Tufts Medical Center
Home About Us Contact Us

Molecular Cardiology Research Institute
  text size:  

 Did you know . . .


The MCRI is a world leader in molecular cardiology and cardiovascular research.


- MCRI investigators conduct molecular, cellular and translational research on blood vessels and vascular cells.


- MCRI investigators conduct molecular, cellular and translational research on the heart and cardiac cells.


- MCRI funding comes from the National Institutes of Health, many foundations, and private donations.



Fall, 2011


Richard H. Karas, MD, PhD, Executive Director of the Molecular Cardiology Research Institute, named Chief Scientific Officer at Tufts Medical Center.




Navin Kapur, MD selected as Finalist, Outstanding Early Career Award, American Heart Association Council on Basic Cardiovascular Sciences 


Richard Karas, MD, PhD, named to the National Research Committee of the American Heart Association.


Iris Jaffe, MD, PhD, promoted to Associate Professor of Medicine, Tufts University School of Medicine 


Tufts Medical Center recently recruited Maria Pilar Alcaide Alonso, PhD, and Jessamyn Bagley, PhD to the faculty as MCRI Investigators.  Dr. Alcaide Alonso studies TH17 cells and inflammation. Dr. Bagley studies the role of micro-RNAs in transplant rejection.










MCRI Training and Staff Opportunities are available.

Selected MCRI Publications


Benelot Moens SJ, Schnitzler GR, Nickerson M, Guo H, Ueda K, Lu Q, Aronovitz M, Nickerson H, Baur W, Hansen U, Iyer LK, Karas RH. Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury. Circulation. 2012; 126:1993-2004. Pubmed Abstract


McCurley A, Pires PW, Bender SB, Aronovitz M, Zhao MJ, Metzger D, Chambon P, Hill MA, Dorrance AM, Mendelsohn ME, Jaffe IZ. Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med. 2012 Aug 26. doi: 10.1038/nm.2891. Pubmed Abstract


Kapur NK, Wilson S, Yunis AA, Qiao X, Mackey E, Paruchuri V, Baker C, Aronovitz MJ, Karumanchi SA, Letarte M, Kass DA, Mendelsohn ME, Karas RH. Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure. Circulation. 2012 Jun 5;125(22):2728-38. Epub 2012 May 16. Pubmed Abstract


Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH. Difference in Th1 and th17 lymphocyte adhesion to endothelium. J Immunol. 2012 Feb;188(3):1421-30. Pubmed Abstract

Albano AJ, Thompson PD, Kapur NK. Acute coronary thrombosis in Boston marathon runners. N Engl J Med. 2012 Jan;366(2):184-5. Pubmed Abstract


Shapiro MD , Bagley J, Latz J, Godwin JG, Ge X, Tullius SG, Iacomini J. MicroRNA expression data reveals a signature of kidney damage following ischemia reperfusion injury. PLoS One. 2011 Aug 15; 6(8):e23011. [Epub ahead of print]. Pubmed Abstract


Newfell BG, Iyer LK, Mohammad NN, McGraw AP, Ehsan A, Rosano G, Huang PL, Mendelsohn ME, Jaffe IZ. Aldosterone Regulates Vascular Gene Transcription via Oxidative Stress-Dependent and -Independent Pathways. Arterioscler Thromb Vasc Biol. 2011 Aug; 31(8):1871-80. Pubmed Abstract


Jafri H, Alsheikh-Ali AA, Karas RH. Meta-analysis: statin therapy does not alter the association between low levels of high-density lipoprotein cholesterol and increased cardiovascular risk. Ann Intern Med. 2010 Dec 21;153(12):800-8. Pubmed Abstract

Kapur NK, Heffernan KS, Yunis AA, Nguyen TA, Aronovitz MJ, Parpos P, Wilson S, Baker CK, Esposito ML, Shah A, Kimmelstiel CD, Weintraub A, Karas RH, Mendelsohn ME.  Elevated Soluble fms-Like Tyrosine Kinase-1 Levels in Acute Coronary Occlusion.  Arteriosclerosis Thrombosis, and Vascular Biology 2010; Nov. Pubmed Abstract


Jaffe IZ, Newfell BG, Aronovitz M, Mohammad NN, McGraw AP, Perreault RE, Carmeliet P, Ehsan A, Mendelsohn ME.  Placental growth factor mediates aldosterone-dependent vascular injury in mice.  The Journal of Clinical Investigation 2010; 120(11):3891-3900.   PubMed Abstract

Beinborn M, Blum A, Hang L, Setiawan T, Schroeder JC, Stoyanoff K, Leung J, Weinstock JV.  TGF-{beta} regulates T-cell neurokinin-1 receptor internalization and function.  Proceedings of the National Academy of Sciences, USA 2010; 107(9):4293-4298.  PubMed Abstract


Pang JJ, Gao F, Lem J, Bramblett DE, Paul DL, Wu SM.  Direct rod input to cone BCs and direct cone input to rod BCs challenge the traditional view of mammalian BC circuitry.  Proceedings of the National Academy of Sciences, USA 2009; 107(1):395-400.   PubMed Abstract


Mendelsohn ME, Karas RH. Rapid progress for non-nuclear estrogen receptor signaling.  Journal of Clinical Investigation 2010; 120(7):2277-2279.  PubMed


Takimoto E, Koitabashi N, Hsu S, Ketner EA, Zhang M, Nagayama T, Bedja D, Gabrielson KL, Blanton R, Siderovski DP, Mendelsohn ME, Kass DA.  Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.  Journal of Clinical Investigation 2009;119(2):408-420.  PubMed Abstract


Park HJ, Georgescu SP, Du C, Madias C, Aronovitz MJ, Welzig CM, Wang B, Begley U, Zhang Y, Blaustein RO, Patten RD, Karas RH, Van Tol HH, Osborne TF, Shimano H, Liao R, Link MS, Galper JB.  Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.  Journal of Clinical Investigation 2008;118(1):259-271.  PubMed Abstract



More Recent Publications