstract


Goruppi S, Patten RD, Force T, Kyriakis JM. Helix-loop-helix protein p8: a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast MMP induction. Molecular and Cellular Biology, 2006;27(3):993-1006. PubMed Abstract


Park HJ, Zhang Y, Georgescu SP, Johnson KL, Kong D, Galper JB. Human umbilical vein endothelial cells and human dermal microvascular endothelial cells offer new insights into the relationship between lipid metabolism and angiogenesis. Stem Cell Reviews 2006;2(2):93-102. PubMed Abstract


Lagna G, Nguyen PH, Ni W, Hata A. BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells. American Journal Physiol - Lung Cellular and Molecular Physiology 2006;291(5):L1059-L1067. PubMed Abstract


Alsheikh-Ali AA, Lin JL, Abourjaily P, Ahearn D, Kuvin JT, Karas RH. Extent to which accepted serum lipid goals are achieved in a contemporary general medical population with coronary heart disease risk equivalents. American Journal of Cardiology 2006;98(9):1231-1233. PubMed Abstract


Shevtsov SP, Haq S, Force T. Activation of β-catenin signaling pathways by classical G-protein-coupled receptors: Mechanisms and consequences in cycling and non-cycling cells. Cell Cycle 2006;5(20):2295-2300. PubMed Abstract


Bemelmans AP, Kostic C, Crippa SV, Hauswirth WW, Lem J, Munier FL, Seeliger MW, Wenzel A, Arsenijevic Y. Lentiviral gene transfer of Rpe65 rescues survival and function of cones in a mouse model of leber congenital amaurosis. PLoS Pathogens 2006;3(10):1892-1903. PubMed Abstract


Alsheikh-Ali A, Husam OZ, Padian N, Karas RH, Kuvin JT. Evaluation of peripheral vascular endothelial fuction with a portable ultrasound device. Echocardiology 2006;23(8):623-626. PubMed Abstract


Kuvin JT, Dave DM, Sliney KA, Mooney P, Patel AR, Kimmelstiel CD, Karas RH. Effects of extended-release niacin on lipoprotein particle size, distribution, and inflammatory markers in patients with coronary artery disease. American Journal of Cardiology 2006;98(6):743-745. PubMed Abstract


Kerkela R, Force T. p38 mitogen-activated protein kinase: a future target for heart failure therapy? Journal of the American College of Cardiology 2006;48(3):556-558. PubMed Abstract


Turgeon JL, Carr MC, Maki PM, Mendelsohn ME, Wise PM. Complex actions of sex steroids in adipose tissue, the cardiovascular system, and brain: Insights from basic science and clinical studies. Endocrine Reviews 2006;27(6):575-605. PubMed Abstract


Kerkela R, Grazette L, Yacobi R, Iliescu C, Patten R, Beahm C, Walters B, Shevtsov S, Pesant S, Clubb FJ, Rosenzweig A, Salomon RN, Van Etten RA, Alroy J, Durand JB, Force T. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nature Medicine 2006;12(8):908-916. PubMed Abstract


Park HJ, Ward SM, Desgrosellier JS, Georgescu SP, Papageorge AG, Zhuang X, Barnett JV, Galper JB. Transforming growth factor β regulates the expression of the M2 muscarinic receptor in atrial myocytes via an effect on RhoA and p190RhoGAP. Journal of Biological Chemistry 2006;281(29):19995-20002. PubMed Abstract


Whited KL, Thao D, Lloyd KC, Kopin AS, Raybould HE. Targeted disruption of the murine CCK1 receptor gene reduces intestinal lipid-induced feedback inhibition of gastric function. American Journal Physiol Gastrointes Liver Physiol 2006;291(1):G156-G162. PubMed Abstract


Beinborn M. Class B GPCRs: A hidden agonist within? Molecular Pharmacology 2006;70(1):1-4. PubMed Abstract


Mukherjee RS, McBride EW, Beinborn M, Dunlap K, Kopin AS. Point mutations in either subunit of the GABAB receptor confer constitutive activity to the heterodimer. Molecular Pharmacology, 2006;70(4):1406-1413. PubMed Abstract


Xu D, Patten RD, Force T, Kyriakis JM. Gene 33/RALT is induced by hypoxia in cardiomyocytes, where it promotes cell death by suppressing phosphatidylinositol 3-kinase and extracellular signal-regulated kinase survival signaling. Molecular and Cellular Biology 2006;26(13):5043-5054. PubMed Abstract


Yang X, Murthy V, Schultz K, Tatro JB, Fitzgerald KA, Beasley D. Toll-like receptor 3 signaling evokes a proinflammatory and proliferative phenotype in human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol, 2006;291(5):H2334-H2343. PubMed Abstract


Moussaif M, Rubin WW, Kerov V, Reh R, Chen D, Lem J, Chen CK, Hurley JB, Burns ME, Artemyev NO. Phototransduction in a transgenic mouse model of Nougaret night blindness. The Journal of Neuroscience 2006;26(25):6863-6872. PubMed Abstract


Chen X, Shevtsov SP, Hsich E, Cui L, Haq S, Aronovitz M, Kerkela R, Molkentin JD, Liao R, Salomon RN, Patten R, Force T. The β-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy. Molecular and Cellular Biology 2006;26(12):4462-4473. PubMed Abstract


Ouyang P, Michos ED, Karas RH. Hormone replacement therapy and the cardiovascular system lessons learned and unanswered questions. Journal of the American College of Cardiology 2006;47(9):1741-1753. PubMed Abstract


Nikonov SS, Kholodenko R, Lem J, Pugh EN Jr. Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings. Journal of General Physiology 2006;127(4):359-374. PubMed Abstract


Kerkela R, Force T. Recent insights into cardiac hypertrophy and left ventricular remodeling. Current Heart Failure Reports 2006;3(1):14-18. PubMed Abstract


Tang D, Park HJ, Georgescu SP, Sebti SM, Hamilton AD, Galper JB. Simvastatin potentiates tumor necrosis factor α-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA. Life Science 2006;79(15):1484-1492. PubMed Abstract


Patten RD, Karas RH. Estrogen replacement and cardiomyocyte Protection. Trends in Cardiovascular Medicine 2006;16(3):69-75. PubMed Abstract


Shearman AM, Cooper JA, Kotwinski PJ, Miller GJ, Humphries SE, Ardlie KG, Jordan B, Irenze K, Lunetta KL, Schuit SCE, Uitterlinden AG, Pols HAP, Demissie S, Cupples LA, Mendelsohn ME, Levy D, Housman DE. Estrogen receptor α gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts. Circulation Research 2006;98(5):590-592. PubMed Abstract


Chadee DN, Xu D, Hung G, Andalibi A, Lim DJ, Luo Z, Gutmann DH, Kyriakis JM. Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. Proceedings of the National Academy of Sciences, 2006;USA 103(12):4463-4468. PubMed Abstract


Massie BM, Force T. The year in heart failure 2005. Journal of Cardiac Failure 2006;12(1):1-9. PubMed Abstract


Kuvin JT, Alsheikh-Ali AA, Karas RH. High-density lipoprotein cholesterol-raising strategies. Journal of Cardiovasc Pharmacol 2006;47(2):196-204. PubMed Abstract


Huggins GS, Wang JY, Hankinson SE, De Vivo I. GATA5 activation of the progesterone receptor gene promoter in breast cancer cells is influenced by the +331G/A polymorphism. Cancer Research 2006;66(3):1384-1390. PubMed Abstract


Schultz K, Fanburg, BL and Beasley D. Hypoxia and hypoxia-inducible factor-1α promote growth factor-induced proliferation in human vascular smooth muscle cells. American Journal of Physiology - Heart and Circulatory Physiology 2006;290(6):H2528-H2534. PubMed Abstract


Christensen EN, Mendelsohn ME. Cyclic GMP-dependent protein kinase Iª inhibits thrombin receptor-mediated calcium mobilization in vascular smooth muscle cells. Journal of Biological Chemistry 2006;281(13):8409-8416. PubMed Abstract


Liu E, Sinha S, Williams C, Cyrille M, Heller E, Snapper SB, Georgopoulos K, St-Arnaud R, Force T, Dedhar S, Gerszten RE. Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival. Molecular and Cellular Biology 2005;25(24):11145-11155. PubMed Abstract


Ku MC, Howard S, Ni W, Lagna G, Hata A. OAZ regulates bone morphogenetic protein signaling through Smad6 activation. Journal of Biological Chemistry 2005;281(8):5277-5287. PubMed Abstract


Peter I, Shearman AM, Zucker DR, Schmid CH, Demissie S, Cupples LA, Larson MG, Vasan RS, D'Agostino RB, Karas RH, Mendelsohn ME, Housman DE, Levy D. Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study. Journal of hypertension 2005;23(12):2193-2200. PubMed Abstract


Qui P, Ritchie R, Fu Z, Cao D, Cumming J, Miano JM, Wang DZ, Li HJ, Li L. Myocardin enhances Smad3-medicated transforming growth factors β¹, signaling in a CArG Box independent manner. Circulation Research 2005;97(10):983-991. PubMed Abstract


Patten RD, Konstam MA. Treatment of Remodeling: Inhibition of the Renin-Angiotensin-Aldosterone System. 2006;In Greenberg BH; Cardiac Remodeling; Taylor and Francis Group (Eds.). Chapter 18:325-348.


Masur K, Tibaduiza EC, Chen C, Ligon B, Beinborn M. Basal receptor activation by locally produced glucagon-like peptide-1 contributes to maintaining β-cell function. Molecular Endocrinology 2005;19(5):1373-1382. PubMed Abstract

Kuvin JT, Patel AR, Sliney KA, Pandian NG, Karas RH. Comparison of flow-mediated dilatation of the brachial artery in coronary patients with low-density lipoprotein cholesterol levels <80 mg/dl versus patients with levels 80 to 100 mg/dl. The American Journal of Cardiology 2005;95(1):93-95. PubMed Abstract

Mendelsohn ME. In hypertension, the kidneys are not always the heart of the matter. The Journal of Clinical Investigation 2005;115(4):840-844. PubMed Abstract

Kuvin JT, Sidhu M, Patel AR, Sliney KA, Pandian NG, Karas RH. Pulse pressure and peripheral arterial vasoreactivity. Journal of Human Hypertension 2005;19(6):501-502. PubMed Abstract

Bridgman P, Aronovitz MA, Kakkar R, Oliverio M, Coffman T, Rand W, Konstam MA, Mendelsohn ME, Patten RD. Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1ª receptor. American Journal of Physiology - Heart and Circulatory Physiology 2005;289(2):H586-H592. PubMed Abstract

Cox DH. The BKCa channel's Ca2+-binding sites, multiple sites, multiple ions. The Journal of General Physiology 2005;125(3):253-255. PubMed Abstract

Watanabe K, Beinborn M, Nagamatsu S, Ishida H, Takahashi S. Menetrier’s disease in a patient with helicobacter pylori infection is linked to elevated glucagons-like peptide-2 activity. Scandinavian Journal of Gastroenterology 2005;40(4):477-481. PubMed Abstract

Sharkey SW, Lesser JR, Zenovich AG, Maron MS, Lindberg J, Longe TF, Maron BJ. Acute and reversible cardiomyopathy provoked by stress in women from the United States. Circulation 2005;111(4):472-479. PubMed Abstract

Dorn GW, Force T. Protein kinase cascades in the regulation of cardiac hypertrophy. The Journal of Clinical Investigation 2005;115(3):527-537. PubMed Abstract

Yang X, Coriolan D, Murthy V, Schultz K, Golenbock DT, Beasley D. Proinflammatory phenotype of vascular smooth muscle cells: Role of efficient toll-like receptor 4 signaling. American Journal of Physiology - Heart and Circulatory Physiology 2005;289(3):H1068-H1076. PubMed Abstract

Alsheikh-Ali AA, Karas RH. Adverse events with concomitant amiodarone and statin therapy. Preventive Cardiology 2005;8(2):95-97. PubMed Abstract

Wang Z, Wen XH, Ablonczy Z, Crouch RK, Makino CL, Lem J. Enhanced shutoff of phototransduction in transgenic mice expressing palmitoylation- deficient rhodopsin. The Journal of Biological Chemistry 2005;280(26):24293-24300. PubMed Abstract

Patten RD, Denofrio D, El-Zaru M, Kakkar R, Saunders J, Celestin F, Warner K, Rastegar H, Khabbaz KR, Udelson JE, Konstam MA, Karas RH. Ventricular assist device therapy normalizes inducible nitric oxide synthase expression and reduces cardiomyocyte apoptosis in the failing human heart. Journal of the American College of Cardiology 2005;45(9):1419-1424. PubMed Abstract

Beinborn M, Worrall CI, McBride EM, Kopin AS. A human glucagon-like peptide-1 receptor polymorphism results in reduced agonist responsiveness. Regulatory Peptides 2005;130(1-2):1-6. PubMed Abstract

Mendelsohn ME, Karas RH. Molecular and cellular basis of cardiovascular gender differences. Science 2005;308(5728):1583-1587. PubMed Abstract

Georgescu SP, Li JH, Karas RH, Brown M, Mendelsohn ME. Modulator recognition factor 1 (MRF1), an AT-rich interaction domain family member, is a novel co-repressor for estrogen receptor α. Molecular Endocrinol 2005;19(10):2491-2501. PubMed Abstract

Alsheikh-Ali AA, Ambrose MS, Kuvin JT, Karas RH. The safety of rosuvastatin as used in common clinical practice: A postmarketing analysis. Circulation 2005;111(23):3051-3057. PubMed Abstract

Alsheikh-Ali AA, Kuvin JT, Karas, RH. High-density lipoprotein cholesterol in the cardiovascular equation: Does the “good” still count? Atherosclerosis 2005;180(2):217-223. PubMed Abstract

Huggins GS, O'Gara PT. Clinical presentation and diagnostic evaluation of ST-segment elevation myocardial infarction. In:. Atherothrombosis and Coronary Artery Disease, 2005;Fuster V, Topol EJ, Nabel,Chapter 50:849-866.

Hedrich O, Patten RD, DeNofrio D. Current treatment options for CHF Management: Focus on the renin-angiotensin-aldosterone system. Current Treatment Options in Cardiovascular Medicine 2005;7(1):3-13, 2005. PubMed Abstract

Shearman AM, Demissie S, Cupples LA, Peter I, Schmid CH, Mendelsohn ME, Ordovas J, Housman DE. Tobacco smoking, estrogen receptor α gene variation, and small low-density lipoprotein level. Human Molecular Genetics 2005;14(16):2405-2413. PubMed Abstract

Demissie S, Cupples LA, Shearman AM, Gruenthal KM, Peter I, Schmid CH, Karas RH Housman DE, Mendelsohn ME, Ordovas JM. Estrogen receptor-α variants are associated with lipoprotein size distribution and particle levels in women: The Framingham Heart Study. Atherosclerosis, 2005;185(1):210-218. PubMed Abstract

Ku M, Sokol SY, Wu J, Tussie-Luna MI, Roy AL, Hata A. Positive and negative regulation of the transforming growth factor β/activin target gene goosecoid by the TFII-I family of transcription factors. Molecular and Cellular Biology 2005;25(16):7144-7157. PubMed Abstract

Bao L, Cox DH. Gating and ionic currents reveal how the BKCa channel's Ca2+ sensitivity Is enhanced by its β1 subunit. The Journal General Physiology 2005;126(4):393-412. PubMed Abstract

Yang X, Coriolan D, Schultz K, Golenbock DT, Beasley D. Toll-like receptor 2 mediates persistent chemokine release by chlamydia pneumoniae-infected vascular smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology 2005;25(11):2308-2314. PubMed Abstract

Shearman AM, Cooper JA, Kotwinski PJ, Humphries SE, Mendelsohn ME, Housman DE, Miller GJ. Estrogen receptor ª gene variation and the risk of stroke. Stroke 2005;36(10):2281-2282. PubMed Abstract

Fox CS, Yang Q, Cupples LA, Guo CY, Atwood LD, Murabito JM, Levy D, Mendelsohn ME, Housman DE, Shearman AM. Sex-Specific Association Between Estrogen Receptor ª Gene Variation and Measures of Adiposity: the Framingham Heart Study. The Journal of Clinical Endocrinology and Metabolism 2005;90(11):6257-6262. PubMed Abstract

Kyriakis JM. Map kinase and growth factor pathways. In:. Endocrinology, 2005;LJ. DeGroot, JL Jameson (eds.), Elsevier, Philadelphia,Volum 1, Fifth Edition:237-275.

Maeda T, Lem J, Palczewski K, Haeseleer F. A critical role of CaBP4 in the cone synapse. Investigative Ophthalmology & Visual Science 2005;46(11):4320-4327. PubMed Abstract

Peter I, Shearman AM, Vasan RS, Zucker DR, Schmid CH, Demissie S, Cupples LA, Kuvin JT, Karas RH, Mendelsohn ME, Housman DE, Benjamin EJ. Association of estrogen receptor β gene polymorphisms with left ventricular mass and wall thickness in women. American Journal of Hypertension 2005;18(11):1388-1395. PubMed Abstract

Shearman AM, Demissie S, Cupples LA, Peter I, Schmid CH, Ordovas JM, Mendelsohn ME, Housman DE. Tobacco smoking, estrogen receptor α gene variation and small low-density lipoprotein level. Human Molecular Genetics 2005;14(16):2405-2413. PubMed Abstract

Patten RD, Karas RH. Cardiomyocyte apoptosis in the ischemic and failing hearts. Drug Discovery Today: Disease Mechanisms 2005;2(1):47-53.

Surks HK, Riddick N, Ohtani K. M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells. Journal of Biological Chemistry 2005;280(52):42543-4251. PubMed Abstract

D’eon TM, Souza SC, Aronovitz MA, Obin MS, Fried SK, Greenburg AS. Estrogen regulation of adiposity and fuel partitioning: Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways. Journal of Biological Chemistry 2005;280(43):35983-35991.

Huggins GS, Gewirte H. Chronic stable angina: Clinical presentation and diagnostic techniques. In: Atherothrombosis and Coronary Artery Disease, 2005;Fuster V, Topol EJ, Nabel,Chapter 88:1301-1312.

Xu D, Makkinje A, Kyriakis JM. Gene 33 is an endogenous inhibitor of Epidermal Growth Factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function. Journal of Biological Chemistry 2005;280(4):2924-2933. PubMed Abstract

Liu P, Konstam MA, Force T. Highlights of the 2004 scientific sessions of the Heart Failure Society of America, Toronto, ON, Canada Sept 12-15, 2004. Journal of the American College of Cardiology 2005;45 (4):617-625. PubMed Abstract

Jaffe IZ, Mendelsohn ME. Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells. Circulation Research 2005;96(6):643-650. PubMed Abstract

Skurk C, Maatz H, Rocnik E, Bialik A, Force T, Walsh K. Glycogen-synthase kinase3β/β-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells. Circulation Research 2005;96(3):308-318. PubMed Abstract

Patel AR, Kuvin JT, Sliney KA, Rand WM, Pandian NG, Karas RH. Peripheral vascular endothelial function correlates with exercise capacity in women. Clinical Cardiology 2005;28(9):433-436. PubMed Abstract

Patel AR, Kuvin JT, Sliney KA, Rand WM, Chiang JC, Udelson JE, Pandian NG, Karas RH. Gender-based differences in brachial artery flow-mediated vasodilation as an indicator of significant coronary artery disease. American Journal of Cardiology 2005;96(9):1223-1226. PubMed Abstract

Blow NS, Salomon RN, Garrity K, Reveillaud I, Kopin A, Jackson FR, Watnick PI. Vibrio cholerae infection of drosophilamelanogaster mimics the human disease cholera. PLoS Pathogens 2005;1(1):92-98. PubMed Abstract

Liu E, Sinha S, Williams C, Cyrille M, Heller E, Snapper SB, Georgopoulos K, St-Arnaud R, Force T, Dedhar S, Gerszten RE. Targeted deletion of integrin-linked kinase reveals a role in T cell chemotaxis and survival. Molecular and Cellular Biology 2005;25(24):11145-11155. PubMed Abstract

Shao Z, Bhattacharya K, Bhattacharya S, Hsich E, Park L, Walters B, Germann U, Wang YM, Mohanlal R, Kuida K, Namchuk M, Salituro F, Yao YM, Hou WM, Chen X, Aronowitz M, Tsichlis P, Force T, Kilter H. c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury In vitro and in vivo. Circulation Research 2005;98(1):111-118. PubMed Abstract

Mendelsohn ME. Viagra: Now mending hearts. Nature Medicine 2005;11(2):115-116. PubMed Abstract

Maron MS, Zenovich AG, Casey SA, Link MS, Udelson JE, Aeppli DM, Maron BJ. Significance and relationship between magnitude of left ventricular hypertrophy and heart failure symptoms in hypertrophic cardiomyopathy. American Journal of Cardiology 2005;95(11):1329-1333. PubMed Abstract


Seki K, Hata A. Indian hedgehog gene is a target of the bone morphogenetic protein signaling pathway. The Journal of Biological Chemistry 2004;279(18):18544-18549. PubMed Abstract

Wang DQ, Schmitz F, Kopin AS, Carey MC. Targeted disruption of the murine cholecystokinin-1 receptor promotes intestinal cholesterol absorption and susceptibility to cholesterol cholelithiasis. The Journal of Clinical Investigation 2004;114(4):521-528. PubMed Abstract

Finlay GA, York B, Karas RH, Fanburg BL, Zhang H, Kwiatkowski DJ, Noonan DJ. Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of PDGFR-β and ERK-1/2. The Journal of Biological Chemistry 2004;279(22):23114-23122. PubMed Abstract

Young CE, Karas RH, Kuvin JT. High-density lipoprotein cholesterol and coronary heart disease. Cardiology in Review 2004;12(2):107-119. PubMed Abstract

Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S. Early hematopoietic zinc finger protein (EHZF), the human homologue to mouse Evi3, is highly expressed in primitive human hematopoietic cells. Blood 2004;103(6):2062-2070. PubMed Abstract

Lem J, Fain GL. Constitutive opsin signaling: Night blindness or retinal degeneration? Trends in Molecular Medicine 2004;10(4):150-157. PubMed Abstract

Michael A, Haq S, Chen X, Hsich E, Cui L, Walters B, Shao Z, Bhattacharya K, Kilter H, Huggins G, Andreucci M, Periasamy M, Solomon RN, Liao R, Patten R, Molkentin JD, Force T. Glycogen synthase kinase-3β regulates normal post-natal cardiac growth, calcium homeostasis and diastolic function of the heart. The Journal of Biological Chemistry 2004;279(20):21383-21393. PubMed Abstract

Wang Y, El-Zaru MR, Surks HK, Mendelsohn ME. Formin homology domain protein FHOD1 is a cyclic GMP-dependent protein kinase 1α binding protein and substrate in vascular smooth muscle cells. The Journal of Biological Chemistry 2004;279(23):24420-24426. PubMed Abstract

Goruppi S, Kyriakis JM. The pro-hypertrophic bHLH protein p8 is degraded by the ubiquitin proteasome system in a protein kinase-B/Akt and glycogen synthase kinase-3-dependent manner, while endothelin induction of p8 mRNA and renal mesangial cell hypertrophy require NFAT4. The Journal of Biological Chemistry 2004;279(20):20950-20958. PubMed Abstract

Bao L, Kaldany C, Holmstrand EC, Cox DH. Mapping the BKCa channels "Ca2+ bowl": Side-chains essential for Ca2+ sensing. Journal of General Physiology 2004;123(5):475-489. PubMed Abstract

Bi S, Scott KA, Kopin AS, Moran TH. Differential roles for cholecystokinin-A receptors in energy balance in rats and mice. Endocrinology 2004;145(8):3873-3880. PubMed Abstract

Takabayashi T, Shimizu S, Clark BD, Beinborn M, Burke JF, Gelfand JA. Interleukin-1 upregulates anaphylatoxin receptors on mononuclear cells. Surgery 2004;135(5):544-554. PubMed Abstract

Danciger M, Lyon J, Worrill D, Hoffman S, Lem J, Reme CE, Wenzel A, Grimm C. New retinal light damage QTL in mice with the light-sensitive RPE65 LEU variant. Mammalian Genome 2004;15(4):277-283. PubMed Abstract

Alsheikh-Ali AA, Karas RH. Adverse events with concomitant use of simvastatin or atorvastatin and thiazolidinediones. American Journal of Cardiology 2004;93(11):1417-1418. PubMed Abstract

Giacobini P, Kopin AS, Beart PM, Mercer LD, Fasolo A, Wray S. Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons. Journal of Neuroscience 2004;24(20):4734-4748. PubMed Abstract

Grazette LP, Boecker W, Matsui T, Semigran M, Force TL, Hajjar RJ, Rosenzweig A. Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: Implications for herceptin-induced cardiomyopathy. Journal of the American College of Cardiology 2004;44(11):2231-2238. PubMed Abstract

Rindi G, Leiter AB, Kopin AS, Bordi C, Solcia E. The "normal" endocrine cell of the gut: Changing concepts and new evidences. Annals of the New York Academy of Sciences 2004;1014:1-12. PubMed Abstract

Karas RH. Current controversies regarding the cardiovascular effects of hormone therapy. Clinical Obstetrics & Gynecologyl 2004;47(2):489-499. PubMed Abstract

Chadee DN, Kyriakis JM. MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation. Nature Cell Biology 2004;6(8):770-776. PubMed Abstract

Patten RD, Soman P. Prevention and reversal of LV remodeling with neurohormonal inhibitors. Current Treatment Options in Cardiovascular Medicine 2004;6(4):313-325. PubMed Abstract

Endo A, Surks HK, Mochizuki S, Mochizuki N, Mendelsohn ME. Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase. The Journal of Biological Chemistry 2004;279(40):42055-42061. PubMed Abstract

Naftolin F, Taylor HS, Karas RH, Brinton E, Newman I, Clarkson TB, Mendelsohn M, Lobo RA, Udelson J, Nachtigall LE, Heward CB, Hecht H, Jaff MR, Harman SM. The Women’s Health Initiative (WHI) could not have detected cardioprotective effects of starting hormone therapy during the menopausal transition. Fertility and Sterility 2004;81(6):1498-1501. PubMed Abstract

Naash MI, Wu TH, Chakraborty D, Fliesler SJ, Ding XQ, Nour M, Peachey NS, Lem J, Qtaishat N, Al-Ubaidi MR, Ripps H. Retinal abnormalities associated with the G90D mutation in opsin. The Journal of Comparative Neurology 2004;478(2):149-163. PubMed Abstract

He W, Yasumatsu K, Varadarajan V, Yamada A, Lem J, Ninomyia Y, Margolskee RF, Damak S. Umami taste responses are mediated by α-transducin and α-gustducin. Journal of Neuroscience 2004;24(35):7674-7680. PubMed Abstract

Patten RD, Pourati I, Aronovitz MJ, Baur J, Celestin F, Chen X, Michael A, Haq S, Neudling S, Grohe C, Force T, Mendelsohn ME, Karas RH. 17β-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling. (SCOR) Circulation Research 2004;95(7):692-699. PubMed Abstract

Friedrich EB, Liu E, Sinha S, Cook S, Milstone DS, MacRae CA, Mariotti M, Kuhlencordt PJ, Force T, Rosenzweig A, St-Arnaud R, Dedhar S, Gerszten RE. Integrin-linked kinase regulates endothelial cell survival and vascular development. Molecular and Cellular Biology 2004;24(18):8134-8144. PubMed Abstract

Liu P, Konstam MA, Force T. Highlights of the 2003 scientific sessions of the Heart Failure Society of America. Journal of the American College of Cardiology 2004;43(6):1103-1109. PubMed Abstract

Zhong J, Kyriakis JM. Germinal center kinase is required for optimal JNK activation by TLR agonists and is regulated by the ubiquitin proteasome system and agonist-induced, TRAF6-dependent stabilization. Molecular and Cellular Biology 2004;24(20):9165-9175. PubMed Abstract

Alsheikh-Ali AA, Kuvin JT, Karas RH. Risk of adverse events with fibrates. American Journal of Cardiology 2004;94(7):935-938. PubMed Abstract

Chadee DN, Kyriakis JM. A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation. Cell Cycle 2004;3(10):1225-1226. PubMed Abstract

Noguchi T, Hunlich M, Camp PC, Begin KJ, El-Zaru M, Patten R, Leavitt BJ, Ittleman FP, Alpert NR, LeWinter MM, VanBuren P. Thin filament-based modulation of contractile performance in human heart failure. Circulation 2004;110(8):982-987. PubMed Abstract

Woodruff ML, Lem J, Fain GL. Early receptor current of wild-type and transducin knockout mice: Photosensitivity and light-induced Ca2+ release. The Journal of Physiology 2004;557(3):821-828. PubMed Abstract

Balk EM, Karas RH, Jordan HS, Kupelnick B, Chew P, Lau J. Effects of statins on vascular structure and function: A systematic review. American Journal of Medicine 2004;117(10):775-790. PubMed Abstract

Lu Q, Pallas DC, Surks HK, Baur WE, Mendelsohn ME, Karas RH. Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial no synthase by estrogen receptor α. Proceedings of the National Academy of Sciences, 2004;USA 101(49):17126-17131. PubMed Abstract

Beinborn M, Ren Y, Bläker M, Chen C, Kopin AS. Ligand function at constitutively active receptor mutants is affected by two distinct yet interacting mechanisms. Molecular Pharmacology 2004;65(3):753-760. PubMed Abstract

Blaustein BO, Miller C. Ion channels: Shake, rattle or roll? Nature 2004;427:499-500. PubMed Abstract

Mosca L, Appel LJ, Benjamin EJ, Berra K, Chandra-Strobos N, Fabunmi RP, Grady D, Haan CK, Hayes SN, Udelson J, Keenan NL, McBride P, Oparil S, Ouyang P, Oz MC, Mendelsohn ME, Pasternak RC, Pinn VW, Robertson RM, Schenck-Gustafsson K, Sila CA, Smith SC Jr, Sopko G, Taylor AL, Walsh BW, Wenger NK, Williams CL. Evidence-based guidelines for cardiovascular disease prevention in women. Circulation 2004;109:672-693; Arterioscler Thromb Vascular Biology 2004;24(3):e29-e50; Journal of the American College of Cardiology 2004;43(5):900-921. PubMed Abstract

Kyriakis JM, Liu H, Chadee DN. Activation of SAPKs/JNKs and p38s In vitro. Methods in Molecular Biology 2004;250:61-88. PubMed Abstract

Force T, Kuida K, Namchuk M, Parang K, Kyriakis JM. Inhibitors of protein kinase signaling pathways: Emerging therapies for cardiovascular disease. Circulation 2004;109(10):1196-1205. PubMed Abstract

Karas RH. Non-genomic Actions of Hormones. In. Principles of Sex-based Differences in Physiology, 2004;Virginia M. Miller, Meredith Hay,34:49-57.

Maron BJ, Dearani JA, Ommen SR, Maron MS, Schaff HV, Gersh BJ, Nishimura RA. The case for surgery in obstructive hypertrophic cardiomyopathy. Journal of the American College of Cardiology 2004;44(10):2044-2053. PubMed Abstract

Harman SM, Brinton EA, Clarkson T, Heward CB, Hecht HS, Karas RH, Judleson DR, Naftolin F. Is the WHI relevant to HRT started in the perimenopause? Endocrine 2004;24(3):195-202. PubMed Abstract

Macklis R, Mendelsohn ME, Mudge G. Manual of Introductory Clinical Medicine. In. Boston: Little, 2004;Brown & Co., Fourth Edition.


Lu Q, Surks HK, Ebling H, Baur WE, Brown D, Pallas DC, Karas, RH. Regulation of estrogen receptor α-mediated transcription by a directinteraction with protein phosphatase 2A. Journal of Biological Chemistry 2003;278(7):4639-4645. PubMed Abstract

Patel AR, Kuvin JT, DeNofrio D, Kinan D, Sliney KA, Eranki KP, Pandian NG, Udelson JE, Konstam MA, Karas RH. Peripheral vascular endothelial function correlates with exercise capacity in cardiac transplant recipients. The American Journal of Cardiology 2003;91(7):897-899. PubMed Abstract

Abourjaily HM, Alsheikh-Ali AA, Karas RH. Comparison of the frequency of adverse events in patients treated with atorvastatin or simvastatin. The American Journal of Cardiology 2003;91(8):999-1002. PubMed Abstract

Ren Y, Blaker M, Seshadri L, McBride EW, Beinborn M, Kopin AS. Conserved cholecystokinin receptor transmembrane domain IV amino acids confer peptide affinity. Journal of Molecular Neuroscience 2003;20:115-123. PubMed Abstract

Lee H-Y, Srinivas H, Xia D, Lu Y, Superty R, LaPushin R, Gomez-Manzano C, Gal AM, Walsh GL, Force T, Ueki K, Mills GB, Kurie JM. Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent pathways cooperate to maintain lung cancer cell survival. Journal of Biological Chemistry 2003;278(26):23630-23638. PubMed Abstract

Ramet ME, Ramet M, Lu Q, Nickerson M, Savolainen MJ, Malzone A, Karas RH. High-density lipoprotein increases the abundance of eNOS protein in human vascular endothelial cells by increasing its half-life. Journal of the American College of Cardiology 2003;41(12):2288-2297. PubMed Abstract

Patten RD, Aronovitz MJ, Einstein M, Lambert M, Pandian NG, Mendelsohn ME, Konstam MA. Effects of angiotensin II receptor blockade versus angiotensin-converting-enzyme inhibition on ventricular remodelling following myocardial infarction in the mouse. Clinical Science (Lond) 2003;104(2):109-118. PubMed Abstract

Haq S, Kilter H, Michael A, Tao J, O'Leary E, Sun XM, Walters B, Bhattacharya K, Chen X, Cui L, Andreucci M, Rosenzweig A, Guerrero JL, Patten R, Liao R, Molkentin J, Picard M, Bonventre JV, Force T. Deletion of Cytosolic phospholipase A(2) promotes striated muscle growth. Nature Medicine 2003;9(7):944-951. PubMed Abstract

Kuvin JT, Karas RH. Clinical utility of endothelial function testing: Ready for prime time? Circulation 2003;107(25):3243-3247. PubMed Abstract

Hattar S, Lucas RJ, Mrosovsky N, Thompson S, Douglas RH, Hankins MW, Lem J, Biel M, Hofmann F, Foster RG, Yau K-W. Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature 2003;424:76-81. PubMed Abstract

Takahashi S, Mendelsohn ME. Calmodulin-dependent and -independent activation of endothelial nitric-oxide synthase by heat shock protein 90. (SCOR) Journal of Biological Chemistry 2003;278(11):9339-9344. PubMed Abstract

Kopin AS, McBride EW, Chen C, Freidinger RM, Chen D, Zhao C-M, Beinborn M. Identification of a series of CCK-2 receptor nonpeptide agonists: Sensitivity to stereochemistry and a receptor point mutation. Proceedings of the National Academy of Sciences, USA 2003;100(9):5525-5530. PubMed Abstract

Mendez A, Lem J, Simon M, Chen J. Light-dependent translocation of arrestin in the absense of rhodopsin phosphorylation and transducin signaling. Journal Neurosci 2003;23(8):3124-3129. PubMed Abstract

Li L, Ouyang B, Choukroun G, Matyal R, Mascarenhas M, Jafari B, Bonventre JV, Force T, Quinn DA. Stretch-induced IL-8 depends on C-Jun NH2-Terminal and nuclear factor-κB-inducing kinases. American Journal Physiol - Lung Cellular and Molecular Physiology 2003;285(2):L464-L475. PubMed Abstract

Doran AC, Wan Y-P, Kopin AS, Beinborn M. Established theory of radiation-induced decay is not generalizable to bolton-hunter labeled peptides. Biochemical Pharmacology 2003;65:1515-1520. PubMed Abstract

Kuvin JT, Patel AR, Sliney KA, Pandian NG, Sheffy J, Schnall RP, Karas RH, Udelson JE. Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude. American Heart Journal 2003;146(1):168-174. PubMed Abstract

Kuvin JT, Karas RH. The effects of LDL reduction and HDL augmentation on physiologic and inflammatory markers. Current Opinion in Cardiology 2003;18(4):295-300. PubMed Abstract

Brill E, Patnala S, Lem J, Obin M. Bright light induces retinal degeneration by a transducin-independent mechanism. In. Advances in Experimental Medicine and Biology 2003;Vol. 533, Retinal Degenerations: Mechanisms and Experimental Therapy, LaVail MM, Hollyfield JG, Anderson RE (eds.), Plenum Publishers.533:213-219. PubMed Abstract

Karas RH, Clarkson TB. Considerations in interpreting the cardiovascular effects of hormone replacement therapy observed in the WHI: Timing is everything. Menopausal Medicine 2003;10:8-12.

Takahashi S, Mendelsohn ME. Synergistic activation of endothelial Nitric-oxide synthase (eNOS) by HSP90 and Akt: Calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-BOUND eNOS complex. (SCOR) Journal of Biological Chemistry 2003;278(33):30821-30827. PubMed Abstract

Makino CL, Wen X-H, Lem J. Piecing together the timetable for visual transduction with transgenic animals. Current Opinion in Neurobiology 2003;13(4):404-412. PubMed Abstract

Woodruff ML, Wang Z, Chung H, Redmond M, Fain G, Lem J. Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis. Nature Genetics 2003;35(2):158-164. PubMed Abstract

Xu D, Kyriakis JM. Phosphatidyl inositol-3’OH kinase-dependent activation of renal mesangial cell ki-ras and ERK by advanced glycation end products. Journal of Biological Chemistry 2003;278(41):39349-39355. PubMed Abstract

Kuvin JT, Patel AR, Sidhu M, Rand WM, Sliney KA, Pandian NG, Karas RH. Relation between high-density lipoprotein cholesterol and peripheral vasomotor function. American Journal of Cardiology 2003;92:275-279. PubMed Abstract

Andreucci M, Michael A, Kramers C, Park KM, Chen A, Matthaeus T, Alessandrini A, Haq S, Force T, Bonventre JV. Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1. Kidney International 2003;64(4):1189-1198. PubMed Abstract

Balk EM, Lau J, Goudas LC, Jordan HS, Kupelnick BA, Kim LU, Karas RH. Effects of statins on nonlipid serum markers associated with cardiovascular disease: A systematic review. The Annals of Internal Medicine 2003;139(8):670-682. PubMed Abstract

Seki K, Fujimori T, Savagner P, Hata A, Aikawa T, Ogata N, Nabeshima Y, Lee K. Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan. Journal of Biological Chemistry 2003;278(43):41862-41870. PubMed Abstract

Kienker PK, Jakes KS, Blaustein RO, Miller C, Finkelstein A. Sizing the protein translocation pathway of colicin Ia channels. The Journal of General Physiology 2003;22:161-176. PubMed Abstract

Bruna A, Nicolas M, Munoz A, Kyriakis JM, Caelles C. Glucocorticoid receptor-JKN interaction mediates inhibition of the JNK pathway by glucocorticoids. The EMBO Journal 2003;22(22):6035-6044. PubMed Abstract

Kyriakis JM. At the crossroads: AMP-activated kinase and the LKBI tumor suppressor link cell proliferation to metabolic regulation. Journal of Biology 2003;2(4):Article 26. PubMed Abstract

Roelen BA, Cohen OS, Raychowdhury MK, Chadee DN, Zhang Y, Kyriakis JM, Alessandrini AA, Lin HY. Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-β-induced nuclear accumulation. American Journal Physiology - Cell Physiology 2003;285(4):C823-C830. PubMed Abstract

Kuliopulos A, Covic L. Blocking receptors from the inside: Peducin-based intervention of PAR signaling and thrombosis. Life Sciences 2003;74:255-262. PubMed Abstract

Shearman AM, Cupples LA, Demissie S, Peter I, Schmid CH, Karas RH, Mendelsohn ME, Housman DE, Levy D. Association between estrogen receptor α gene variation and cardiovascular disease. (SCOR) The Journal of the American Medical Association 2003;290(17):2263-2270. PubMed Abstract

Ku M, Stewart S, Hata A. Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes. Biochemical and Biophysical Research Communications 2003;311(3):702-707. PubMed Abstract

Mendelsohn ME, Rosano GMC. Hormonal regulation of normal vascular tone in males. (SCOR) Circulation Research 2003;93(12):1142-1145. PubMed Abstract

Pourati I, Kimmelstiel C, Rand W, Karas RH. Statin use is associated with enhanced collteralization of severely diseased coronary arteries. American Heart Journal 2003;146(5):876-881. PubMed Abstract

Welzig CM, Shin D-G, Park H-J, Kim Y-J, Saul JP, Galper JB. Lipid lowering by pravastatin increases parasympathetic modulation of heart rate: Gαι2, a possible molecular marker for parasympathetic responsiveness. Circulation 2003;108(22):2743-2746. PubMed Abstract

Udelson JE, Patten RD, Konstam MA. New concepts in post-infarction ventricular remodeling. Reviews in Cardiovascular Medicine 2003;4(3):S3-S12. PubMed Abstract

Martemyanov KA, Lishko PV, Calero N, Keresztes G, Sokolov M, Strissel KJ, Leskov IB, Hopp JA, Kolesnikov AK, Chen CK, Lem J, Heller S, Burns ME, Arshavsky VY. The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. Journal Neurosci 2003;23(32):10175-10181. PubMed Abstract

Jacques SL, Kuliopulos A. Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage. Biochem Journal 2003;376:733-740. PubMed Abstract

Covic L, Jacques SL, Kuliopulos A. Inhibition of platelet thromboxane receptor function by a thrombin receptor-targeted pepducin. Nature Medicine 2003;9(12):1447-1448.

Seeley S, Covic L, Jacques SL, Sudmeier J, Baleja JD, Kuliopulos A. Structural basis for thrombin activation of a protease-activated receptor: Inhibition of intramolecular liganding. Chemistry and Biology 2003;10(11):1033-104. PubMed Abstract

Surks HK, Richards CT, Mendelsohn ME. Myosin phosphatase-RhoA interacting protein: A new member of the myosin phosphatase complex that directly binds RhoA. (SCOR) The Journal of Biological Chemistry 2003;278(51):51484-51493. PubMed Abstract

Mendelsohn ME. WHI Publishes additional data analysis regarding CHD effects with EPT (Commentary). (SCOR) North American Menopause Society First-to-Know Series, 2003.

Morin DP, Konstam MA, Mendelsohn ME, Udelson JE. Heart failure in women: Epidemiology, gender differences in pathophysiology, and implecations for therapy. In. (SCOR) Women and Coronary Disease, 2003;Shaw LJ, Redberg RF (eds.), Humana Press.Chapter 6:65-91.

Tang M, Wang G, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME. Regulator of G-protein signaling 2 mediator vascular smooth muscle relaxation and blood pressure. (SCOR) Nature Medicine 2003;9(12):1506-1512. PubMed Abstract

Konstam MA, Patten RD. Inhibition of the renin-angiotensin system. In. Heart Failure Management: A Companion to Braunwald’s Heart Disease, 2003;W.B. Saunders, New York.Chapter 38:603-618.

Van Eickels M, Patten RD, Aronovitz MJ, Alsheikh-Ali A, Gostyla K, Celestin F, Grohe C, Mendelsohn ME, Karas RH. 17-β-estradiol increases cardiac remodeling and mortality in mice with myocardial infarction. See correction at volume 42(1). (SCOR) Journal of the American College of Cardiology 2003;41(11):2084-2092. PubMed Abstract

Thompson PD, Clarkson P, Karas RH. Statin-associated myopathy. The Journal of the American Medical Association 2003;289(13):1681-1690. PubMed Abstract

Surks HK, Mendelsohn ME. Dimerization of cGMP-dependent protein kinase 1β and the myosin binding subunit of myosin phosphatase: Role of leucine zipper domains. (SCOR) Cellular Signalling 2003;15(10):937-944. PubMed Abstract

Kuvin JT, Gokce N, Holbrook M, Hunter LM, Patel AR, Sliney KA, Craven DE, Grayston JT, Keaney JF, Karas RH, Vita JA. Effect of short-term antibiotic treatment on chlamydia pneumoniae and peripheral endothelial function. The American Journal of Cardiology 2003;91(6):732-735. PubMed Abstract

Haq S, Michael A, Andreucci M, Bhattacharya K, Dotto P, Walters B, Woodgett J, Kilter H, Force T. Stabilization of β-catenin by a wnt-independent mechanism regulates cardiomyocyte growth. Proceedings of the National Academy of Sciences, USA 2003;100(8):4610-4615. PubMed Abstract