Jamie Doyle, Ph.D.

Dr. Jamie Doyle received her B.S. in Chemistry from Wake Forest University in 2002. She then moved to Boston and received her Ph.D. from Boston University.  Jamie completed her thesis work in Pharmacology in the Neurochemistry Laboratory of Dr. Bryan Yamamoto, studying the effects of chronic stress on the toxicity of the drug of abuse methamphetamine. Dr. Doyle joined the MPRC in 2009.  The focus of her research is on the characterization of G-protein coupled receptor (GPCR) variants that are associated with diabetes and obesity.  The GPCRs selected for pharmacological characterization are based upon the genetic association of GPCR non-synonymous SNPs with clinical data from the Look AHEAD (Action for Health in Diabetes) study, a randomized 4 year lifestyle intervention trial of ~5,000 obese subjects with type-2 diabetes.  GPCR variant characterization includes assessment of receptor affinity, potency, second messenger signaling, and expression.