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Molecular Cardiology Research Institute
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 Did you know . . .

 

The MCRI is a world leader in molecular cardiology and cardiovascular research.

 

- MCRI investigators conduct molecular, cellular and translational research on blood vessels and vascular cells.

 

- MCRI investigators conduct molecular, cellular and translational research on the heart and cardiac cells.

 

- MCRI funding comes from the National Institutes of Health, many foundations, and private donations.



MCRI News

 

Fall, 2011

 

Richard H. Karas, MD, PhD, Executive Director of the Molecular Cardiology Research Institute, named Chief Scientific Officer at Tufts Medical Center.

 

 

 

Navin Kapur, MD selected as Finalist, Outstanding Early Career Award, American Heart Association Council on Basic Cardiovascular Sciences 

 

Richard Karas, MD, PhD, named to the National Research Committee of the American Heart Association.

 

Iris Jaffe, MD, PhD, promoted to Associate Professor of Medicine, Tufts University School of Medicine 

 

 

 

Archive

 

 

 

 

 

MCRI Training and Staff Opportunities are available.

Selected Recent Publications

  

Vu DM, Tai A, Tatro JB, Karas RH, Huber BT, Beasley D. γδT cells are prevalent in the proximal aorta and drive nascent atherosclerotic lesion progression and neutrophilia in hypercholesterolemic mice. PLoS One. 2014 Oct 14;9(10):e109416. Pubmed Abstract

 

Barrett Mueller K, Lu Q, Mohammad NN, Luu V, McCurley A, Williams GH, Adler GK, Karas RH, Jaffe IZ. Estrogen Receptor Inhibits Mineralocorticoid Receptor Transcriptional Regulatory Function. Endocrinology. 2014 Jul 22:en20141270. Pubmed Abstract

 

Kapur NK, Qiao X, Paruchuri V, Mackey EE, Daly GH, Ughreja K, Morine KJ, Levine J, Aronovitz MJ, Hill NS, Jaffe IZ, Letarte M, Karas RH. Reducing endoglin activity limits calcineurin and TRPC-6 expression and improves survival in a mouse model of right ventricular pressure overload. J Am Heart Assoc. 2014 Jul 11;3(4). Pubmed Abstract


Sasaki H, Nagayama T, Blanton RM, Seo K, Zhang M, Zhu G, Lee DI, Bedja D, Hsu S, Tsukamoto O, Takashima S, Kitakaze M, Mendelsohn ME, Karas RH, Kass DA, Takimoto E. PDE5 inhibitor efficacy is estrogen dependent in female heart disease. J Clin Invest. 2014 Jun 2;124(6):2464-71. Pubmed Abstract

 

Doyle JR, Krishnaji ST, Zhu G, Xu ZZ, Heller D, Ji RR, Levy BD, Kumar K, Kopin AS. Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain. J Biol Chem. 2014 May 9;289(19):13385-96. doi: 10.1074/jbc.M113.522680. Pubmed Abstract


Zhang Y, Welzig CM, Picard KL, Du C, Wang B, Pan JQ, Kyriakis JM, Aronovitz MJ, Claycomb WC, Blanton RM, Park HJ, Galper JB. Glycogen synthase kinase-3? inhibition ameliorates cardiac parasympathetic dysfunction in type 1 diabetic Akita mice. Diabetes. 2014 Jun;63(6):2097-113. Pubmed Abstract


Gordon FK, Vallaster CS, Westerling T, Iyer LK, Brown M, Schnitzler GR. Research Resource: Aorta- and Liver-Specific ER?-Binding Patterns and Gene Regulation by Estrogen. Mol Endocrinol. 2014 Aug;28(8):1337-51. Pubmed Abstract


Rajab M, Jin H, Welzig CM, Albano A, Aronovitz M, Zhang Y, Park HJ, Link MS, Noujaim SF, Galper JB. Increased inducibility of ventricular tachycardia and decreased heart rate variability in a mouse model for type 1 diabetes: effect of pravastatin. Am J Physiol Heart Circ Physiol. 2013 Dec;305(12):H1807-16. doi: 10.1152/ajpheart.00979.2012. Pubmed Abstract

Pruthi D, McCurley A, Aronovitz M, Galayda C, Karumanchi SA, Jaffe IZ. Aldosterone Promotes Vascular Remodeling by Direct Effects on Smooth Muscle Cell Mineralocorticoid Receptors. Arterioscler Thromb Vasc Biol. 2013 Dec 5. [Epub ahead of print]. Pubmed Abstract

Ueda K, Lu Q, Baur W, Aronovitz MJ, Karas RH. Rapid estrogen receptor signaling mediates estrogen-induced inhibition of vascular smooth muscle cell proliferation. Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1837-43. doi: 10.1161/ATVBAHA.112.300752. Epub 2013 Jun 6. Pubmed Abstract

 

Kapur NK, Paruchuri V, Urbano-Moral JA, Mackey EE, Daly G, Qiao X, Pandian NG, Perides G, Karas RH. Mechanically Unloading the Left Ventricle Before Coronary Reperfusion Reduces Left Ventricular Wall Stress and Myocardial Infarct Size. Circulation. 2013 Jun 13. [Epub ahead of print]. Pubmed Abstract

  

Benelot Moens SJ, Schnitzler GR, Nickerson M, Guo H, Ueda K, Lu Q, Aronovitz M, Nickerson H, Baur W, Hansen U, Iyer LK, Karas RH. Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury. Circulation. 2012; 126:1993-2004. Pubmed Abstract

 

McCurley A, Pires PW, Bender SB, Aronovitz M, Zhao MJ, Metzger D, Chambon P, Hill MA, Dorrance AM, Mendelsohn ME, Jaffe IZ. Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med. 2012 Aug 26. doi: 10.1038/nm.2891. Pubmed Abstract

 

Kapur NK, Wilson S, Yunis AA, Qiao X, Mackey E, Paruchuri V, Baker C, Aronovitz MJ, Karumanchi SA, Letarte M, Kass DA, Mendelsohn ME, Karas RH. Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure. Circulation. 2012 Jun 5;125(22):2728-38. Epub 2012 May 16. Pubmed Abstract

 

Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH. Difference in Th1 and th17 lymphocyte adhesion to endothelium. J Immunol. 2012 Feb;188(3):1421-30. Pubmed Abstract


Albano AJ, Thompson PD, Kapur NK. Acute coronary thrombosis in Boston marathon runners. N Engl J Med. 2012 Jan;366(2):184-5. Pubmed Abstract

 

Higashimori M, Tatro JB, Moore KJ, Mendelsohn ME, Galper JB, Beasley D. Role of toll-like receptor 4 in Intimal foam cell accumulation in apolipoprotein E-deficient mice. Arteriosclerosis Thrombosis, and Vascular Biology 2011 Jan;31(1):50-7. Epub 2010 Oct 21. Pubmed Abstract

 

Jafri H, Alsheikh-Ali AA, Karas RH. Meta-analysis: statin therapy does not alter the association between low levels of high-density lipoprotein cholesterol and increased cardiovascular risk. Ann Intern Med. 2010 Dec 21;153(12):800-8. Pubmed Abstract


Kapur NK, Heffernan KS, Yunis AA, Nguyen TA, Aronovitz MJ, Parpos P, Wilson S, Baker CK, Esposito ML, Shah A, Kimmelstiel CD, Weintraub A, Karas RH, Mendelsohn ME.  Elevated Soluble fms-Like Tyrosine Kinase-1 Levels in Acute Coronary Occlusion.  Arteriosclerosis Thrombosis, and Vascular Biology 2010; Nov. Pubmed Abstract

 

Jaffe IZ, Newfell BG, Aronovitz M, Mohammad NN, McGraw AP, Perreault RE, Carmeliet P, Ehsan A, Mendelsohn ME.  Placental growth factor mediates aldosterone-dependent vascular injury in mice.  The Journal of Clinical Investigation 2010; 120(11):3891-3900.   PubMed Abstract

 
Beinborn M, Blum A, Hang L, Setiawan T, Schroeder JC, Stoyanoff K, Leung J, Weinstock JV.  TGF-{beta} regulates T-cell neurokinin-1 receptor internalization and function.  Proceedings of the National Academy of Sciences, USA 2010; 107(9):4293-4298.  PubMed Abstract

 

Mendelsohn ME, Karas RH. Rapid progress for non-nuclear estrogen receptor signaling.  Journal of Clinical Investigation 2010; 120(7):2277-2279.  PubMed

 

Takimoto E, Koitabashi N, Hsu S, Ketner EA, Zhang M, Nagayama T, Bedja D, Gabrielson KL, Blanton R, Siderovski DP, Mendelsohn ME, Kass DA.  Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.  Journal of Clinical Investigation 2009;119(2):408-420.  PubMed Abstract

 

Park HJ, Georgescu SP, Du C, Madias C, Aronovitz MJ, Welzig CM, Wang B, Begley U, Zhang Y, Blaustein RO, Patten RD, Karas RH, Van Tol HH, Osborne TF, Shimano H, Liao R, Link MS, Galper JB.  Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.  Journal of Clinical Investigation 2008;118(1):259-271.  PubMed Abstract

 

 

More Recent Publications