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Molecular Cardiology Research Institute
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 Did you know . . .

 

The MCRI is a world leader in molecular cardiology and cardiovascular research.

 

- MCRI investigators conduct molecular, cellular and translational research on blood vessels and vascular cells.

 

- MCRI investigators conduct molecular, cellular and translational research on the heart and cardiac cells.

 

- MCRI funding comes from the National Institutes of Health, many foundations, and private donations.



MCRI News

 

Fall, 2011

 

Richard H. Karas, MD, PhD, Executive Director of the Molecular Cardiology Research Institute, named Chief Scientific Officer at Tufts Medical Center.

 

 

 

Navin Kapur, MD selected as Finalist, Outstanding Early Career Award, American Heart Association Council on Basic Cardiovascular Sciences 

 

Richard Karas, MD, PhD, named to the National Research Committee of the American Heart Association.

 

Iris Jaffe, MD, PhD, promoted to Associate Professor of Medicine, Tufts University School of Medicine 

 

Tufts Medical Center recently recruited Maria Pilar Alcaide Alonso, PhD, and Jessamyn Bagley, PhD to the faculty as MCRI Investigators.  Dr. Alcaide Alonso studies TH17 cells and inflammation. Dr. Bagley studies the role of micro-RNAs in transplant rejection.

 

The MCRI and Tufts University School of Medicine establish the Translational Immunology Science Center under the leadership of John Iacomini, PhD, Professor of Pathology.  

 

 

Archive

 

 

 

 

 

MCRI Training and Staff Opportunities are available.

Selected MCRI Publications

 

Kapur NK, Heffernan KS, Yunis AA, Nguyen TA, Aronovitz MJ, Parpos P, Wilson S, Baker CK, Esposito ML, Shah A, Kimmelstiel CD, Weintraub A, Karas RH, Mendelsohn ME.  Elevated Soluble fms-Like Tyrosine Kinase-1 Levels in Acute Coronary Occlusion.  Arteriosclerosis Thrombosis, and Vascular Biology 2010; Nov. Pubmed Abstract

 

Jaffe IZ, Newfell BG, Aronovitz M, Mohammad NN, McGraw AP, Perreault RE, Carmeliet P, Ehsan A, Mendelsohn ME.  Placental growth factor mediates aldosterone-dependent vascular injury in mice.  The Journal of Clinical Investigation 2010; 120(11):3891-3900.   PubMed Abstract

 
Beinborn M, Blum A, Hang L, Setiawan T, Schroeder JC, Stoyanoff K, Leung J, Weinstock JV.  TGF-{beta} regulates T-cell neurokinin-1 receptor internalization and function.  Proceedings of the National Academy of Sciences, USA 2010; 107(9):4293-4298.  PubMed Abstract

 

Pang JJ, Gao F, Lem J, Bramblett DE, Paul DL, Wu SM.  Direct rod input to cone BCs and direct cone input to rod BCs challenge the traditional view of mammalian BC circuitry.  Proceedings of the National Academy of Sciences, USA 2009; 107(1):395-400.   PubMed Abstract

 

Mendelsohn ME, Karas RH. Rapid progress for non-nuclear estrogen receptor signaling.  Journal of Clinical Investigation 2010; 120(7):2277-2279.  PubMed

 

Zhang Y, Naggar JC, Welzig CM, Beasley D, Moulton KS, Park HJ, Galper JB.  Simvastatin inhibits angiotensin II-Induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice. Possible role of ERK.  Arteriosclerosis Thrombosis, and Vascular Biology 2009; 29(11):1764-1771.  PubMed

 

Park HJ, Zhang Y, Du C, Welzig CM, Madias C, Aronovitz MJ, Georgescu SP, Naggar I, Wang B, Kim YB, Blaustein RO, Karas RH, Liao R, Mathews CE, Galper JB.  Role of SREBP-1 in the Development of Parasympathetic Dysfunction in the Hearts of Type 1 Diabetic Akita Mice.  Circulation Research 2009; 105(3):278-294.  PubMed Abstract


Fortin JP, Zhu Y, Choi C, Beinborn M, Nitabach MN, Kopin AS.  Membrane-tethered ligands are effective probes for exploring class B1 G protein-coupled receptor function.  Proceedings of the National Academy of Sciences, USA 2009; 106(19):8049-8054   PubMed Abstract


Schultz K, Murthy V, Tatro JB, Beasley D.  Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by HIF-1{alpha}-dependent mechanisms.  American Journal of Physiology - Lung Cellular and Molecular Physiology 2009; 296(6):L921-L927.   PubMed Abstract


Takimoto E, Koitabashi N, Hsu S, Ketner EA, Zhang M, Nagayama T, Bedja D, Gabrielson KL, Blanton R, Siderovski DP, Mendelsohn ME, Kass DA.  Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.  Journal of Clinical Investigation 2009;119(2):408-420.  PubMed Abstract

 

Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS.  Deletion of GSK-3β in Mice Leads to Hypertrophic Cardiomyopathy Secondary to Cardiomyoblast Hyperproliferation.  Journal of Clinical Investigation 2008;118(11):3609-3618.  PubMed Abstract

 

Caprio M, Newfell BG, la Sala A, Baur W, Fabbri A, Rosano G, Mendelsohn ME, Jaffe IZ.  Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion.  Circulation Research 2008;102(11):1359-1367.  PubMed Abstract

 

Michael S, Surks HK, Wang Y, Zhu Y, Blanton R, Jamnongit M, Aronovitz M, Baur W, Ohtani K, Wilkerson MK, Bonev AD, Nelson MT, Karas RH, Mendelsohn ME.  High blood pressure arising from a defect in vascular function.  Proceedings of the National Academy of Sciences, USA 2008;105(18):6702-6707.  PubMed Abstract

 

Park HJ, Georgescu SP, Du C, Madias C, Aronovitz MJ, Welzig CM, Wang B, Begley U, Zhang Y, Blaustein RO, Patten RD, Karas RH, Van Tol HH, Osborne TF, Shimano H, Liao R, Link MS, Galper JB.  Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.  Journal of Clinical Investigation 2008;118(1):259-271.  PubMed Abstract

 

Mendelsohn ME, Karas RH.  HRT and the Young at Heart.  New England Journal of Medicine 2007; 356(25):2639-2641.  PubMed Abstract

 

More Recent Publications