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Molecular Cardiology Research Institute
Staff Directory
Principal Investigators









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Daniel Cox, Ph.D.

  Associate Professor
Laboratory of Biophysics and Cellular Physiology

Tufts Medical Center

800 Washington Street, Box 7868

Boston, MA 02111

    617-636-7868

Daniel Cox

 

 Biosketch




Daniel Cox is an Associate Professor in the Molecular Cardiology Research Institute and in the Department of Neuroscience at Tufts University’s School of Medicine. After receiving his B.A in chemistry at the University of Virginia in 1986, Dr. Cox earned a Ph. D. in Neuroscience from Tufts in 1993. He then did six years of postdoctoral research at Stanford University before joining the MCRI faculty in 1999.

 

Research Administrator: Dionne Marshall

Key Publications

Sweet TB, Cox DH.  Measuring the influence of the BKca β1 subunit on Ca²+ binding to the BKca channel.  Journal of General Physiology 2009;133(2):139-150.  PubMed Abstract

 

Sweet TB, Cox DH.  Measurements of the BKCa channel's high-affinity Ca2+ binding constants: effects of membrane voltage.  Journal of General Physiology 2008;132(5):491-505.  PubMed Abstract

 

Kelley-Hedgepeth A, Peter I, Kip KE, Montefusco MC, Kogan S, Cox D, Ordovas JM, Levy D, Reis SE, Mendelsohn ME, Housman D, Huggins GS.  The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with β-blockade.  Journal of Human Hypertension 2008;22(7):512-515.  PubMed Abstract

 

Kim HJ, Lim HH, Rho SH, Bao L, Lee JH, Cox DH, Kim DH, Park CS.  Modulation of the Conductance-Voltage Relationship of the BKCa Channel by Mutations at the Putative Flexible Interface Between Two RCK Domains.  Biophysical Journal 2007;94(2):446-456.  PubMed Abstract

 

Isacson CK, Lu Q, Karas RH,Cox DH.  RACK1 is a BKCa channel binding protein.  American Journal of Physiology - Cell Physiology 2006;292(4):C1459-C1466.  PubMed Abstract

 

Cox DH. BKCa-Channel Structure and Function. 2006; in: Biological Membrane Ion Channels,Chung, Shin-Ho; Andersen, Olaf S.; Krishnamurthy, Vikram (Eds.). Chapter 5:171-219

 

Bao L, Cox DH. Gating and ionic currents reveal how the BKCa channel's Ca2+ sensitivity Is enhanced by its β1 subunit.  Journal of General Physiology 2005;126(4):393-412.  PubMed Abstract

 

Cox DH.  The BKCa channel's Ca2+-binding sites, multiple sites, multiple ions.  Journal of General Physiology 2005;125(3):253-255.  PubMed Abstract

 

Bao, L., Kaldany, C. Holmstrand, E. C..and Cox, D.H.  Mapping the BK Ca channel’s

“Ca 2+ Bowl”: Side-Chains Essential for Ca 2+ Sensing J. Gen. Physiol. 2004;121: 475-489. PubMed Abstract

 

Bao, L., Rapin A.M., Holmstrand E.C., and Cox, D.H.  Elimination of the BK Ca Channel's High-Affinity Ca 2+ Sensitivity J. Gen. Physiol. 2002;120: 173-189.  PubMed Abstract

 

Zhu, Y., Bian, Z., Lu, P., Karas, R. H., Bao, L., Cox, D., Hodgin, J., Shaul, P. W., Thoren, P., Smithies, O., Gustafsson, J. A., and Mendelsohn, M. E. Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science 2002;295, 505-8.  PubMed Abstract

 

Cox, D. H. and Aldrich, R. W. Role of the b 1 Subunit in Large-Conductance Ca 2+ -activated K + Channel Gating Energetics: Mechanisms of Enhanced Ca 2+ Sensitivity Journal of General Physiology 2000;116(3), 411-432.  PubMed Abstract

 

Cox, D. H., Cui, J., and Aldrich, R. W. Allosteric gating of a large conductance Ca-activated K + Channel. Journal of General Physiology 1997;110, 257-281.  PubMed Abstract


Cox, D. H., Cui, J., and Aldrich, R. W. Separation of gating properties from permeation and block in mSlo large conductance Ca-activated K + channels. Journal of General Physiology 1997;109, 633-46.  PubMed Abstract


Cui, J., Cox, D. H., and Aldrich, R. W. Intrinsic voltage dependence and Ca 2+ regulation of mSlo large conductance Ca-activated K + channels. Journal of General Physiology 1997;109, 647-73.  PubMed Abstract