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Molecular Cardiology Research Institute

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2012 Publications

Ueda K, Karas RH. Emerging evidence of the importance of rapid, non-nuclear estrogen receptor signaling in the cardiovascular system. Steroids. 2012 Dec 29. [Epub ahead of print].  Pubmed Abstract

Zhao J, Imbrie GA, Baur WE, Iyer LK, Aronovitz MJ, Kershaw TB, Haselmann GM, Lu Q, Karas RH. Estrogen Receptor-Mediated Regulation of MicroRNA Inhibits Proliferation of Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):257-65. Epub 2012 Nov 21. Pubmed Abstract


Blanton RM, Takimoto E, Lane A, Piotrowski R, Aronovitz M, Karas RH, Kass DA, Mendelsohn M. Protein kinase Gl Ialpha inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo.  J Am Hrt Assoc. 2012 Oct;1(5):e003731. Pubmed Abstract


Mangili A, Ahmad R, Wolfert RL, Kuvin J, Polak J, Karas RH, Wanke CA. Lipoprotein-associated phospholipase A2 (Lp-PLA2), a novel cardiovascular inflammatory marker, in HIV-infected patients. JAIDS 2012 (In Press)


Kato M, Blanton R, Wang GR, Judson TJ, Abe Y, Myoishi M, Karas RH, Mendelsohn ME. Direct Binding and Regulation of RhoA by cyclic GMP-dependent protein kinase I & α. J Biol Chem. 2012 [Epub ahead of print] Pubmed Abstract


Ehsan A, McGraw AP, Aronovitz MJ, Galayda C, Conte MS, Karas RH, Jaffe IZ. Mineralocorticoid receptor antagonism inhibits vein graft remodeling in mice. J Thorac Cardiovasc Surg. 2012 Sep 13. pii: S0022-5223(12)00955-5. doi: 10.1016/j.jtcvs.2012.08.007. [Epub ahead of print]. Pubmed Abstract


Benelot Moens SJ, Schnitzler GR, Nickerson M, Guo H, Ueda K, Lu Q, Aronovitz M,  Nickerson H, Baur W, Hansen U, Iyer LK, Karas RH.    Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury. Circulation. 2012; 126:1993-2004 Pubmed Abstract

McCurley A, Pires PW, Bender SB, Aronovitz M, Zhao MJ, Metzger D, Chambon P, Hill MA, Dorrance AM, Mendelsohn ME, Jaffe IZ. Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med. 2012 Aug 26. doi: 10.1038/nm.2891. Pubmed Abstract 

Al-Quthami AH, Jumean M, Kociol R, Pham DT, Kiernan M, Denofrio D, Kapur NK. Eptifibatide for the Treatment of HeartMate II Left Ventricular Assist Device Thrombosis. Circ Heart Fail. 2012 Jul 1;5(4):e68-70. No abstract available.

Thinh Pham D, Al-Quthami A, Kapur NK. Percutaneous left ventricular support in cardiogenic shock and severe aortic regurgitation. Catheter Cardiovasc Interv. 2012 May 28. doi: 10.1002/ccd.24501. [Epub ahead of print]. Pubmed Abstract 

Kapur NK, Wilson S, Yunis AA, Qiao X, Mackey E, Paruchuri V, Baker C, Aronovitz MJ, Karumanchi SA, Letarte M, Kass DA, Mendelsohn ME, Karas RH. Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure. Circulation. 2012 Jun 5;125(22):2728-38. Epub 2012 May 16. Pubmed Abstract 
Barbati C, Pierdominici M, Gambardella L, Malchiodi Albedi F, Karas RH, Rosano G, Malorni W, Ortona E. Cell Surface Estrogen Receptor Alpha Is Upregulated during Subchronic Metabolic Stress and Inhibits Neuronal Cell Degeneration. PLoS One. 2012;7(7):e42339. Epub 2012 Jul 31. Pubmed Abstract 
Doyle JR, Fortin JP, Beinborn M, Kopin AS. Selected melanocortin 1 receptor single-nucleotide polymorphisms differentially alter multiple signaling pathways. J Pharmacol Exp Ther. 2012 Aug;342(2):318-26. Epub 2012 Apr 30. Pubmed Abstract 

Peter I, McCaffery JM, Kelley-Hedgepeth A, Hakonarson H, Reis S, Wagenknecht LE, Kopin AS, Huggins GS. Association of Type 2 Diabetes Susceptibility Loci With One-Year Weight Loss in the Look AHEAD Clinical Trial. Obesity (Silver Spring). 2012 Aug;20(8):1675-82. doi: 10.1038/oby.2012.11. Epub 2012 Feb 6. Pubmed Abstract 

Myers RB, Rwayitare K, Richey L, Lem J, Castellot JJ Jr. CCN5 Expression in mammals. III. Early embryonic mouse development. J Cell Commun Signal. 2012 Aug 28. [Epub ahead of print]. Pubmed Abstract 


Makino CL, Wen XH, Michaud NA, Covington HI, DiBenedetto E, Hamm HE, Lem J, Caruso G. Rhodopsin expression level affects rod outer segment morphology and photoresponse kinetics. PLoS One. 2012;7(5):e37832. Epub 2012 May 25. Pubmed Abstract 

Kyriakis JM, Avruch J. Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.  Physiol Rev. 2012 Apr;92(2):689-737. Article


Kapur NK, Shenoy C, Yunis AA, Mohammad NN, Wilson S, Paruchuri V, Mackey EE, Qiao X, Shah A, Esposito ML, Karas RH, Jaffe IZ.  Distinct Effects of Unfractionated Heparin versus Bivalirudin on Circulating Angiogenic Peptides. PLoS One. 2012;7(4):e34344. Epub 2012 Apr 11. Pubmed Abstract


Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH. Difference in Th1 and th17 lymphocyte adhesion to endothelium. J Immunol. 2012 Feb;188(3):1421-30. Pubmed Abstract

Albano AJ, Thompson PD, Kapur NK. Acute coronary thrombosis in Boston marathon runners. N Engl J Med. 2012 Jan;366(2):184-5. Pubmed Abstract


Sims HI, Pham CD, Schnitzler GR. Mapping assembly favored and remodeled nucleosome positions on polynucleosomal templates. Methods Mol Biol. 2012;833:311-36. Pubmed Abstract