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Molecular Cardiology Research Institute
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Principal Investigators









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Gavin Schnitzler, Ph.D.

  Assistant Professor
Molecular Cardiology Research Center

Tufts Medical Center

800 Washington Street, Box 080

Boston, MA 02111

    617-636-0615

Gavin Shnitzler




Dr. Schnitzler is an Assistant Professor in Medicine at Tufts University School of Medicine and an Investigator in the Molecular Cardiology Research Institute. Dr. Schnitzler received a B.A. in Biochemistry and in Psychology from Swarthmore College in 1987, and a Ph.D. in Biology from U.C. San Diego in 1993. Dr. Schnitzler completed his post-doctoral training, as a Helen Hay Whitney fellow in the laboratory of Dr. Robert Kingston at Mass. General Hospital/Harvard Medical School, in 1999. Dr. Schnitzler began his independent studies in the Biochemistry Department at TUSM, and moved to the MCRI in 2009.

 

Dr. Schnitzler’s laboratory is studying the molecular mechanisms by which estrogen binding to the estrogen receptor alpha (ER alpha) transcription factor can promote vascular healing after injury and protect against cardiovascular disease. His laboratory uses transgenic mouse and cell culture models, together with molecular biological, biochemical, genomic and bioinformatic approaches to examine how the effects of ER alpha on signal transduction pathways and chromatin structure modulate target gene expression to control inflammatory reactions and vascular cell functions.

 

 

Recent Publications

Gordon FK, Vallaster CS, Westerling T, Iyer LK, Brown M, Schnitzler GR. Research resource: Aorta- and liver-specific ERα-binding patterns and gene regulation by estrogen. Mol Endocrinol. 2014 Aug;28(8):1337-51. doi: 10.1210/me.2013-1395. Epub 2014 Jul 3. Pubmed Abstract

 

Bernelot Moens SJ, Schnitzler GR, Nickerson M, Guo H, Ueda K, Lu Q, Aronovitz MJ, Nickerson H, Baur WE, Hansen U, Iyer LK, Karas RH. Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury.Circulation. 2012 Oct 16;126(16):1993-2004. doi: 10.1161/CIRCULATIONAHA.112.124529. Epub 2012 Sep 20. Pubmed Abstract

 

Sims HI, Pham CD, Schnitzler GR.Mapping assembly favored and remodeled nucleosome positions on polynucleosomal templates. Methods Mol Biol. 2012;833:311-36. doi: 10.1007/978-1-61779-477-3_19. Pubmed Abstract

 

Pham CD, Sims HI, Archer TK, Schnitzler GR. Multiple distinct stimuli increase measured nucleosome occupancy around human promoters. PLoS One. 2011;6(8):e23490. doi: 10.1371/journal.pone.0023490. Epub 2011 Aug 11. Pubmed Abstract

 

Denis GV, Nikolajczyk BS, Schnitzler GR. An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis. FEBS Lett. 2010 Aug 4;584(15):3260-8. doi: 10.1016/j.febslet.2010.05.030. Epub 2010 May 21. Review. Pubmed Abstract

 

All Publications