Iris Jaffe, M.D., Ph.D.

Associate Professor
Molecular Cardiology Research Center

800 Washington Street, Box 080

Boston, MA 02111

617-636-0620

Iris Jaffe

Biosketch

Iris Zamir Jaffe is an Associate Professor of Medicine at Tufts University School of Medicine and a staff member of the Division of Cardiology at Tufts Medical Center. Dr. Jaffe is the co-Director of the MCRC and Chair of the Department of Medicine's Women in Medicine Committee. She received her M.D. and Ph.D. in Molecular Biology from the University of Pennsylvania in Philadelphia. She did her Ph.D. research in the laboratory of Dr. Mitchell Lazar where she studied the mechanism of transcriptional repression by nuclear hormone receptors. She trained as a medical resident at the Massachusetts General Hospital followed by a fellowship in Cardiology at Brigham and Women's Hospital. Iris completed her postdoctoral training in the laboratory of Michael Mendelsohn within the MCRI.

The Jaffe laboratory is studying the role of vascular mineralocorticoid receptors (MR) in vascular cell function and disease. The lab uses molecular approaches to study the mechanisms of gene regulation by MR in human vascular cells and employs animal models to study the role of MR in vascular dysfunction and atherosclerosis.

Working in the Jaffe Lab

Research Administrator: Patricia Griffiths-Rossiter

Publications

Jaffe IZ, Newfell BG, Aronovitz M, Mohammad NN, McGraw AP, Perreault RE, Carmeliet P, Ehsan A, and Mendelsohn ME. Placental Growth Factor Mediates Aldosterone-Dependent Vascular Injury. Journal of Clinical Investigation 2010; 120(11):3891-3900. PubMed Abstract

Caprio M, Mammi C, Jaffe IZ, Zennaro MC, Aversa A, Mendelsohn ME, Fabbri A, Rosano G. The mineralocorticoid receptor in endothelial physiology and disease: Novel concepts in the understanding of erectile dysfuction. Current Pharmaceutica Design 2008;14(35):3749-3757. PubMed Abstract

Schnoes KK, Jaffe IZ, Iyer L, Dabreo A, Aronovitz M, Newfell B, Hansen U, Rosano G, Mendelsohn ME. Rapid recruitment of temporally distinct vascular gene sets by estrogen. Molecular Endocrinol 2008;22(11):2544-2556. PubMed Abstract

Caprio M, Newfell BG, la Sala A, Baur W, Fabbri A, Rosano G, Mendelsohn ME, Jaffe IZ. Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion. Circulation Research 2008;102(11):1359-1367. PubMed Abstract

Jaffe IZ, Tintut Y, Newfell BG, Demer LL, Mendelsohn ME. Mineralcorticoid Receptor Activation Promotes Vascular Cell Calcification. Ateriosclerosis, Thrombosis and Vascular Biology 2007;27(4):799-805. PubMed Abstract

O’Lone R, Knorr K, Jaffe IZ, Schaffer M, Martini P, Karas RH, Bienkowska J, Mendelsohn ME, Hansen U. Estrogen Receptors ∝ and β Mediate Distinct Pathways of Vascular Gene Expression, Including Genes Involved in Mitochondrial Electron Transport and Generation of Reactive Oxygen Species. Molecular Endocrinol 2007;21(6):1281-1296. PubMed Abstract

Jaffe IZ, Mendelsohn ME. Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells. Circulation Research 2005;96(6):643-650. PubMed Abstract