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Molecular Cardiology Research Institute
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2013 Publications

Mangili A, Ahmad R, Wolfert RL, Kuvin J, Polak JF, Karas RH, Wanke CA. Lipoprotein-Associated Phospholipase A2, a Novel Cardiovascular Inflammatory Marker, in HIV-Infected Patients. Clin Infect Dis. 2014 Jan 2. [Epub ahead of print].  Pubmed Abstract 

 

Yoneyama S, Guo Y, Lanktree MB, Barnes MR, Elbers CC, Karczewski KJ, Padmanabhan S, Bauer F, Baumert J, Beitelshees A, Berenson GS, Boer JM, Burke G, Cade B, Chen W, Cooper-Dehoff RM, Gaunt TR, Gieger C, Gong Y, Gorski M, Heard-Costa N, Johnson T, Lamonte MJ, McDonough C, Monda KL, Onland-Moret NC, Nelson CP, O'Connell JR, Ordovas J, Peter I, Peters A, Shaffer J, Shen H, Smith E, Speilotes L, Thomas F, Thorand B, Monique Verschuren WM, Anand SS, Dominiczak A, Davidson KW, Hegele RA, Heid I, Hofker MH, Huggins GS, Illig T, Johnson JA, Kirkland S; the Look AHEAD Research Group, König W, Langaee TY, McCaffery J, Melander O, Mitchell BD, Munroe P, Murray SS, Papanicolaou G, Redline S, Reilly M, Samani NJ, Schork NJ, Van Der Schouw YT, Shimbo D, Shuldiner AR, Tobin MD, Wijmenga C, Yusuf S; the GIANT Consortium; the CARe IBC Consortium, Hakonarson H, Lange LA, Demerath EW, Fox CS, North KE, Reiner AP, Keating B, Taylor KC. Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. Hum Mol Genet. 2014 Jan 6. [Epub ahead of print].  Pubmed Abstract

 

Rajab M, Jin H, Welzig CM, Albano A, Aronovitz M, Zhang Y, Park HJ, Link MS, Noujaim SF, Galper JB. Increased inducibility of ventricular tachycardia and decreased heart rate variability in a mouse model for type 1 diabetes: effect of pravastatin. Am J Physiol Heart Circ Physiol. 2013 Dec;305(12):H1807-16. doi: 10.1152/ajpheart.00979.2012. Pubmed Abstract
 
Wu MP, Doyle JR, Barry B, Beauvais A, Rozkalne A, Piao X, Lawlor MW, Kopin AS, Walsh CA, Gussoni E. G-protein coupled receptor 56 promotes myoblast fusion through serum response factor- and nuclear factor of activated T-cell-mediated signalling but is not essential for muscle development in vivo. FEBS J. 2013 Dec;280(23):6097-113. doi: 10.1111/febs.12529.  Pubmed Abstract

 

Heard KR, Wu W, Li Y, Zhao P, Woznica I, Lai JH, Beinborn M, Sanford DG, Dimare MT, Chiluwal AK, Peters DE, Whicher D, Sudmeier JL, Bachovchin WW. A General Method for Making Peptide Therapeutics Resistant to Serine Protease Degradation: Application to Dipeptidyl Peptidase IV Substrates. J Med Chem. 2013 Nov 14;56(21):8339-51. doi: 10.1021/jm400423p. Pubmed Abstract

 

Chen HH, Anstrom KJ, Givertz MM, Stevenson LW, Semigran MJ, Goldsmith SR, Bart BA, Bull DA, Stehlik J, LeWinter MM, Konstam MA, Huggins GS, Rouleau JL, O'Meara E, Tang WH, Starling RC, Butler J, Deswal A, Felker GM, O'Connor CM, Bonita RE, Margulies KB, Cappola TP, Ofili EO, Mann DL, Dávila-Román VG, McNulty SE, Borlaug BA, Velazquez EJ, Lee KL, Shah MR, Hernandez AF, Braunwald E, Redfield MM; NHLBI Heart Failure Clinical Research Network. Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial. JAMA. 2013 Dec 18;310(23):2533-43. doi: 10.1001/jama.2013.282190. [PubMed - indexed for MEDLINE].  Pubmed Abstract

 

McCaffery JM, Papandonatos GD, Huggins GS, Peter I, Erar B, Kahn SE, Knowler WC, Lipkin EW, Kitabchi AE, Wagenknecht LE, Wing RR; Genetic Subgroup of Look AHEAD; Look AHEAD Research Group. Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the look AHEAD trial. Hum Hered. 2013;75(2-4):160-74. doi: 10.1159/000353181.  Pubmed Abstract

 

Dupont JJ, Hill MA, Bender SB, Jaisser F, Jaffe IZ. Aldosterone and Vascular Mineralocorticoid Receptors: Regulators of Ion Channels Beyond the Kidney. Hypertension. 2013 Dec 30. [Epub ahead of print] No abstract available. [PubMed - as supplied by publisher]. Pubmed Abstract

 

Holwerda KM, Burke SD, Faas MM, Zsengeller Z, Stillman IE, Kang PM, van Goor H, McCurley A, Jaffe IZ, Karumanchi SA, Levy AT. Hydrogen Sulfide Attenuates sFlt1-Induced Hypertension and Renal Damage by Upregulating Vascular Endothelial Growth Factor. J Am Soc Nephrol. 2013 Dec 12. [Epub ahead of print]. [PubMed - as supplied by publisher]. Pubmed Abstract

 

Pruthi D, McCurley A, Aronovitz M, Galayda C, Karumanchi SA, Jaffe IZ. Aldosterone Promotes Vascular Remodeling by Direct Effects on Smooth Muscle Cell Mineralocorticoid Receptors. Arterioscler Thromb Vasc Biol. 2013 Dec 5. [Epub ahead of print]. Pubmed Abstract
 
Galmiche G, Pizard A, Gueret A, Moghrabi SE, Ouvrard-Pascaud A, Berger S, Challande P, Jaffe IZ, Labat C, Lacolley P, Jaisser F. Smooth Muscle Cell Mineralocorticoid Receptors Are Mandatory for Aldosterone-Salt to Induce Vascular Stiffness.  Hypertension. 2013 Dec 2. [Epub ahead of print]. Pubmed Abstract 


Wang D, Fan G, Wang Y, Liu H, Wang B, Dong J, Zhang P, Zhang B, Karas RH, Gao X, Zhu Y. Vascular reactivity screen of Chinese medicine danhong injection identifies Danshensu as a NO-independent but PGI2-mediated relaxation factor. J Cardiovasc Pharmacol. 2013 Nov;62(5):457-65. doi: 10.1097/FJC.0b013e3182a29657. Pubmed Abstract

 

Kong Q, Blanton RM. Protein kinase g I and heart failure: shifting focus from vascular unloading to direct myocardial antiremodeling effects. Circ Heart Fail. 2013 Nov 1;6(6):1268-83. doi:10.1161/CIRCHEARTFAILURE.113.000575. No abstract available. Pubmed Abstract

 

Blanton RM, Takimoto E, Aronovitz M, Thoonen R, Kass DA, Karas RH, Mendelsohn ME. Mutation of the protein kinase I alpha leucine zipper domain produces hypertension and progressive left ventricular hypertrophy: a novel mouse model of age-dependent hypertensive heart disease. J Gerontol A Biol Sci Med Sci. 2013 Nov;6(11):1351-5. doi: 10.1093/gerona/glt042. Pubmed Abstract

 

Baranyi U, Gattringer M, Farkas AM, Hock K, Pilat N, Iacomini J, Valenta R, Wekerle T. The site of allergen expression in hematopoietic cells determines the degree and quality of tolerance induced through molecular chimerism. Eur J Immunol. 2013 Sep;43(9):2451-60. doi: 10.1002/eji.201243277. Pubmed Abstract

 

Gattringer M, Baranyi U, Pilat N, Hock K, Klaus C, Buchberger E, Ramsey H, Iacomini J, Valenta R, Wekerle T. Engraftment of retrovirally transduced Bet v 1-GFP expressing bone marrow cells leads to allergen-specific tolerance. Immunobiology. 2013 Sep;218(9):1139-46. doi: 10.1016/j.imbio.2013.03.007. Pubmed Abstract

 

Toth PP, Barter PJ, Rosenson RS, Boden WE, Chapman MJ, Cuchel M, D'Agostino RB Sr, Davidson MH, Davidson WS, Heinecke JW, Karas RH, Kontush A, Krauss RM, Miller M, Rader DJ. High-density lipoproteins: a consensus statement from the National Lipid Association. J Clin Lipidol. 2013 Sep-Oct;7(5):484-525. doi: 10.1016/j.jacl.2013.08.001. Pubmed Abstract

 

Wang GR, Surks HK, Tang KM, Zhu Y, Mendelsohn ME, Blanton RM. Steroid-sensitive gene 1 is a novel cyclic GMP-dependent protein kinase I substrate in vascular smooth muscle cells. J Biol Chem. 2013 Aug 23;288(34):24972-83. doi: 10.1074/jbc.M113.456244. Pubmed Abstract

 

Ueda K, Lu Q, Baur W, Aronovitz MJ, Karas RH. Rapid estrogen receptor signaling mediates estrogen-induced inhibition of vascular smooth muscle cell proliferation. Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1837-43. doi: 10.1161/ATVBAHA.112.300752. Epub 2013 Jun 6.  Pubmed Abstract

 

Kapur NK, Paruchuri V, Aronovitz MJ, Qiao X, Mackey EE, Daly GH, Ughreja K, Levine J, Blanton R, Hill NS, Karas RH. Biventricular remodeling in murine models of right ventricular pressure overload. PLoS One. 2013 Jul 30;8(7):e70802. doi: 10.1371/journal.pone.0070802. Pubmed Abstract

 

Kapur NK, Paruchuri V, Urbano-Moral JA, Mackey EE, Daly G, Qiao X, Pandian NG, Perides G, Karas RH. Mechanically Unloading the Left Ventricle Before Coronary Reperfusion Reduces Left Ventricular Wall Stress and Myocardial Infarct Size. Circulation. 2013 Jun 13. [Epub ahead of print]. Pubmed Abstract  

 
Korabathina R, Weintraub AR, Price LL, Kapur NK, Kimmelstiel CD, Iafrati MD, Tahir SM. A 20-Year Analysis of Trends in the Incidence and In-Hospital Mortality for Lower Extremity Arterial Thromboembolism. Circulation. 2013 Jun 5. [Epub ahead of print]. Pubmed Abstract 


Kapur NK, Morine KJ, Letarte M. Endoglin: a critical mediator of cardiovascular health. Vasc Health Risk Manag. 2013;9:195-206. doi: 10.2147/VHRM.S29144. Epub 2013 May 6. Pubmed Abstract 


Nagy CD, Jumean MF, Pham DT, Kiernan MS, Denofrio D, Kapur NK. Percutaneous circulatory support for biventricular failure. Circ Cardiovasc Interv. 2013 Apr;6(2):e12-4. Pubmed Abstract


Ueda K, Lu Q, Baur W, Aronovitz MJ, Karas RH. Rapid Estrogen Receptor Signaling Mediates Estrogen-Induced Inhibition of Vascular Smooth Muscle Cell Proliferation. Arterioscler Thromb Vasc Biol. 2013 Jun 6. [Epub ahead of print]. Pubmed Abstract


Blanton RM, Takimoto E, Aronovitz M, Thoonen R, Kass DA, Karas RH, Mendelsohn ME. Mutation of the Protein Kinase I Alpha Leucine Zipper Domain Produces Hypertension and Progressive Left Ventricular Hypertrophy: A Novel Mouse Model of Age-Dependent Hypertensive Heart Disease. J Gerontol A Biol Sci Med Sci. 2013 May 8. [Epub ahead of print]. Pubmed Abstract


Heffernan KS, Wanke CA, Dong K, Warner PJ, Anskat PE, Karas RH, Kuvin JT. Racial differences in central hemodynamic burden in men with HIV: preliminary findings. Ethn Dis. 2013 Spring;23(2):217-22. Pubmed Abstract 


Ueda K, Karas RH. Emerging evidence of the importance of rapid, non-nuclear estrogen receptor signaling in the cardiovascular system. Steroids. 2013 Jun;78(6):589-96. doi: 10.1016/j.steroids. Pubmed Abstract 


Pancaro C, Nasr VG, Paulus JK, Bonney I, Flores AF, Galper JB, Ahmed I. Phenylephrine as a simulated intravascular epidural test dose in pediatrics: a pilot study. Paediatr Anaesth. 2013 Jun;23(6):502-9. doi: 10.1111/pan.12157. Epub 2013 Mar 28. Pubmed Abstract 


McCaffery JM, Papandonatos GD, Huggins GS, Peter I, Kahn SE, Knowler WC, Hudnall GE, Lipkin EW, Kitabchi AE, Wagenknecht LE, Wing RR. FTO predicts weight regain in the Look AHEAD clinical trial. Int J Obes (Lond). 2013 Apr 3. doi: 10.1038/ijo.2013.54. [Epub ahead of print]. Pubmed Abstract


Warner PJ, Al-Quthami A, Brooks EL, Kelley-Hedgepeth A, Patvardhan E, Kuvin JT, Heffernan KS, Huggins GS. Augmentation index and aortic stiffness in bicuspid aortic valve patients with non-dilated proximal aortas. BMC Cardiovasc Disord. 2013 Mar 15;13:19. doi: 10.1186/1471-2261-13-19. Pubmed Abstract 


Wachman EM, Hayes MJ, Brown MS, Paul J, Harvey-Wilkes K, Terrin N, Huggins GS, Aranda JV, Davis JM. Association of OPRM1 and COMT single-nucleotide polymorphisms with hospital length of stay and treatment of neonatal abstinence syndrome. JAMA. 2013 May 1;309(17):1821-7. Pubmed Abstract 

 

Barrett K, McCurley A, Jaffe IZ. Direct Contribution of Vascular Mineralocorticoid Receptors to Blood Pressure Regulation. Clin Exp Pharmacol Physiol. 2013 May 25. doi: 10.1111/1440-1681.12125. [Epub ahead of print]. Pubmed Abstract


McGraw AP, McCurley A, Preston IR, Jaffe IZ. Mineralocorticoid receptors in vascular disease: connecting molecular pathways to clinical implications. Curr Atheroscler Rep. 2013 Jul;15(7):340. doi: 10.1007/s11883-013-0340-x. Pubmed Abstract 

 

McCurley A, McGraw A, Pruthi D, Jaffe IZ. Smooth muscle cell mineralocorticoid receptors: role in vascular function and contribution to cardiovascular disease. Pflugers Arch. 2013 May 1. [Epub ahead of print]. Pubmed Abstract

 

Doyle JR, Lane JM, Beinborn M, Kopin AS. Naturally occurring HCA1 missense mutations result in loss of function: potential impact on lipid deposition. J Lipid Res. 2013 Mar;54(3):823-30. Pubmed Abstract  

 

Bender SB, McGraw AP, Jaffe IZ, Sowers JR. Mineralocorticoid receptor-mediated vascular insulin resistance: an early contributor to diabetes-related vascular disease? Diabetes. 2013 Feb;62(2):313-9. Pubmed Abstract

 

Kapur NK, Imbrie GA. Cardiac allograft vasculopathy: vulnerable patients, not vulnerable plaques. Catheter Cardiovasc Interv. 2013 Feb;81(3):436-7. doi: 10.1002/ccd.24822. No abstract available.

 

Kapur NK. Invasive thoughts: circulatory support devices in the catheterization laboratory: evolution or revolution? J Invasive Cardiol. 2013 Feb;25(2):62-3. No abstract available.

 

Kapur NK, Jumean MF. Defining the Role for Percutaneous Mechanical Circulatory Support Devices for Medically Refractory Heart Failure. Curr Heart Fail Rep. 2013 Feb 7. [Epub ahead of print]. Pubmed Abstract 

 

Wooten EC, Hebl VB, Wolf MJ, Greytak SR, Orr NM, Draper I, Calvino JE, Kapur NK, Maron MS, Kullo IJ, Ommen SR, Bos JM, Ackerman MJ, Huggins GS. Formin homology 2 domain containing 3 variants associated with hypertrophic cardiomyopathy. Circ Cardiovasc Genet. 2013 Feb 1;6(1):10-8. Pubmed Abstract

 

Lavigne PM, Karas RH. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression. J Am Coll Cardiol. 2013 Jan 29;61(4):440-6. Pubmed Abstract

  

Miller VM, Petterson TM, Jeavons EN, Lnu AS, Rider DN, Heit JA, Cunningham JM, Huggins GS, Hodis HN, Budoff MJ, Santoro N, Hopkins PN, Lobo RA, Manson JE, Naftolin F, Taylor HS, Harman SM, de Andrade M. Genetic polymorphisms associated with carotid artery intima-media thickness and coronary artery calcification in women of the Kronos Early Estrogen Prevention Study. Physiol Genomics. 2013 Jan 22;45(2):79-88. Pubmed Abstract

 

Harwood BN, Fortin JP, Gao K, Chen C, Beinborn M, Kopin AS. Membrane tethered bursicon constructs as heterodimeric modulators of the Drosophila GPCR rickets. Mol Pharmacol. 2013 April; 83 (4):814-21. Pubmed Abstract