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Peter I, Hedgepeth AK, Huggins GS, Housman DE, Mendelsohn ME, Vita JA, Vasan RS, Levy D, Benjamin EJ, Mitchell GM. Association between arterial stiffness and variations in estrogen-related genes. Journal of Human Hypertension 2009; 2009 Feb 5. [Epub ahead of print] PubMed Abstract
Takimoto E, Koitabashi N, Hsu S, Ketner EA, Zhang M, Nagayama T, Bedja D, Gabrielson KL, Blanton R, Siderovski DP, Mendelsohn ME, Kass DA. Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. Journal of Clinical Investigation 2009; 119(2):408-420. PubMed Abstract
Kelley-Hedgepeth A, Peter I, Montefusco MC, Levy D, Benjamin EJ, Vasan RS, Mendelsohn ME, Housman D, Huggins GS, Mitchell GF. The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort. Journal of Hypertension 2009; 27(1):55-60. PubMed Abstract
Caprio M, Mammi C, Jaffe IZ, Zennaro MC, Aversa A, Mendelsohn ME, Fabbri A, Rosano G. The mineralocorticoid receptor in endothelial physiology and disease: Novel concepts in the understanding of erectile dysfuction. Current Pharmaceutical Design 2008; 14(35):3749-3757. PubMed Abstract
Tsutsumi S, Zhang X, Takata K, Takahashi K, Karas RH, Kurachi H, Mendelsohn ME. Differen
tial regulation of the inducible nitric oxide synthase gene by estrogen receptors 1 and 2. Journal of Endocrinology 2008; 199(2):267-273. PubMed Abstrac
Sharma AK, Zhou GP, Kupferman J, Surks HK, Christensen EN, Chou JJ, Mendelsohn ME, Rigby AC. Probing the interaction between the coiled-coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C-terminus of the myosin binding subunit of the myosin light chain phosphatase. Journal of Biological Chemistry 2008; 283(47):32860-32869. PubMed Abstract
Schnoes KK, Jaffe IZ, Iyer L, Dabreo A, Aronovitz M, Newfell B, Hansen U, Rosano G, Mendelsohn ME. Rapid recruitment of temporally distinct vascular gene sets by estrogen. Molecular Endocrinology 2008; 22(11):2544-2556. PubMed Abstract
Caprio M, Newfell BG, la Sala A, Baur W, Fabbri A, Rosano G, Mendelsohn ME, Jaffe IZ. Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion. Circulation Research 2008; 102(11):1359-1367. PubMed Abstract
Peter I, Kelley-Hedgepeth A, Fox CS, Cupples LA, Huggins GS, Housman DE, Karas RH, Mendelsohn ME, Levy D, Murabito JM. Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels. Journal of Clinical Endocrinology & Metabolism 2008; 93(7):2779-2785. PubMed Abstract
Michael S, Surks HK, Wang Y, Zhu Y, Blanton R, Jamnongjit M, Aronovitz M, Baur W, Ohtani K, Wilkerson MK, Bonev AD, Nelson MT, Karas RH, Mendelsohn ME. High blood pressure arising from a defect in vascular function. Proceedings of the National Academy of Sciences, USA 2008; 105(18):6702-6707. PubMed Abstract
Kelley-Hedgepeth A, Peter I, Kip KE, Montefusco MC, Kogan S, Cox D, Ordovas JM, Levy D, Reis SE, Mendelsohn ME, Housman D, Huggins GS. The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with ß-blockade. Journal of Human Hypertension 2008; 22(7):512-515. PubMed Abstract
Patten RD, Pourati I, Aronovitz MJ, Alsheikh-Ali A, Eder S, Force T, Mendelsohn ME, Karas RH. 17 ß-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload. Journal of Cardiac Failure 2008; 14(3):245-253. PubMed Abstract
Mendelsohn ME, Karas RH. HRT and the Young at Heart. New England Journal of Medicine 2007; 356(25):2639-2641. PubMed Abstract
Peter I, Huggins GS, Shearman AM, Pollak A, Schmid CH, Cupples, Demissie S, Patten RD, Karas RH, Housman DE, Mendelsohn ME, Vasan RS, Benjamin EJ. Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-α gene. Hypertension 2007; 49(5):1000-1006. PubMed Abstract
Li HJ, Haque ZK, Chen A, Mendelsohn ME. RIF-1, a novel nuclear receptor corepressor that associates with the nuclear matrix. Journal of Cellular Biochemistry 2007; 102(4):1021-1035. PubMed Abstract
Jaffe IZ, Tintut Y, Newfell BG, Demer LL, Mendelsohn ME. Mineralocorticoid Receptor Activation Promotes Vascular Cell Calcification. Arteriosclerosis Thrombosis, and Vascular Biology 2007; 27(4):799-805. PubMed Abstract
O’Lone R, Knorr K, Jaffe IZ, Schaffer M, Martini P, Karas RH, Bienkowska J, Mendelsohn ME, Hansen U. Estrogen Receptors α and ß Mediate Distinct Pathways of Vascular Gene Expression, Including Genes Involved in Mitochondrial Electron Transport and Generation of Reactive Oxygen Species. Molecular Endocrinology 2007; 21(6):1281-1296. PubMed Abstract
Li J, Haque Z, Lu Q, Li L, Karas RH, Mendelsohn ME. Steroid receptor coactivator-3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation. Proceedings of the National Academy of Sciences, USA 2007; 104(10):4065-4070. PubMed Abstract
Mendelsohn ME, Karas RH. Molecular and cellular basis of cardiovascular gender differences. Science 2005;308(5728):1583-7. Science Abstract. Science Full Text
Wang Y, Surks H, Mendelsohn ME. Formin homology domain protein FHOD1 is a cyclic GMP-dependent protein kinase I binding protein and substrate in vascular smooth muscle cells. J Biol Chem. 2004;279(23):24420-6. PubMed Abstract
Akira Endo M.D., Ph.D., Howard K. Surks, M.D., Naoki Mochizuki M.D.,Ph.D. and Michael E. Mendelsohn, M.D. Identification and Characterization of Zipper-interacting Protein Kinase as the Unique Vascular Smooth Muscle Myosin Phosphatase-associated Kinase. J Biol Chem. 2004;279(40):42055-61. PubMed Abstract
Lu Q, Pallas DC, Surks HK, Baur WE, Mendelsohn ME, Karas RH. Striatin Assembles a Membrane Signaling Complex Necessary for Rapid, Non-genomic Activation of Endothelial NOS by Estrogen Receptor a. Proc. Natl. Acad. Sci. U.S.A. 2004;101(49):17126-31. PubMed Abstract
Tang M, Wang G, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski D,Yan Zhu Y, Mendelsohn, ME. Regulator of G-Protein Signaling 2 Mediates Vascular Smooth Muscle Relaxation and Blood Pressure. Nature Medicine 2003;9(12):1506-1512. PubMed Abstract
Zhu Y, Bian Z, Lu P, Karas RH, Bao L, Cox D, Hodgin J, Shaul PW, Thorén P, Smithies O, Gustafsson J-A, Mendelsohn, ME. Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor Beta. Science 2002;295: 505. Science Abstract. Science Full Text
Yuhanna IS, Zhu, Cox BE, Hahner LD, Osborne-Lawrence S, Lu P, Anderson RGW, Mendelsohn ME, Hobbs HH, Shaul PW. Apoliprotein A-1 binding to scavenger receptor B-1 activates endothelial nitric oxide synthase in caveolae. Nature Medicine, 2001;7:853-857. PubMed Abstract
Poelzel G, Kasai Y, Mochizuki N, Shaul P, Brown M, Mendelsohn ME. Specific association of estrogen receptor with a cell cycle spindle assembly checkpoint protein, MAD2. Proc Natl Acad Sci USA 2000;2836-2839. PubMed Abstract
Karas RH, Hodgins J, Kwoun M, Krege J, Aronovitz M, Mackey W, Gustafsson JA, Korach, Smithies O, Mendelsohn ME. Estrogen inhibits the vascular injury response in estrogen receptor b-deficient mice. Proc Natl Acad Sci USA 1999;96:15133-15136. PubMed Abstract
Surks HK, Mochizuki N, Kasai Y, Ito M, Lincoln TM, Mendelsohn ME. Regulation of myosin phosphatase by a specific interaction with cGMP-dependent protein kinase 1. Science 1999;286: 1583-1587. PubMed Abstract
Mendelsohn ME, Karas RH. Mechanisms of Disease: The protective effects of estrogen on the cardiovascular system. 1999. N Engl J Med 340;1801-1811. PubMed Abstract
Wang G-R, Zhu Y, Lincoln T, Halushka P, Mendelsohn ME. Mechanism of platelet inhibition by nitric oxide. 1998 Proc. Natl. Acad. Sci. U.S.A. 95;4888-4893. PubMed Abstract
Iafrati M, Karas RH, Aronovitz M, Sullivan TR, Jr., Lubahn DB, O’Donnell TF, Jr., Korach KS, Mendelsohn, ME. Estrogen inhibits the vascular injury response in estrogen receptor-deficient mice. Nature Medicine 1997;3:545-548. PubMed Abstract
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