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Molecular Cardiology Research Institute
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Principal Investigators









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Gordon Huggins, M.D.

  Associate Professor
MCRI Center for Translational Genomics

Tufts Medical Center

800 Washington Street, Box 8486

Boston, MA 02111

    617-636-2807

Gordon Huggins




Dr. Huggins graduated from Boston University and Pritzker School of Medicine, University of Chicago. He completed his Internal Medicine residency and Clinical Cardiology Fellowship at the Massachusetts General Hospital, Harvard University. Prior to coming to the MCRI, he spent 4 years at The Massachusetts General Hospital in the Cardiology Division. Drs Edgar Haber, Mu-En Lee and Jeffrey Leiden trained Dr. Huggins in molecular biology at the Cardiovascular Biology Laboratory in the Harvard School of Public Health. Currently, he is the Director of the Laboratory of Cardiovascular Genetics of the MCRI and is an Associate Professor of Medicine at Tufts University School of Medicine.

 

Research Administrator: Dionne Marshall

Key Publications

Peter I, Hedgepeth AK, Huggins GS, Housman DE, Mendelsohn ME, Vita JA, Vasan RS, Levy D, Benjamin EJ, Mitchell GM.  Association between arterial stiffness and variations in estrogen-related genes.    Journal of Human Hypertension 2009;2009 Feb 5. [Epub ahead of print]  PubMed Abstract

 

Kelley-Hedgepeth A, Peter I, Montefusco MC, Levy D, Benjamin EJ, Vasan RS, Mendelsohn ME, Housman D, Huggins GS, Mitchell GF.  The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort.    Journal of Hypertension 2009;27(1):55-60.  PubMed Abstract

 

Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS.  Deletion of GSK-3β in Mice Leads to Hypertrophic Cardiomyopathy Secondary to Cardiomyoblast Hyperproliferation.    Journal of Clinical Investigation 2008;118(11):3609-3618.  PubMed Abstract

 

Rouf R, Greytak S, Wooten EC, Wu J, Boltax J, Picard M, Svensson EC, Dillmann WH, Patten RD, Huggins GS.  Increased FOG-2 in failing myocardium disrupts thyroid hormone-dependent SERCA2 gene transcription.    Circulation Research 2008;103(5):493-501.  PubMed Abstract

 

Peter I, Kelley-Hedgepeth A, Fox CS, Cupples LA, Huggins GS, Housman DE, Karas RH, Mendelsohn ME, Levy D, Murabito JM.  Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels.    Journal of Clinical Endocrinology & Metabolism 2008;93(7):2779-2785.  PubMed Abstract

 

Kelley-Hedgepeth A, Peter I, Kip KE, Montefusco MC, Kogan S, Cox D, Ordovas JM, Levy D, Reis SE, Mendelsohn ME, Housman D, Huggins GS.  The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with ß-blockade.    Journal of Human Hypertension 2008;22(7):512-515.  PubMed Abstract

 

Wong JY, Huggins GS, Debidda M, Munshi NC, De Vivo I.  Dichloroacetate induces apoptosis in endometrial cancer cells.    Gynecologic Oncology 2008;109(3):394-402.  PubMed Abstract

 

Huggins GS, Lepore JJ, Greytak S, Patten RD, McNamee R, Aronovitz MJ, Wang P, Reed GL.  The CREB leucine zipper regulates CREB phosphorylation, cardiomyopathy, and lethality in a transgenic model of heart failure.    American Journal of Physiology - Heart and Circulatory Physiology 2007;293(3):H1877-H1882.  PubMed Abstract

 

Peter I, Huggins GS, Shearman AM, Pollak A, Schmid CH, Cupples, Demissie S, Patten RD, Karas RH, Housman DE, Mendelsohn ME, Vasan RS, Benjamin EJ.  Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-α gene.    Hypertension 2007;49(5):1000-1006.  PubMed Abstract

 

Huggins GS Wang JY, Hankinson SE, De Vivo I.  GATA5 activation of the progesterone receptor gene promoter in breast cancer cells is influenced by the +331G/A polymorphism.    Cancer Research 2006;66(3):1384-1390.  PubMed Abstract

 

Huggins GS, Gewirte H.  Chronic stable angina: Clinical presentation and diagnostic techniques. In:    Atherothrombosis and Coronary Artery Disease, 2005;Fuster V, Topol EJ, Nabel,Chapter 88:1301-1312. 

 

Huggins GS, O'Gara PT.  Clinical presentation and diagnostic evaluation of ST-segment elevation myocardial infarction. In:    Atherothrombosis and Coronary Artery Disease, 2005;Fuster V, Topol EJ, Nabel,Chapter 50:849-866.

 

Michael A, Haq S, Chen X, Hsich E, Cui L, Walters B, Shao Z, Bhattacharya K, Kilter H, Huggins G, Andreucci M, Periasamy M, Solomon RN, Liao R, Patten R, Molkentin JD, Force T.  Glycogen synthase kinase-3ß regulates normal post-natal cardiac growth, calcium homeostasis and diastolic function of the heart.    Journal of Biological Chemistry 2004;279(20):21383-21393.  PubMed Abstract

 

Aikawa R, Huggins GS, Snyder RO.  Cardiomyocyte-specific gene expression following recombinant adeno-associated viral vector transduction.    Journal of Biological Chemistry 2002;277(21):18979-18985.  PubMed Abstract

 

Huggins GS, Bacani CJ, Boltax J, Aikawa R, Leiden JM. FOG-2 Represses COUP-TF2-Dependent Synergistic Activation of the Atrial Natriuretic Factor Promoter By GATA4. J Biol Chem 2001;276:28029-28036. PubMed Abstract

 

Aikawa R, Huggins G.S., Snyder R.O. ; Cardiomyocyte-specific gene expression following recombinant adeno-associated viral vector transduction. J Biol Chem. 2002;277:18979-18985. PubMed Abstract